Vascular Cognitive Impairment with No Dementia: Neuropsychology, Brain Imaging, and Event-Related Potentials

Abstract

We investigated the neuropsychological characteristics, cranial MRI, and P300 ERPs in patients suffering from vascular cognitive impairment with no dementia (VCIND). A study was performed on 68 cases of VCIND after stroke. The cranial MRI patterns and P300 waves of the patients were compared with those of 56 stroke patients without cognitive impairment and 52 healthy subjects. The MoCA (Montreal Cognitive Assessment) was also used to assess their mental status. The proportion of patients with frontotemporal lesions, multiple lesions, and leukoaraiosis (LA) in the VCIND group was greater than that in the stroke group. The cognitive impairment in patients with the former deficiencies was more significant. The MoCA scores in the VCIND group were significantly lower, and the P300 latency was significantly longer, as compared with other two groups. The P300 latency inversely correlated with the MoCA score. Patients with frontotemporal lesions, multiple lesions, and LA are susceptible to cognitive impairment. The MoCA score and the P300 test are helpful for the early diagnosis of VCIND.

EEG measures for clinical research in major vascular cognitive impairment: recommendations by an expert panel

“…In favor of some specificity of the above oddball ERP components, Podemski et al (2008) showed that mild VCI patients with leukoaraiosis and cortical atrophy had longer N2 and P3b peak latencies in relation to cognitive deficits compared with MCI patients with cortical atrophy only. Similarly, Jiang et al (2014Jiang et al ( , 2013 showed significantly longer auditory P3b peak latency in mild VCI patients in relation to frontotemporal lesions and leukoaraiosis, as compared with age-matched CU persons and patients who had suffered from stroke but without any cognitive impairment. This prolonged P3b latency was even higher for mild VCI patients with hyper-homocysteinemia ( Jiang et al, 2014 ).…”

Hubungan Nilai P300 Dengan Moca-Ina Pada Pasien Dengan Gangguan Kognitif Vaskular Pascastroke Iskemik

“…Gangguan fungsi kognitif pada pasien stroke dapat didiagnosis lebih dini dengan menggabungkan tes neurologis dan tes P300 sehingga dapat memfasilitasi intervensi sewaktu-waktu dan memperbaiki prognosis. 12 Penelitian ini bertujuan untuk mengetahui hubungan nilai P300 dengan gangguan kognitif vaskular pada pasien stroke iskemik.…”