Vascular changes in the chest wall after unilateral resection of the intercostal nerves in the growing rabbit

Agadir, Mamoun; Sevastik, B.; Reinholt, Finn P.; Perbeck, L.; Sevastik, J.

doi:10.1002/jor.1100080218

Cited by 13 publications

(8 citation statements)

References 16 publications

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“…Support for this was acquired by the fact that a left convex scoliosis developed after intercostal nerve resection on the right side [44,47,48]. According to the authors, this was because of an increase in the vascularity of the structures on the denervated side of the thorax and not to paresis of the trunk muscles [49,50]. Sevastik et al [51][52][53] additionally succeeded to correct such experimentally induced scoliosis either by rib elongation with a metallic expander or further resection of intercostal nerves on the opposite side.…”

Section: Postnatal Procedures Local Interventions Many Investigators Into Experimentalmentioning

confidence: 99%

Experimental animal models in scoliosis research: a review of the literature

et al. 2011

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Although it has been possible to induce scoliosis-like deformities in many animals through various ways, this always required drastic surgical or systemic interventions, thus making the relation to human idiopathic scoliosis unclear. The basic drawback of all used models remains that no animal resembles the upright biomechanical spinal loading condition of man, with its inherent rotational instability of certain spinal segments. The fundamental question remains what the significance of these animal models is to the understanding of human idiopathic scoliosis.

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Section: Postnatal Procedures Local Interventions Many Investigators Into Experimentalmentioning

confidence: 99%

Experimental animal models in scoliosis research: a review of the literature

et al. 2011

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“…Anatomic changes in the thorax after a lung resection may be investigated using computed tomography (CT) [2][3][4] and angiography. 5,6 However, CT cannot be synchronized to the ECG like magnetic resonance imaging (MRI), and angiography is invasive. The purpose of this study was to quantify the changes in the thorax after a lung resection using MRI.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the anatomic changes in the thoracic cage after a lung resection using magnetic resonance imaging

et al. 2000

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The thoracic cage after a lung resection is filled by the remaining lobes, the elevated diaphragm, the diminished thoracic cage, and by mediastinal shifting. The changes in the thorax after a lung resection were quantified using magnetic resonance imaging. The study group consisted of 39 patients who had undergone a lobectomy, four who had undergone a pneumonectomy, and 14 controls. The left ventricular angle, ascending aortic angle, mediastinal shift, longitudinal length of the thoracic cage, the distance between the thoracic apex and the level of the aortic valve, and diaphragmatic elevation were all measured. After a right lower lobectomy, the mediastinum shifted more rightward than after a right upper lobectomy. The diaphragm became more greatly elevated after a right upper lobectomy than after a right lower lobectomy. When a chest wall resection was added to a right upper lobectomy, the mediastinal anatomical changes decreased. After a left upper lobectomy, the degree of mediastinal shifting was greater than after a left lower lobectomy. A left upper lobectomy shifted the mediastinum at the level of the right atrium. This method is easily reproducible and was found to be effective for quantifying the changes in the thorax after a lung resection.

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“…These changes were ascribed to disturbed sympathetic function. Indeed, in growing rabbits stimulation of the longitudinal rib growth by unilateral resection of intercostal nerves, including the sympathetic fibres, resulted in hyperaemia of the denervated anterior hemithorax [1], increased longitudinal rib growth [2] and scoliosis with the convexity to the opposite side of the denervation and characteristics of IS in humans [3].…”

Section: Introductionmentioning

confidence: 99%

A physiological approach to surgical treatment of progressive early idiopathic scoliosis

Xiong

Sevastik

1998

European Spine Journal

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IntroductionThe results of previous studies have shown that in girls with right convex thoracic adolescent idiopathic scoliosis (IS) there is significantly increased vascularity of the left breast as compared with the right one [10]. It has also been found that in deceased women with right convex thoracic IS, the mean length of the ribs corresponding to the apical and the two periapical vertebrae was greater on the concave than on the convex side [11]. These changes were ascribed to disturbed sympathetic function. Indeed, in growing rabbits stimulation of the longitudinal rib growth by unilateral resection of intercostal nerves, including the sympathetic fibres, resulted in hyperaemia of the denervated anterior hemithorax [1], increased longitudinal rib growth [2] and scoliosis with the convexity to the opposite side of the denervation and characteristics of IS in humans [3].The inter-related results of these and other clinical and experimental studies have provided evidence supporting the thoracospinal theory of the pathogenesis of IS. According to this new theory, stimulation of longitudinal growth of the left ribs is the origin of right convex IS in adolescent girls [15].In connection with these studies, experiments were also undertaken to investigate the possibility of correcting or suppressing the progression of scoliosis induced in rabbits.In a first experiment, scoliosis was induced by unilateral resection of three intercostal nerves on the left side in growing rabbits. Three months after the operation, all rabbits had developed scoliosis with a mean Cobb angle of 22.5°. The concavity of the curve was on the side of the denervation. At this time, one rib of the convexity, one, two, three or four spaces above the apical vertebra of the curve, after osteotomy, was mechanically elongated by 7 mm using a metallic expander. The initial scoliosis was corrected immediately after the operation, and remained unchanged 3 weeks later [14] (Fig. 1).In a second experiment, three intercostal nerves were resected on one side of the thorax in rabbits with a mean body weight of 350 g. Then the animals were allocated into three groups, with six rabbits in each. In the first group, used as reference, a progressive scoliosis developed in all animals, which 3 months after the operation averaged 27.0°. In the second group, group A, 1 month af- AbstractThe results of previous clinical and experimental studies have provided accumulated evidence for the role of rib asymmetry in the pathogenesis of idiopathic scoliosis (IS). Moreover, it has been shown that scoliosis induced in rabbits can be corrected by elongation or growth stimulation of ribs on the side of the convexity. Taking these observations into consideration, a 7-year-old girl with right convex thoracolumbar IS was operated upon by 2-cm shortening of three concave ribs. The preoperative coronal Cobb angle was 46°and the sagittal angle was 55°. Twenty-seven months after the operation the curves were reduced to 21°a nd 35°, or by 54 and 36%, respectively. It is concluded ...

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Vascular changes in the chest wall after unilateral resection of the intercostal nerves in the growing rabbit

Cited by 13 publications

References 16 publications

Experimental animal models in scoliosis research: a review of the literature

Experimental animal models in scoliosis research: a review of the literature

Analysis of the anatomic changes in the thoracic cage after a lung resection using magnetic resonance imaging

A physiological approach to surgical treatment of progressive early idiopathic scoliosis

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