Vascular Complications After Transarterial Chemoembolization in Orthotopic Liver Transplant Patients

Shiani, Ashok; Rodriguez, Andrea C.; Lipka, Seth; Sethi, Sajiv; Nehaul, Roger; Chirumamilla, Sirisha; Snyder, Madeline; Strauss, Alexandra T.; Valenzuela, Mauricio; Lai, Andrew; Kumar, Amit; Alsina, Ángel; Kemmer, Nyingi; Brady, Patrick

doi:10.14309/00000434-201510001-02178

Cited by 2 publications

(6 citation statements)

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“…1). [10][11][12][13][14][15][16][17][18][19][20][21][22][23] Combined, these retrospective studies represent a total of 1,122 patients who underwent neo-adjuvant TACE or trans arterial embolization for HCC prior to liver transplantation, and 2,703 patients not bridged with TACE. Seven studies described solely hepatic artery complications, three studies described both hepatic artery and biliary tract complications, and four studies described biliary tract complications only.…”

Section: Literature Search Resultsmentioning

confidence: 99%

“…A meta-analysis of hepatic artery complications comprised data of 10 studies. 11,[13][14][15][16][17][18]20,21,23 Meta-analysis of biliary tract complications comprised data of seven studies. [10][11][12]15,17,19,22 One study with a limited follow up time of 7 days was excluded from the analysis.…”

Section: Literature Search Resultsmentioning

confidence: 99%

“…Five studies provided a clear definition of hepatic artery complications, including thrombosis, stenosis, (pseudo)-aneurysms and anastomotic disruption established by radiological evaluation of the artery. 11,13,16,20,23 Detection of arterial complications by a standardized protocol during long-term clinical follow-up by Doppler ultrasound or CT-angiography was reported in four studies. 13,15,17,20 Four studies defined biliary tract complications clearly, which included anastomotic strictures, non-anastomotic strictures, and/or biliary leaks.…”

Section: Quality Assessmentmentioning

confidence: 99%

“…2). 11,[13][14][15][16][17][18]20,21,23 No evidence of an association between pre-transplant TACE and post-transplant occurrence of hepatic artery thrombosis, alone, was found (OR 1.31, 95% CI: 0.74-2.35; I 2 =0%) (Fig. 3).…”

Section: Hepatic Artery Complicationsmentioning

confidence: 99%

“…The incidence of arterial and/or biliary complications after liver transplantation in patients treated with TACE has been explored in observational studies, however the majority of these studies lack power to detect a clinically significant difference. [10][11][12][13][14][15][16][17][18][19][20][21][22][23] We aimed to investigate the impact of TACE prior to liver transplantation on occurrence of hepatic artery and biliary tract complications after liver transplantation by pooled analyses of published cohorts.…”

Section: Introductionmentioning

confidence: 99%

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Systematic Review and Meta-Analysis of Posttransplant Hepatic Artery and Biliary Complications in Patients Treated With Transarterial Chemoembolization Before Liver Transplantation

et al. 2018

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Section: Literature Search Resultsmentioning

confidence: 99%

Section: Literature Search Resultsmentioning

confidence: 99%

Section: Quality Assessmentmentioning

confidence: 99%

Section: Hepatic Artery Complicationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Systematic Review and Meta-Analysis of Posttransplant Hepatic Artery and Biliary Complications in Patients Treated With Transarterial Chemoembolization Before Liver Transplantation

et al. 2018

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Transarterial chemoembolization of hepatocellular carcinoma before liver transplantation and risk of post-transplant vascular complications: a multicentre observational cohort and propensity score-matched analysis

Sneiders

Boteon

Lerut

et al. 2021

British Journal of Surgery

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Background Transarterial chemoembolization (TACE) in patients with hepatocellular cancer (HCC) on the waiting list for liver transplantation may be associated with an increased risk for hepatic artery complications. The present study aims to assess the risk for, primarily, intraoperative technical hepatic artery problems and, secondarily, postoperative hepatic artery complications encountered in patients who received TACE before liver transplantation. Methods Available data from HCC liver transplantation recipients across six European centres from January 2007 to December 2018 were analysed in a 1 : 1 propensity score-matched cohort (TACE versus no TACE). Incidences of intraoperative hepatic artery interventions and postoperative hepatic artery complications were compared. Results Data on postoperative hepatic artery complications were available in all 876 patients (425 patients with TACE and 451 patients without TACE). Fifty-eight (6.6 per cent) patients experienced postoperative hepatic artery complications. In total 253 patients who had undergone TACE could be matched to controls. In the matched cohort TACE was not associated with a composite of hepatic artery complications (OR 1.73, 95 per cent c.i. 0.82 to 3.63, P = 0.149). Data on intraoperative hepatic artery interventions were available in 825 patients (422 patients with TACE and 403 without TACE). Intraoperative hepatic artery interventions were necessary in 69 (8.4 per cent) patients. In the matched cohort TACE was not associated with an increased incidence of intraoperative hepatic artery interventions (OR 0.94, 95 per cent c.i. 0.49 to 1.83, P = 0.870) Conclusion In otherwise matched patients with HCC intended for liver transplantation, TACE treatment before transplantation was not associated with higher risk of technical vascular issues or hepatic artery complications.

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Vascular Complications After Transarterial Chemoembolization in Orthotopic Liver Transplant Patients

Cited by 2 publications

References 0 publications

Systematic Review and Meta-Analysis of Posttransplant Hepatic Artery and Biliary Complications in Patients Treated With Transarterial Chemoembolization Before Liver Transplantation

Systematic Review and Meta-Analysis of Posttransplant Hepatic Artery and Biliary Complications in Patients Treated With Transarterial Chemoembolization Before Liver Transplantation

Transarterial chemoembolization of hepatocellular carcinoma before liver transplantation and risk of post-transplant vascular complications: a multicentre observational cohort and propensity score-matched analysis

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