Vascular calcification: Contribution of parathyroid hormone in renal failure

Neves, Kátia R.; Graciolli, Fabiana G.; Reis, Luciene M. dos; Graciolli, Rafael G.; Neves, Camila Zander; Magalhães, Andrea Olivares; Custódio, Melani Ribeiro; Batista, Daniella G.; Jorgetti, Vanda; Moysés, Rosa Maria Affonso

doi:10.1038/sj.ki.5002241

Cited by 172 publications

(121 citation statements)

References 29 publications

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“…16 The causal relationship between hyperparathyroidism and vascular calcification depends, at least in part, on the bone-vascular axis. 17 Therefore, we examined the effects of L-Lys on the femora. Both transverse sections of the femoral diaphyses ( Figure 6A) and threedimensional reconstructed images of the distal femora ( Figure 6B) demonstrated that the rats in group LP had intact femora, whereas the rats in groups Ade and Gly had osteoporotic femora.…”

Section: L-ly Protected the Femora From Osteoporotic Changes In Adenimentioning

confidence: 99%

Dietary L-Lysine Prevents Arterial Calcification in Adenine-Induced Uremic Rats

Shimomura¹,

Matsui²,

Hamano

et al. 2014

Journal of the American Society of Nephrology

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Vascular calcification (VC) is a life-threatening complication of CKD. Severe protein restriction causes a shortage of essential amino acids, and exacerbates VC in rats. Therefore, we investigated the effects of dietary L-lysine, the first-limiting amino acid of cereal grains, on VC. Male Sprague-Dawley rats at age 13 weeks were divided randomly into four groups: low-protein (LP) diet (group LP), LP diet+adenine (group Ade), LP diet+adenine+glycine (group Gly) as a control amino acid group, and LP diet+adenine+L-lysinezHCl (group Lys). At age 18 weeks, group LP had no VC, whereas groups Ade and Gly had comparable levels of severe VC. L-Lysine supplementation almost completely ameliorated VC. Physical parameters and serum creatinine, urea nitrogen, and phosphate did not differ among groups Ade, Gly, and Lys. Notably, serum calcium in group Lys was slightly but significantly higher than in groups Ade and Gly. Dietary L-lysine strongly suppressed plasma intact parathyroid hormone in adenine rats and supported a proper bone-vascular axis. The conserved orientation of the femoral apatite in group Lys also evidenced the bone-protective effects of L-lysine. Dietary L-lysine elevated plasma alanine, proline, arginine, and homoarginine but not lysine. Analyses in vitro demonstrated that alanine and proline inhibit apoptosis of cultured vascular smooth muscle cells, and that arginine and homoarginine attenuate mineral precipitations in a supersaturated calcium/ phosphate solution. In conclusion, dietary supplementation of L-lysine ameliorated VC by modifying key pathways that exacerbate VC.

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Section: L-ly Protected the Femora From Osteoporotic Changes In Adenimentioning

confidence: 99%

Dietary L-Lysine Prevents Arterial Calcification in Adenine-Induced Uremic Rats

Shimomura¹,

Matsui²,

Hamano

et al. 2014

Journal of the American Society of Nephrology

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“…A Mönckeberg-arteriosclerosis esetén pedig a mineralizáció az érfal mediarétegében zajlik. A hosszú időn át fennálló magas szérumfoszfát-koncentráció növeli a kalcifi laxis előfor-dulását, amely a kiserek falának kalcifi kációjával járó, éle-tet veszélyeztető szövődmény [11].…”

Section: A Krónikus Vesebetegség Során Megjelenő áSványi-és Csontanyaunclassified

Az oxidatív stressz hozzájárul a krónikus vesebetegeket érintő vascularis kalcifikáció kialakulásához

Nyitrai

Balla

2015

Orvosi Hetilap

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A rendszeres dialíziskezelésre szoruló vesebetegek körében a halálozási ok leggyakrabban valamilyen cardiovascularis megbetegedés. A cardiovascularis események egyik előidézője a vascularis kalcifi káció, amelynek kialakulási esélye a krónikus vesebetegek körében extrém magas. A kalcifi káció nemcsak az évtizedek óta dialízisterápiában részesülő idősebb korosztályban jelentkezik, hanem a fi atal korosztályt is érinti. Az érrendszerben megjelenő masszív, nagy kiterjedésű kalcifi káció aktív, jól szabályozott komplex folyamat eredményeként alakul ki. Előidézői között szerepel az oxidatív stressz, amely a beteg szervezetében a vese működési zavara következtében nagymértékben fokozódik. A megemelkedett oxidatív terhelést tovább fokozzák a képződő oxidált LDL-formák, amelyek előidézői az endothelialis diszfunkciónak és az érben található simaizomsejtek csontszerű sejtté történő transzdifferenciációjának. Az oxidált hemoglobinból kiszabaduló szabad hem is képes az LDL oxidációjára és ezzel hozzájárul az atherosclerosis kialakulásához. A hemoxigenáz-1/ferritin rendszer indukciója mérsékli a szabad hem ezen káros hatásait. Orv. Hetil., 2015Hetil., , 156(47), 1926Hetil., -1931 Kulcsszavak: vascularis kalcifi káció, krónikus veseelégtelenség, oxidatív stressz, oxidált LDL Oxidative stress: one of the major causes of vascular calcifi cation in chronic kidney disease patientsThe leading cause of high mortality in dialyzed patients is cardiovascular disease. One of the main contributors of cardiovascular event is vascular calcifi cation, which occurs even in very young patients. Multiple factors and complex mechanisms are involved in the formation of robust vascular calcifi cation which affects a large vascular area observed in chronic kidney diseases. Patients on dialysis are exposed to enhanced oxidative stress as a result of increased prooxidant activity and reduced anti-oxidant systems. The oxidation of lipoprotein particles is implicated in the development of vascular damage representing oxidative threat, which leads to endothelial dysfunction. Moreover, in a prooxidant environment osteoblastic trans-differentiation of smooth muscle cells was shown to occur. Heme derived from oxidized hemoglobin might contribute to the formation of reactive lipid metabolites. This oxidative burden contributes to the development of atherosclerosis and vascular calcifi cation. Heme oxygenase-1 and ferritin may serve as intracellular defense mechanisms against such an insult.Keywords: vascular calcifi cation, renal insuffi ciency, oxidative stress, oxidized LDL Nyitrai, M., Balla, Gy., Balla, J. [Oxidative stress: one of the major causes of vascular calcifi cation in chronic kidney disease patients].

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“…In questi ultimi, è stato descritto un ispessimento dell'intima e della media senza la marcata tendenza alla calcificazione tipica della CKD ed è stata, inoltre, registrata la regressione delle alterazioni cardiache dopo la paratiroidectomia. Il PTH, può, pertanto, innescare il processo di calcificazione arteriosa indipendentemente dalla presenza di iperfosforemia (29). Mentre questi risultati hanno evidenziato i risvolti negativi sul deterioramento arterioso secondario all'iperparatiroidismo, altri studi in diversi modelli animali hanno osservato un effetto benefico dello stesso, sulla funzione miocardica, sul tono arterioso, sulla contrattilità cardiaca e sulla vasodilatazione (30)(31)(32).…”

Section: Sodio-potassiounclassified

A Short Glossary for a Better Communication between General Practitioners and Nephrologists

Battistoni

Ricci

Brugnano

et al. 2014

Giornale di Tecniche Nefrologiche e Dialitiche

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Rassegna 19I soggetti con diabete, ipertensione arteriosa, malattie cardiache, obesità, grande anzianità, esposizione a fumo di sigaretta e basso stato sociale hanno maggiori probabilità di essere affetti da IRC. Tali fattori di rischio per la comparsa o la progressione dell'IRC sono in gran parte comuni a quelli per le malattie cardiovascolari. L'IRC è un marcatore di malattia cardiovascolare; alterazioni della funzione renale o dell'esame delle urine possono precedere la comparsa di sintomi di cardiopatia ischemica o l'evidenza strumentale o laboratoristica di una malattia cardiovascolare. Un intervento precoce centrato sui pazienti con IRC aumenta le possibilità di successo della prevenzione e della cura delle malattie cardiovascolari; per tale motivo, la valutazione della funzione renale sta assumendo una crescente importanza, soprattutto in termini di prevenzione secondaria delle complicanze dell'insufficienza renale cronica, potenzialmente letali. Purtroppo risulta, però, scarsa la consapevolezza delle dimensioni del problema e, di conseguenza, dell'importan-L'insufficienza renale cronica (IRC), definita come riduzione del GFR <60 mL/ min/1.73m 2 , è una delle patologie croniche in forte espansione, soprattutto per l'aumento dell'età media della popolazione e dell'incidenza di patologie cardiovascolari e del diabete. la prevalenza della malattia renale cronica è in continuo aumento, anche se di difficile stima, e a ciò concorrono la scarsa sintomaticità e la bassa identificazione negli più precoci. Facendo riferimento alla classificazione della malattia renale proposta dall'American Kidney Foundation e applicabile su scala mondiale (Fig. 1, classificazione K-DOQI), si stima che attualmente, in Italia, circa 3 milioni di pazienti con IRC siano agli stadi 3-5 sec. K-DOQi, ma una percentuale inferiore al 30% di quelli agli stadi 4-5 sarebbe nota presso gli ambulatori nefrologici. Piccolo 1S . C . N e f r o l o g i a e D i a l i s i , A z i e n d a O s p e d a l e P e r u g i a , P e r u g i a 1S . C . N e f r o l o g i a e D i a l i s i , A z i e n d a O s p e d a l e P e r u g i a , P e r u g i a 1S . C . N e f r o l o g i a e D i a l i s i , A z i e n d a O s p e d a l e P e r u g i a , P e r u g i a A short glossAry for A better communicAtion between generAl prActitioners And nephrologistsAbstract. End stage renal disease (ESRD) is a chronic disease with a progressively increasing burden. To date, about 3-million people with ESRD in Italy can be classified with stage 3/5 K-DOQI, but less than 30% of patients with stage 4-5 refer to nephrology outpatient clinics. Despite such evidence, the current knowledge on disease burden and, therefore, on the need to manage and possibly prevent complications is rather limited. General practitioners (GPs) and nephrologists often experience difficulties to communicate and cooperate concerning the appropriate duration of the nephropathic patients' follow-up. As a consequence, delayed diagnoses and increased risk of life-threatening complications are often observed. Indee...

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Vascular calcification: Contribution of parathyroid hormone in renal failure

Cited by 172 publications

References 29 publications

Dietary L-Lysine Prevents Arterial Calcification in Adenine-Induced Uremic Rats

Dietary L-Lysine Prevents Arterial Calcification in Adenine-Induced Uremic Rats

Az oxidatív stressz hozzájárul a krónikus vesebetegeket érintő vascularis kalcifikáció kialakulásához

A Short Glossary for a Better Communication between General Practitioners and Nephrologists

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