Vascular and platelet responses to aspirin in patients with coronary artery disease

Blann, Andrew D.; Kuzniatsova, N; Lip, Gregory Y.H.

doi:10.1111/eci.12021

Cited by 15 publications

(18 citation statements)

References 54 publications

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“…Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval; PCSK9, proprotein convertase subtilisin/kexin type 9; PLT, platelet; PCT, plateletcrit; PDW, platelet distribution width; MPV, mean platelet volume; BMI, body mess index; CAD, coronary artery disease. tially important clinical issue in the present study 23) . In addition, the sample would have been very small if the factor of aspirin/anti-platelet administration had been considered.…”

Section: Discussionmentioning

confidence: 68%

The Relationship between the Plasma PCSK9 Levels and Platelet Indices in Patients with Stable Coronary Artery Disease

Zhu

Guo

et al. 2015

J Atheroscler Thromb

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Aim: Recent studies have shown that platelet indices are linked to metabolic and cardiovascular diseases, in addition to being markers of hemostasis. These studies suggested that they could be modified by various biomolecules, including lipids. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a newly-identified member, plays a key role in lipid metabolism and atherosclerosis. Therefore, we evaluated the relationship between the plasma PCSK9 level and platelet indices.

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Section: Discussionmentioning

confidence: 68%

The Relationship between the Plasma PCSK9 Levels and Platelet Indices in Patients with Stable Coronary Artery Disease

Zhu

Guo

et al. 2015

J Atheroscler Thromb

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“…Some data in favor of the former notion was provided in the above-mentioned study by Yong et al [33], in which EMMPRIN expression in circulating platelets obtained from the coronary sinus of stable CAD patients was significantly higher than in those obtained from their peripheral vein, the difference was not significant for soluble EMMPRIN levels in the plasma. There are also data in favor of the latter notion: it has been shown that aspirin reduced the platelet expression of P-selectin and PAC-1 [36] and clopidogrel reduced the platelet expression of PAC-1 and circulating levels of soluble P-selectin [37], and that both of these proteins were positively and highly correlated with platelet EMMPRIN expression [10]. Similarly, fluvastatin, has been shown to reduce EMMPRIN expression in macrophages [32].…”

Section: Discussionmentioning

confidence: 99%

Plasma EMMPRIN levels in acute myocardial infarction and stable coronary artery disease

Akkuş¹,

Ormam²,

Seyis³

et al. 2016

CIM

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Plasma EMMPRIN levels in acute myocardial infarction and stable coronary artery disease Abstract Purpose: The purpose of this study was to determine whether the plasma levels of soluble extracellular matrix metalloproteinase inducer (EMMPRIN) differed among the patients with ST-elevation myocardial infarction (STEMI), non-STEMI (NSTEMI) and stable coronary artery disease (CAD) and the healthy controls, and to identify the factors associated with the differences in plasma levels of this this protein among patients in these groups.Methods: Plasma EMMPRIN levels were compared among four age-and sex-matched groups of patients with STEMI, NSTEMI and stable CAD and healthy controls (n=44 per group), then logistic regression and correlation analyses were conducted for the whole acute myocardial infarction (AMI) patients group.Results: EMMPRIN levels were significantly higher in the STEMI (39.4±9.2ng/mL) and NSTEMI (37.1±10.5ng/mL) groups than in either the stable CAD (27.5±4.7ng/mL) or control (24.5±5.8ng/mL) groups (p<0.001 for each comparison), whereas the differences between the STEMI and NSTEMI groups, and between the stable CAD group and the controls, was not significant. Moreover, in the whole AMI patients group, the elevation of EMMPRIN was independent of the other variables (Odds ratio=1.25, 95% confidence intervals=1.16-1.34, p<0.001), and EMMPRIN levels were correlated significantly and positively with the plasma levels of peak creatine kinase-MB (r=0.22, p<0.05), peak cardiac troponin T (r=0.27, p<0.05) and admission C-reactive protein (r=0.26, p<0.05), and correlated significantly and inversely with left ventricular ejection fraction (r=-0.22, p< 0.05).Conclusion: EMMPRIN seems to play a role in the pathogenesis of AMI and its measurement in the plasma may play a role in the diagnosis of this disease.ORIGINAL RESEARCH

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“…Moreover, HPR detected by PFA-100 does not correlate with the results of LTA-AA: none of the 116 patients with a definition of HPR at T 0 exhibited a LTA-AA >20%, the cut-off value accepted to describe a condition of aspirin resistance [19]. …”

Section: Discussionmentioning

confidence: 99%

Von Willebrand Factor Antigen Predicts Response to Double Dose of Aspirin and Clopidogrel by PFA‐100 in Patients Undergoing Primary Angioplasty for St Elevation Myocardial Infarction

Gianetti

Parri

Pina

et al. 2013

The Scientific World Journal

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Von Willebrand factor (VWF) is an emerging risk factor in acute coronary syndromes. Platelet Function Analyzer (PFA-100) with Collagen/Epinephrine (CEPI) is sensitive to functional alterations of VWF and also identifies patients with high on-treatment platelet reactivity (HPR). The objective of this study was to verify the effect of double dose (DD) of aspirin and clopidogrel on HPR detected by PFA-100 and its relation to VWF and to its regulatory metalloprotease ADAMTS-13. Between 2009 and 2011 we enrolled 116 consecutive patients with ST elevation myocardial infarction undergoing primary PCI with HPR at day 5 after PCI. Patients recruited were then randomized between a standard dose (SD, n = 58) or DD of aspirin and clopidogrel (DD, n = 58), maintained for 6 months follow-up. Blood samples for PFA-100, light transmittance aggregometry, and VWF/ADAMTS-13 analysis were collected after 5, 30, and 180 days (Times 0, 1, and 2). At Times 1 and 2 we observed a significantly higher CEPI closure times (CT) in DD as compared to SD (P < 0.001). Delta of CEPI-CT (T1 − T0) was significantly related to VWF (P < 0.001) and inversely related to ADAMTS-13 (0.01). Responders had a significantly higher level of VWF at T0. Finally, in a multivariate model analysis, VWF and ADAMTS-13 in resulted significant predictors of CEPI-CT response (P = 0.02). HRP detected by PFA-100 in acute myocardial infarction is reversible by DD of aspirin and clopidogrel; the response is predicted by basal levels of VWF and ADAMTS-13. PFA-100 may be a useful tool to risk stratification in acute coronary syndromes given its sensitivity to VWF.

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Vascular and platelet responses to aspirin in patients with coronary artery disease

Abstract: We conclude that LTA is a more sensitive marker of aspirin resistance than is flow cytometry for P-selectin and PCA-1, and that aspirin response has no influence on vascular function.

Cited by 15 publications

References 54 publications

The Relationship between the Plasma PCSK9 Levels and Platelet Indices in Patients with Stable Coronary Artery Disease

The Relationship between the Plasma PCSK9 Levels and Platelet Indices in Patients with Stable Coronary Artery Disease

Plasma EMMPRIN levels in acute myocardial infarction and stable coronary artery disease

Von Willebrand Factor Antigen Predicts Response to Double Dose of Aspirin and Clopidogrel by PFA‐100 in Patients Undergoing Primary Angioplasty for St Elevation Myocardial Infarction

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