Vascular change measured with independent component analysis of dynamic susceptibility contrast MRI predicts bevacizumab response in high-grade glioma

LaViolette, Peter S.; Cohen, Alex D.; Prah, Melissa; Rand, Scott D.; Connelly, Jennifer; Malkin, Mark G.; Mueller, Wade; Schmainda, Kathleen M.

doi:10.1093/neuonc/nos323

Cited by 42 publications

(37 citation statements)

References 34 publications

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“…For instance, numerous studies have used dynamic susceptibility-weighted perfusion-weighted imaging, a contrast-enhanced bolus-tracking method, to determine the relative cerebral blood volume within tumors. [9][10][11][12] Arterial spin-labeling (ASL) is an MR imaging-based technique that measures blood flow and has the advantage, compared with DSC-PWI, of not requiring intravenous contrast injection. ASL scans of high quality can be acquired within 4.5 minutes, making it a practical approach to acquire MR perfusion imaging for clinical use.…”

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confidence: 99%

Arterial Spin-Labeling Perfusion MRI Stratifies Progression-Free Survival and Correlates with Epidermal Growth Factor Receptor Status in Glioblastoma

Qiao¹,

Ellingson²,

Kim³

et al. 2014

AJNR Am J Neuroradiol

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confidence: 99%

Arterial Spin-Labeling Perfusion MRI Stratifies Progression-Free Survival and Correlates with Epidermal Growth Factor Receptor Status in Glioblastoma

Qiao¹,

Ellingson²,

Kim³

et al. 2014

AJNR Am J Neuroradiol

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“…16 Targeted inhibitors of VEGF, primarily VEGF receptor (VEGFR1/2), have been developed for several trials involving children with other tumor types. 15,17,25,36 Recently, Gd enhancement has been found to have prognostic significance for some tumors. 33,35 Tumor intravascular enhancement is complex and reflects intratumoral vasodilation, hyperemia, and neovascularity.…”

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confidence: 99%

Differences in vascular endothelial growth factor receptor expression and correlation with the degree of enhancement in medulloblastoma

Hervey-Jumper¹,

Garton²,

Lau³

et al. 2014

PED

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Object Vascular endothelial growth factor (VEGF) is the major proangiogenic factor in many solid tumors. Vascular endothelial growth factor receptor (VEGFR) is expressed in abundance in pediatric patients with medulloblastoma and is associated with tumor metastasis, poor prognosis, and proliferation. Gadolinium enhancement on MRI has been suggested to have prognostic significance for some tumors. The association of VEGF/VEGFR and Gd enhancement in medulloblastoma has never been closely examined. The authors therefore sought to evaluate whether Gd-enhancing medulloblastomas have higher levels of VEGFR and CD31. Outcomes and survival in patients with enhancing and nonenhancing tumors were also compared. Methods A retrospective analysis of patients with enhancing, nonenhancing, and partially enhancing medulloblastomas was performed. Primary end points included risk stratification, extent of resection, and perioperative complications. A cohort of 3 enhancing and 3 nonenhancing tumors was selected for VEGFR and CD31 analysis as well as microvessel density measurements. Results Fifty-eight patients were analyzed, and 20.7% of the medulloblastomas in these patients were nonenhancing. Enhancing medulloblastomas exhibited strong VEGFR1/2 and CD31 expression relative to nonenhancing tumors. There was no significant difference in perioperative complications or patient survival between the 2 groups. Conclusions These results suggest that in patients with medulloblastoma the presence of enhancement on MRI may correlate with increased vascularity and angiogenesis, but does not correlate with worse patient prognosis in the short or long term.

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“…Analysis in the temporal domain may overcome some of the dependency on the analysis process, although it may be more sensitive to scanning parameters. A few studies have performed tumor segmentation in the temporal domain using independent component analysis of DSC MRI to measure perfusion patterns [38], and to predict antiangiogenic therapy response [39] in patients with brain tumors. However, to the best of our knowledge, no previous study has performed tumor segmentation in the temporal domain based on combined vascular imaging methods.…”

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confidence: 99%

Classification of tumor area using combined DCE and DSC MRI in patients with glioblastoma

et al. 2014

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This study proposes an automatic method for identification and quantification of different tissue components: the non-enhanced infiltrative tumor, vasogenic edema and enhanced tumor areas, at the subject level, in patients with glioblastoma (GB) based on dynamic contrast enhancement (DCE) and dynamic susceptibility contrast (DSC) MRI. Nineteen MR data sets, obtained from 12 patients with GB, were included. Seven patients were scanned before and 8 weeks following bevacizumab initiation. Segmentation of the tumor area was performed based on the temporal data of DCE and DSC at the group-level using k-means algorithm, and further at the subject-level using support vector machines algorithm. The obtained components were associated to different tissues types based on their temporal characteristics, calculated perfusion and permeability values and MR-spectroscopy. The method enabled the segmentation of the tumor area into the enhancing permeable component; the non-enhancing hypoperfused component, associated with vasogenic edema; and the non-enhancing hyperperfused component, associated with infiltrative tumor. Good agreement was obtained between the group-level, unsupervised and subject-level, supervised classification results, with significant correlation (r = 0.93, p < 0.001) and average symmetric root-mean-square surface distance of 2.5 ± 5.1 mm. Longitudinal changes in the volumes of the three components were assessed alongside therapy. Tumor area segmentation using DCE and DSC can be used to differentiate between vasogenic edema and infiltrative tumors in patients with GB, which is of major clinical importance in therapy response assessment.

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Vascular change measured with independent component analysis of dynamic susceptibility contrast MRI predicts bevacizumab response in high-grade glioma

Abstract: The independent component analysis dynamic susceptibility contrast-derived biomarker AVOL adds additional information for determining bevacizumab treatment efficacy.

Cited by 42 publications

References 34 publications

Arterial Spin-Labeling Perfusion MRI Stratifies Progression-Free Survival and Correlates with Epidermal Growth Factor Receptor Status in Glioblastoma

Arterial Spin-Labeling Perfusion MRI Stratifies Progression-Free Survival and Correlates with Epidermal Growth Factor Receptor Status in Glioblastoma

Differences in vascular endothelial growth factor receptor expression and correlation with the degree of enhancement in medulloblastoma

Classification of tumor area using combined DCE and DSC MRI in patients with glioblastoma

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