Vascular calcification and cellular signaling pathways as potential therapeutic targets

Kang, Jeong-Hun; Kawano, Takahito; Murata, Masaharu; Toita, Riki

doi:10.1016/j.lfs.2023.122309

Life Sciences

2024

DOI: 10.1016/j.lfs.2023.122309

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Vascular calcification and cellular signaling pathways as potential therapeutic targets

Jeong-Hun Kang,

Takahito Kawano,

Masaharu Murata

et al.

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2024

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Cited by 2 publications

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The emerging roles of irisin in vascular calcification

Wang,

Hu,

Pan

2024

Front. Endocrinol.

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Vascular calcification is a common accompanying pathological change in many chronic diseases, which is caused by calcium deposition in the blood vessel wall and leads to abnormal blood vessel function. With the progress of medical technology, the diagnosis rate of vascular calcification has explosively increased. However, due to its mechanism’s complexity, no effective drug can relieve or even reverse vascular calcification. Irisin is a myogenic cytokine regulating adipose tissue browning, energy metabolism, glucose metabolism, and other physiological processes. Previous studies have shown that irisin could serve as a predictor for vascular calcification, and protect against hypertension, diabetes, chronic kidney disease, and other risk factors for vascular calcification. In terms of mechanism, it improves vascular endothelial dysfunction and phenotypic transformation of vascular smooth muscle cells. All the above evidence suggests that irisin plays a predictive and protective role in vascular calcification. In this review, we summarize the association of irisin to the related risk factors for vascular calcification and mainly explore the role of irisin in vascular calcification.

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The emerging roles of irisin in vascular calcification

Wang,

Hu,

Pan

2024

Front. Endocrinol.

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Vascular Calcification: Molecular Networking, Pathological Implications and Translational Opportunities

Ortega,

De Leon-Oliva,

Gimeno-Longas

et al. 2024

Biomolecules

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Calcification is a process of accumulation of calcium in tissues and deposition of calcium salts by the crystallization of PO43− and ionized calcium (Ca2+). It is a crucial process in the development of bones and teeth. However, pathological calcification can occur in almost any soft tissue of the organism. The better studied is vascular calcification, where calcium salts can accumulate in the intima or medial layer or in aortic valves, and it is associated with higher mortality and cardiovascular events, including myocardial infarction, stroke, aortic and peripheral artery disease (PAD), and diabetes or chronic kidney disease (CKD), among others. The process involves an intricate interplay of different cellular components, endothelial cells (ECs), vascular smooth muscle cells (VSMCs), fibroblasts, and pericytes, concurrent with the activation of several signaling pathways, calcium, Wnt, BMP/Smad, and Notch, and the regulation by different molecular mediators, growth factors (GFs), osteogenic factors and matrix vesicles (MVs). In the present review, we aim to explore the cellular players, molecular pathways, biomarkers, and clinical treatment strategies associated with vascular calcification to provide a current and comprehensive overview of the topic.

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Vascular calcification and cellular signaling pathways as potential therapeutic targets

Cited by 2 publications

References 248 publications

The emerging roles of irisin in vascular calcification

The emerging roles of irisin in vascular calcification

Vascular Calcification: Molecular Networking, Pathological Implications and Translational Opportunities

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