Vascular Anomalies (Part II): Interventional Therapy of Peripheral Vascular Malformations

Müller-Wille, René; Wildgruber, Moritz; Sadick, Maliha; Wohlgemuth, Walter A.

doi:10.1055/s-0044-101266

Cited by 63 publications

(61 citation statements)

References 67 publications

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“…2 Whereas vascular tumors may regress as the patient ages, vascular malformations increase in size and never regress on their own. 2,3 Accurate diagnosis is crucial for appropriate evaluation and management, often requiring multidisciplinary specialists. Classification schemes provide a consistent terminology and serve as a guide for pathologists, clinicians, and researchers.…”

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confidence: 99%

Efficacy and safety of sirolimus in the treatment of vascular anomalies: A systematic review

Freixo

Ferreira

Martins

et al. 2020

Journal of Vascular Surgery

129

108

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Objective: The management of vascular anomalies is complex and requires a multidisciplinary team with a combination of medical, surgical, and intervention treatments. Medical treatment is limited and has conflicting results. Off-label use of mammalian target of rapamycin inhibitors shows promising results. The objective of this study was to systematically evaluate the literature published about the efficacy and safety of sirolimus in the treatment of vascular anomalies. Methods: A systematic review of the published literature was conducted using the PubMed database and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: There were 73 articles included: 2 randomized controlled studies, 2 nonrandomized prospective studies, and 69 retrospective case reports and case series. In total, 373 patients were included. Sirolimus was administered topically to 56 patients and orally to 317 patients. Sirolimus was highly effective in the treatment of vascular tumors associated with Kasabach-Merritt phenomenon (95.5% of the patients clinically improved and 93% had normalization of coagulopathy), venous malformations (size reduction was observed in 88.9% of patients), and lymphatic malformations (clinical improvement in 94.9% of patients). Topical sirolimus results were conflicting. Arteriovenous malformations were not improved by sirolimus. Conclusions: Low-level evidence suggests that sirolimus can improve the prognosis of vascular anomalies, most notably vascular tumors associated with life-threatening coagulopathy and venous and lymphatic malformations. Further research is needed to establish the benefits of sirolimus in the management of vascular anomalies.

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confidence: 99%

Efficacy and safety of sirolimus in the treatment of vascular anomalies: A systematic review

Freixo

Ferreira

Martins

et al. 2020

Journal of Vascular Surgery

129

108

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“…"plug-and-push"-Technik ermöglicht komplexe Embolisationen bei angeborenen arteriovenösen Malformationen (▶ Abb. 25) [47].…”

Section: Merkeunclassified

Gefäßverschließende Methoden (Embolotherapie)

Müller-Wille¹

2018

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“…The differences among VAs have been widely debated and revisited over the years. Recently, VAs have been reanalyzed by the International Society for the Study of Vascular Anomalies (ISSVA), which classified them in vascular tumors (benign, locally aggressive or borderline, and malignant) and VMs [3][4]. The latter are subclassified as follows: (a) simple; (b) combined, when two or more vascular malformation types are found in a single lesion; (c) anomalies of major vessels, also known as "channel type" or "truncal" VMs; anomalies of (d) origin, (e) course, (f) number, (g) length, (h) diameter; the last group also includes syndromic VMs associated with other anomalies.…”

Section: Introductionmentioning

confidence: 99%

Diode Laser Photocoagulation of Oral Venous Malformations in Patients on Anticoagulant Therapy Without Drug Discontinuation

Dell’Olio

Falco

Nanna

et al. 2020

Cureus

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Vascular Anomalies (Part II): Interventional Therapy of Peripheral Vascular Malformations

Abstract: · Müller-Wille R, Wildgruber M, Sadick M et al. Vascular Anomalies (Part II): Interventional Therapy of Peripheral Vascular Malformations. Fortschr Röntgenstr 2018; DOI: 10.1055/s-0044-101266.

Cited by 63 publications

References 67 publications

Efficacy and safety of sirolimus in the treatment of vascular anomalies: A systematic review

Efficacy and safety of sirolimus in the treatment of vascular anomalies: A systematic review

Gefäßverschließende Methoden (Embolotherapie)

Diode Laser Photocoagulation of Oral Venous Malformations in Patients on Anticoagulant Therapy Without Drug Discontinuation

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