Vascular Calcification and Inherited Real Risk of Lithiasis

Inherited Real Risk of Type 2 Diabetes Mellitus: bedside diagnosis, pathophysiology and primary prevention

“…As a matter of fact, pre-hypertension during young adulthood may be involved by coronary calcium later in life exclusively in presence of IRR of CAD, typical for individuals with lithiasic constitution, present in about 50% of all cases of pre-metabolic and metabolic syndrome (Caramel and Stagnaro, 2012). Considering the frequent association between hypertension and diabetes, it is important, to recognize, bed-side, the diabetic predisposition, now-a-days possible from birth, utilizing a lot of clinical methods, some of them above mentioned.…”

“…According to clinical and experimental evidences provided by QBS signs and clinical diagnosis (Stagnaro and Stagnaro-Neri, 1986, 2004; Stagnaro-Neri and Stagnaro, 2004; Caramel and Stagnaro, 2012; Stagnaro and Caramel, 2013) the pathophysiology of T2DM can be resumed in five temporal stages, which play a key role in early diagnosis to avoid complications and glucose metabolism impairment: diabetic and dyslipidemic constitution, IRR of T2DM — overt, latent or potential (individual's birth);abnormal synthesis of perivascular GAGs by fibroblasts, pericytes, mioblasts, megacariocytes, a.s.o. ; Amiline in the Interstitial Fundamental Substance, glycocalix malfunction in both beta-cells and peripheral target-organ cells.…”

“…Since their birth (first stage) all diabetic individuals show QBS signs typical of dyslipidemic “and” diabetic constitutions, and all the related IRR, based on a mitocondrial functional cytopathy termed Congenital Acidosis Enzimo-Metabolic Histangiopathy (CAEMH) (Stagnaro-Neri and Stagnaro, 2004; Caramel and Stagnaro, 2012; Stagnaro and Caramel, 2013), subsequently evolved first into pre-metabolic syndrome (Stagnaro and Singh, 2009) and later on into metabolic one, under the negative influence of well-known environmental factors. In fact, not “all” the individuals, even though obese and/or hypertensive, are at risk of diabetes mellitus, with the same probabilities.…”

“…The objective QBS examination allows physicians to bedside recognize and quantify, in a few minutes, the presence of the IRR of diabetes or overt T2DM, even initial, through the evaluation of several semeiotics signs, i.e., assessing vasomotility and vasomotion impairments, and the typical pathological EBDs (Ditzel, 1968; Stagnaro and Stagnaro-Neri, 1986, 2004; Stagnaro-Neri and Stagnaro, 2004; Caramel and Stagnaro, 2012; Stagnaro and Caramel, 2013). The IRR of T2DM is characterized by a microcirculatory remodeling due to the functional and structural abnormalities just mentioned.…”

BRCA-1 and BRCA-2 mutation bedside detection and breast cancer clinical primary prevention

“…This is the basis for one or more QBS constitutions (Stagnaro and Stagnaro-Neri, 2004b), in our case, Oncological Terrain (Stagnaro, 2004), which could bring about their respective IRR, i.e., IRR of cancer (Stagnaro, 2009; Stagnaro and Caramel, 2012, 2013a,b). The QBS method allows the clinical and pre-clinical diagnosis of the most severe diseases such as the IRR of breast cancer (Stagnaro, 2004, 2005a,b,c,d), which is achieved in the easier way through the auscultatory percussion of the stomach (Stagnaro, 1985, 2005e).…”