Vascular cognitive impairment and dementia in type 2 diabetes mellitus: An overview

Lyu, Fan; Wu, Dan; Wei, Changwei; Wu, Anshi

doi:10.1016/j.lfs.2020.117771

Cited by 59 publications

(47 citation statements)

References 61 publications

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“…The questionnaire asked "Do you take any treatment (including insulin injections, Western modern medicine and Chinese traditional medicine) to control your diabetes?" Since previous studies have shown that insulin therapy (Plastino et al, 2010;Avgerinos et al, 2018;Lyu et al, 2020), Western modern medicine such as metformin, sulfonylureas and dipeptidyl peptidase-4 inhibitor (Lyu et al, 2020;Samaras et al, 2020) and Chinese traditional medicine (Xu et al, 2013;Seto et al, 2015) were associated with better cognitive function and lower the risk of dementia, we regarded the three kinds of treatment as effective in this study. Participants with diabetes who answered "Yes" were assigned to the treated-diabetes group, whereas those who answered "No" were assigned to the untreated-diabetes group.…”

Section: Definition Of Diabetes Statusmentioning

confidence: 99%

Diabetes Treatment Is Associated With Better Cognitive Function: The Age Disparity

Liu

Zheng

et al. 2022

Front. Aging Neurosci.

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Background: Diabetes mellitus (DM) is a recognised risk factor for cognitive dysfunction. The purpose of this study was to explore the relationship between active treatment for DM and cognitive function in middle-aged (< 60 years) and older adults (≥60 years), respectively.Methods: A total of 13,691 participants (58.55 ± 9.64 years, 47.40% of men) from the Chinese Health and Retirement Longitudinal Study (CHARLS) were included. The participants were classified into three groups according to whether or not they have diabetes and to their diabetes treatment status: diabetes-free, treated-diabetes and untreated-diabetes, in which the diabetes-free group was regarded as reference specially. Cognitive function was assessed by two interview-based measurements for mental intactness and episodic memory.Results: Compared with the participants in the diabetes-free group, the older participants in the treated-diabetes group had better performance in terms of mental intactness (β = 0.37, 95% CI = 0.04–0.70). No significant association was observed in the middle-aged participants. In the subgroup analyses, the lower cognitive score was only observed in people without depression, who had never smoked and drunk, and with a normal weight (body mass index: 18.5–23.9 kg/m2).Conclusion: The cognitive function of actively treated diabetic patients was better than that of patients without diabetes, but the improvement was significant only in elderly people. Depression, smoking, drinking, and an abnormal weight may attenuate this effect.

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Section: Definition Of Diabetes Statusmentioning

confidence: 99%

Diabetes Treatment Is Associated With Better Cognitive Function: The Age Disparity

Liu

Zheng

et al. 2022

Front. Aging Neurosci.

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“…T2DM is the most predominant subtype of diabetes, accounting for approximately 90% of cases (Chen et al, 2011 ; Hu and Jia, 2018 ; Zheng et al, 2018 ). DM and its complications can lead to cognitive impairment (Biessels et al, 2006 ; Cheng et al, 2012 ; McCrimmon et al, 2012 ; Gao et al, 2016 ; Xue et al, 2019 ; Lyu et al, 2020 ). The data show a stronger association between cognitive impairment in T2DM than T1DM (Cheng et al, 2012 ; Gao et al, 2016 ; Lyu et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Altered Structural and Functional MRI Connectivity in Type 2 Diabetes Mellitus Related Cognitive Impairment: A Review

Lei

Luo

et al. 2022

Front. Hum. Neurosci.

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Type 2 diabetes mellitus (T2DM) is associated with cognitive impairment in many domains. There are several pieces of evidence that changes in neuronal neuropathies and metabolism have been observed in T2DM. Structural and functional MRI shows that abnormal connections and synchronization occur in T2DM brain circuits and related networks. Neuroplasticity and energy metabolism appear to be principal effector systems, which may be related to amyloid beta (Aβ) deposition, although there is no unified explanation that includes the complex etiology of T2DM with cognitive impairment. Herein, we assume that cognitive impairment in diabetes may lead to abnormalities in neuroplasticity and energy metabolism in the brain, and those reflected to MRI structural connectivity and functional connectivity, respectively.

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“…As our study had a relatively small sample size, a clearer statistical association may be elucidated with an increased sample size. Several studies had previously shown a signi cant association between DM and dementia [22][23] or cognitive impairment 24 . However, the association of DM and cognitive impairment is not statistically conclusive in our study due to borderline p value.…”

Section: Interpretationsmentioning

confidence: 99%

The value of routine screening for cognitive impairment in a primary care setting: a retrospective cross-sectional study

Qiu¹,

Chang²,

Chang³

2021

Preprint

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BACKGROUND Cognitive impairment is not uncommon among older individuals but is often underdiagnosed in the primary care settings. Our objective is to identify the prevalence of varying degrees of cognitive impairment in older adults in urban primary care clinics. METHODS This cross-sectional study was undertaken from May to July 2019. The Montreal Cognitive Assessment (MoCA) was administered to participants 65-year and older who were seen during a routine visit to our primary care clinic. The participants were recruited on a sequential basis. The primary outcomes of the study were the MoCA scores, and the level of cognitive impairment, if any, indicated by the scores. RESULTS Out of the 133 participants, 46 (34.6%) scored below the cut-off of 23 out of 30, indicating certain level of cognitive impairment. The mean MoCA score was 23.24. The average age was 75.19 years. Average years of education was 12.6. In our cohort, higher MoCA scores were associated with increased years of education. MoCA scores were not inversely correlated with age. Language proficiency in the MoCA test version administered had significant impact on the MoCA scores. CONCLUSIONS A relatively high prevalence of cognitive impairment was found in our cohort. Further study is required to accurately assess the prevalence of cognitive impairment in general population. However, the findings attest the value of routine screening for cognitive impairment in primary care settings and warrant routine screening of older individuals to help in early detection of mild cognitive impairment.

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Vascular cognitive impairment and dementia in type 2 diabetes mellitus: An overview

Cited by 59 publications

References 61 publications

Diabetes Treatment Is Associated With Better Cognitive Function: The Age Disparity

Diabetes Treatment Is Associated With Better Cognitive Function: The Age Disparity

Altered Structural and Functional MRI Connectivity in Type 2 Diabetes Mellitus Related Cognitive Impairment: A Review

The value of routine screening for cognitive impairment in a primary care setting: a retrospective cross-sectional study

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