Vascular changes in radiation bowel disease

Hasleton, Philip; Carr, N. D.; Schofield, Philip F.

doi:10.1111/j.1365-2559.1985.tb02833.x

Cited by 169 publications

(91 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The resulting decrease in bowel vascularity and ischemia of the rectal wall increase the risk of mucosal ulceration and submucosal fibrosis. 18 Along with focal mucosal ulceration, telangiectatic vessels represent a common source of rectal bleeding. A typical 3-dimensional-rendered plan (lateral view) of a stranded seed implant.…”

Section: Clinical Manifestations Of Chronic Radiation Proctitismentioning

confidence: 99%

Late rectal complications after prostate brachytherapy for localized prostate cancer

Phan¹,

Swanson²,

Levy³

et al. 2009

Cancer

View full text Add to dashboard Cite

This review of the literature on late rectal complications after prostate brachytherapy indicated that it is a highly effective treatment modality for patients with clinically localized prostate cancer but can cause chronic radiation proctitis. The most common manifestation of chronic radiation proctitis was anterior rectal wall bleeding, which often occurred within the first 2 years after brachytherapy. It is interesting to note that the rates of late rectal morbidity appear to have declined over time, which may reflect improvements in implantation techniques and imaging. Rectal biopsy as part of the workup to evaluate rectal bleeding can lead to rectal fistula and the need for colostomy, a rare but major complication. The authors recommend 1) screening colonoscopy before brachytherapy for patients who have not had a screening colonoscopy within the preceding 3 years to rule out colorectal malignancies and, thus, facilitate conservative management should rectal bleeding occur; 2) lifestyle modifications during treatment to limit exposure of the rectum to radiation; and 3) conservative management for rectal bleeding that occurs within 2 years after brachytherapy. Prostate cancer is the leading cause of cancer in men and accounts for approximately 33% of cancer deaths among men in the US.1,2 Management options for organ-confined, low-to intermediate-risk prostate cancer include watchful waiting, radical prostatectomy, external-beam radiation therapy, and prostate brachytherapy with permanent interstitial implants. Recent improvements in radioactive seed implantation techniques have established prostate brachytherapy as a highly effective treatment modality for localized prostate cancer, with long-term local and biochemical control similar to outcomes observed after radical prostatectomy and external-beam radiation therapy. 3,4 Because prostate cancer is diagnosed

show abstract

Section: Clinical Manifestations Of Chronic Radiation Proctitismentioning

confidence: 99%

Late rectal complications after prostate brachytherapy for localized prostate cancer

Phan¹,

Swanson²,

Levy³

et al. 2009

Cancer

View full text Add to dashboard Cite

show abstract

“…Injury of small blood vessels is a prominent feature of the delayed radiation reaction in the intestine and other organs which are rich in stroma (34). Therefore, structural and functional alterations of blood vessels following irradiation have been the focus of considerable interest in experimental research.…”

Section: Vascular Sclerosismentioning

confidence: 99%

Late Radiation Injury of the Small Intestine Clinical, pathophysiologic and radiobiologic aspects: A review

Hauer‐Jensen

1990

Acta Oncologica

View full text Add to dashboard Cite

“…The natural course of radiation enteritis is often characterized by vascular endarteritis and progressive fibrosis of infected intestinal wall (Hasleton et al, 1985). As for CRP, rectal bleeding is the most common symptom and difficult to manage because of recurrence.…”

Section: Discussionmentioning

confidence: 99%

Novel and Effective Almagate Enema for Hemorrhagic Chronic Radiation Proctitis and Risk Factors for Fistula Development

Yuan

Ma²,

Zhong³

et al. 2016

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Radiation proctitis is a common complication after radiotherapy for pelvic malignant tumors. This study was conducted to assess the efficacy of novel almagate enemas in hemorrhagic chronic radiation proctitis (CRP) and evaluate risk factors related to rectal deep ulcer or fistula secondary to CRP. All patients underwent a colonoscopy to confirm the diagnosis of CRP and symptoms were graded. Typical endoscopic and pathological images, risk factors, and quality of life were also recorded. A total of 59 patients were enrolled. Gynecological cancers composed 93.1% of the primary malignancies. Complete or obvious reduction of bleeding was observed in 90% (53/59) patients after almagate enema. The mean score of bleeding improved from 2.17 to 0.83 (P<0.001) after the enemas. The mean response time was 12 days. No adverse effects were found. Moreover, long-term successful rate in controlling bleeding was 69% and the quality of life was dramatically improved (P=0.001). The efficacy was equivalent to rectal sucralfate, but the almagate with its antacid properties acted more rapidly than sucralfate. Furthermore, we firstly found that moderate to severe anemia was the risk factor of CRP patients who developed rectal deep ulcer or fistulas (P= 0.015). We also found abnormal hyaline-like thick wall vessels, which revealed endarteritis obliterans and the fibrosis underlying this disease. These findings indicate that almagate enema is a novel effective, rapid and well-tolerated method for hemorrhagic CRP. Moderate to severe anemia is a risk factor for deep ulceration or fistula.

show abstract

Vascular changes in radiation bowel disease

Cited by 169 publications

References 17 publications

Late rectal complications after prostate brachytherapy for localized prostate cancer

Late rectal complications after prostate brachytherapy for localized prostate cancer

Late Radiation Injury of the Small Intestine Clinical, pathophysiologic and radiobiologic aspects: A review

Novel and Effective Almagate Enema for Hemorrhagic Chronic Radiation Proctitis and Risk Factors for Fistula Development

Contact Info

Product

Resources

About