Vascular Biology of Arterial Aneurysms

Costa, Davide; Andreucci, Michele; Ielapi, Nicola; Serraino, Giuseppe Filiberto; Mastroroberto, Pasquale; Bracale, Umberto Marcello; Serra, Raffaele

doi:10.1016/j.avsg.2023.04.008

Cited by 4 publications

(2 citation statements)

References 95 publications

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“…This observation may be linked to the formation of the aortic intima or signify the migration of cells from the intima to the media. In human aorta, intimal cells appear during the early prenatal period, but their nature and origin remain unexplored and are directly connected to medial SMCs through the internal elastic membrane [ 39 ] . SMCs may emerge in the intima because of cell migration from the media.…”

Section: Intimal Structure and Thickeningmentioning

confidence: 99%

Atherosclerosis originating from childhood: Specific features

Poznyak,

Yakovlev,

Popov

et al. 2024

J Biomed Res

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Atherosclerosis is extremely widespread. Traditionally, it is considered a disease of older people, who most often experience problems with the heart and blood vessels. While much attention from the scientific community has been paid to studying the association between aging and atherosclerosis, as well as its consequences, there is evidence that atherosclerosis occurs at an early age. Atherosclerosis may form both during intrauterine development and in childhood. Nutrition plays an important role in childhood atherosclerosis, along with previous infectious diseases and excess weight of both the child and the mother. In the present review, we examined the development of atherosclerosis and the prerequisites in childhood.

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Section: Intimal Structure and Thickeningmentioning

confidence: 99%

Atherosclerosis originating from childhood: Specific features

Poznyak,

Yakovlev,

Popov

et al. 2024

J Biomed Res

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show abstract

“…There are three main families of metalloproteinases (MPs) that are involved in human health and disease: (1) the "matrix metalloproteinase" (MMP) family, (2) the "a disintegrin and metalloprotease" (ADAM) family, and (3) the "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family. All these families belong to the superfamily of zinc endopeptidases, which are called metzincins [1][2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Metalloproteinases between History, Health, Disease, and the Complex Dimension of Social Determinants of Health

Costa

Ielapi

Minici

et al. 2023

JVD

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Metalloproteinases (MPs) belong to the superfamily of zinc endopeptidases, which are called metzincins. Three families of MPs have been studied in healthy and diseased conditions in humans. The first study on MPs was published in 1962, and following that, several studies characterized their activity and their effect on health and disease. Several diseases have been related to MPs, such as cardiovascular disease, cancer, inflammatory diseases, gynecological disorders, and others. Moreover, tissue inhibitors of metalloproteinases (TIMPs) have been widely studied, and drugs and artificial molecules that could target MP activity have been evaluated. MPs are relevant to public health because of their role in several diseases and, most of all, their role as biomarkers that also impact the quality of life and the psychosocial dimension of affected patients. In this context, new pathways to precision health and precision medicine have been opened in the area of MPs. This review describes, from the initial studies, the complex dimensions of MPs and related issues centered on health and disease dimensions.

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Molecular Insight into Acute Limb Ischemia

Costa,

Ielapi,

Perri

et al. 2024

Biomolecules

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Acute limb ischemia (ALI) is defined as a sudden reduction in blood flow to a limb, resulting in cessation of blood flow and, therefore, cessation of the delivery of nutrients and oxygen to the tissues of the lower limb. Despite optimal treatment to restore blood flow to ischemic tissues, some patients may suffer from ischemia/reperfusion (I/R) syndrome, the most severe complication after a revascularization procedure used to restore blood flow. There are multiple molecular and cellular factors that are involved in each phase of ALI. This review focuses firstly on molecular and cellular factors of arterial thrombosis, highlighting the role of atherosclerotic plaques, smooth muscle cells (SMCs), and cytokine which may alter key components of the extracellular matrix (ECM). Then, molecular and cellular factors of arterial embolism will be discussed, highlighting the importance of thrombi composition. Molecular and cellular factors of ischemia/reperfusion syndrome are analyzed in depth, highlighting several important mechanisms related to tissue damage, such as inflammation, apoptosis, autophagy, necrosis, and necroptosis. Furthermore, local and general complications of ALI are discussed in the context of molecular alterations. Ultimately, the role of novel biomarkers and targeted therapies is discussed.

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Vascular Biology of Arterial Aneurysms

Cited by 4 publications

References 95 publications

Atherosclerosis originating from childhood: Specific features

Atherosclerosis originating from childhood: Specific features

Metalloproteinases between History, Health, Disease, and the Complex Dimension of Social Determinants of Health

Molecular Insight into Acute Limb Ischemia

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