Vascular calcification and cardiac function according to residual renal function in patients on hemodialysis with urination

Shin, Dong Ho; Lee, Young-Ki; Oh, Jieun; Yoon, Jong‐Woo; Rhee, So Yon; Kim, Eun-Jung; Ryu, Jiwon; Cho, Ajin; Jeon, Hee Jung; Choi, Moon-Gi; Noh, Jung‐Woo

doi:10.1371/journal.pone.0185296

Cited by 9 publications

(9 citation statements)

References 40 publications

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“…Although there is a relationship between IDWG and BP increase in the LII, this relationship is not linear 34 . Thus, we did not find a difference between the two groups regarding mean BP, proportion of patients with adequate BP levels at the end of the interval, and amount of antihypertensive drugs used, findings similar to those reported in the literature 12,30,32 .…”

Section: Discussionsupporting

confidence: 90%

“…The results in the literature are controversial in this regard. Indeed, Shin et al 32 , when comparing patients with urea clearance higher and lower than 0.9 mL/min in three Korean HD units, also found no difference between the groups for serum calcium levels (8.7 x 8.6 mg/dL, p = 0.92). On the other hand, Wang et al 30 performed a single-center study with 134 Chinese patients who found lower calcium values in the RRF group (9.1 x 9.8 mg/dL; p < 0.001).…”

Section: Discussionmentioning

confidence: 95%

“…On the other hand, Wang et al 30 performed a single-center study with 134 Chinese patients who found lower calcium values in the RRF group (9.1 x 9.8 mg/dL; p < 0.001). The great variation of calcemia in dialysis patients, influenced by factors other than renal excretion, could explain these different results 32 .…”

Section: Discussionmentioning

confidence: 99%

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Metabolic and volume status evaluation of hemodialysis patients with and without residual renal function in the long interdialytic interval

et al. 2019

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Introduction: It is unclear whether residual renal function (RRF) in dialysis patients can attenuate the metabolic impact of the long 68-hour interdialytic interval, in which water, acid, and electrolyte accumulation occurs. Objective: to evaluate serum electrolyte levels, water balance, and acid-base status in dialytic patients with and without RRF over the long interdialytic interval (LII). Methodology: this was a single-center, cross-sectional, and analytical study that compared patients with and without RRF, defined by diuresis above 200 mL in 24 hours. Patients were weighed and serum samples were collected for biochemical and gasometric analysis at the beginning and at the end of the LII. Results: 27 and 24 patients with and without RRF were evaluated, respectively. Patients without RRF had a higher increase in serum potassium during the LII (2.67 x 1.14 mEq/L, p < 0.001), reaching higher values at the end of the study (6.8 x 5.72 mEq/L, p < 0.001) and lower pH value at the beginning of the interval (7.40 x 7.43, p = 0.018). More patients with serum bicarbonate < 18 mEq/L (50 x 14.8%, p = 0.007) and mixed acid-base disorder (57.7 x 29.2%, p = 0.042), as well as greater interdialytic weight gain (14.67 x 8.87 mL/kg/h, p < 0.001) and lower natremia (137 x 139 mEq/L, p = 0.02) at the end of the interval. Calcemia and phosphatemia were not different between the groups. Conclusion: Patients with RRF had better control of serum potassium, sodium, acid-base status, and volemia throughout the LII.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 95%

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Metabolic and volume status evaluation of hemodialysis patients with and without residual renal function in the long interdialytic interval

et al. 2019

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“…For this prospective observational study, we enrolled patients undergoing haemodialysis at three dialysis clinics (Kangdong Sacred Heart Hospital, Kangnam Sacred Heart Hospital, and Chuncheon Sacred Heart Hospital) between January 2014 and February 2015. Of note, based on these patients' clinical data, we previously showed the associations between vascular calcification and various clinical characteristics 28,29 . All patients regularly underwent vascular access monitoring and surveillance according to the KDOQI guidelines.…”

Section: Discussionmentioning

confidence: 75%

Static intra-access pressure ratio and cardiovascular events in patients undergoing haemodialysis

Jeon

Lee

et al. 2020

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Static intra-access pressure ratio (SiApR) measurement, using haemodialysis machine transducers, is the vascular access surveillance method in patients undergoing haemodialysis. However, little is known about the relationship between the SIAPR and arterial stiffness, and the clinical usefulness of the SIAPR in predicting cardiovascular events. A total of 209 patients undergoing maintenance haemodialysis were evaluated. The SIAPRs ranged from 0.01 to 0.52 (median: 0.23). When the patients were divided into two groups according to their median of SIAPR, the incidence of previous cardiovascular disease, e/e′ ratio, and brachial-ankle pulse wave velocity were significantly higher in the patients with SIAPRs of ≤0.23 than in those with SIAPRs of >0.23. Conversely, patients with worse comorbid status had a lower SIAPR than patients without it. In the Kaplan-Meier analysis, the cumulative incidence of cardiovascular events was significantly higher in the patients with SIAPRs of ≤0.23 than in those with SIAPRs of >0.23 (P < 0.001). In the multiple Cox regression analysis, an increase in the SIAPR was associated with a reduced risk for cardiovascular events [hazard ratio: 0.36, 95% confidence interval: 0.21-0.60, P = 0.001]. Therefore, a low SIAPR related with arterial stiffness was a predictor for cardiovascular events.

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“…34 One study reports a progressive increase of arterial stiffness as a predictor of mortality and cardiovascular events among patients with end-stage kidney failure, regardless of anemia, nutrition levels and hemoglobin variability. 35 Patients with CKD may experience arterial stiffness due to decreased arterial compliance and glomerular filtration. 34 When comparing clinical variables with arterial stiffness, systolic blood pressure (SBP) was found to be statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Efeitos da doença e adequação da hemodiálise em pacientes com rigidez arterial

et al. 2020

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Objectives:To analyze the adequacy of hemodialysis treatment in patients with arterial stiffness and to associate the effects of renal disease with sociodemographic and clinical factors. Method: A cross-sectional epidemiological study with 149 chronic renal patients undergoing hemodialysis treatment, in the interior of the State of São Paulo. They used to measure arterial stiffness with the Dyna-MAPA  device. The tests statistical were multivariate linear regression, t Student and chi-square were applied to the biomarkers and the occurrence of arterial stiffness. Results: Most were of productive age, professionally inactive, male, in a stable union, water, and food restriction, and with less than 48 months of dialysis treatment and 36.9% of patients had arterial stiffness. The biomarkers creatinine, urea, and phosphorus were increased, hematocrit and hemoglobin were decreased, mean interdialytic weight was 2.34 ± 1.4kg, and most of the Kt / V inadequate. The effects of renal disease were statistically significant with those enrolled in the transplant list, longer treatment time, and increased creatinine. Conclusion: These results are expected to reduce cardiovascular morbidity and mortality in these patients. RESUMOObjetivos: Analisar a adequação do tratamento hemodialítico em pacientes com rigidez arterial e associar os efeitos da doença renal com os fatores sociodemográficos e clínicos. Método: Estudo epidemiológico, transversal realizado com 149 renais crônicos em tratamento de hemodiálise, no interior do Estado de São Paulo. Utilizou para medida da rigidez arterial o aparelho de Dyna-MAPA  . Foram aplicados os testes de regressão linear multivariada, t Student e o qui-quadrado para os biomarcadores e a ocorrência de rigidez arterial. Resultados: A maioria estava em idade produtiva, inativa profissionalmente, do sexo masculino, em união estável, fazendo restrição hídrica e alimentar e com menos de 48 meses de tratamento dialítico e 36,9% dos pacientes apresentavam rigidez arterial. Os biomarcadores creatinina, ureia e fósforo estavam aumentados, hematócrito e hemoglobina estavam diminuídos, média de peso interdialítico de 2,34 ± 1,4 kg, e a maioria do Kt/V inadequado. Quanto aos efeitos da doença renal observou-se significância estatística com os inscritos na lista de transplantes, maior tempo de tratamento e aumento da creatinina. Conclusão: Espera-se que esses resultados proporcionem a diminuição da morbimortalidade cardiovascular desses pacientes. Palavras-chave: Doença renal crônica; Qualidade de vida; Hemodiálise; Rigidez arterial; Velocidade de onda de pulso. RESUMENObjetivos: Analizar la adecuación del tratamiento hemodialítico en pacientes con rigidez arterial y asociar los efectos de la enfermedad renal con los factores sociodemográficos y clínicos. Método: Estudio epidemiológico, transversal realizado con 149 renales crónicos en tratamiento de hemodiálisis, en el interior del Estado de São Paulo. Utilizaron el instrumento para medir la rigidez arterial el aparato de Dyna-MAPA  . Se aplicaron los p...

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Vascular calcification and cardiac function according to residual renal function in patients on hemodialysis with urination

Cited by 9 publications

References 40 publications

Metabolic and volume status evaluation of hemodialysis patients with and without residual renal function in the long interdialytic interval

Metabolic and volume status evaluation of hemodialysis patients with and without residual renal function in the long interdialytic interval

Static intra-access pressure ratio and cardiovascular events in patients undergoing haemodialysis

Efeitos da doença e adequação da hemodiálise em pacientes com rigidez arterial

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