Vascular and parenchymal AÎ² deposition in the aging dog: correlation with behavior

Colle, Marie-Anne; Hauw, Jean‐Jacques; Crespeau, François; Uchihara, Toshiki; Akiyama, Haruhiko; Checler, Frédéric; Pageat, Patrick; Duykaerts, Charles

doi:10.1016/s0197-4580(00)00113-5

Cited by 132 publications

(119 citation statements)

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“…19 Interestingly, immunoreactivity for both Ab1-42 and Ab1-40 was observed in the cheetah Ab deposits, despite the fact that Ab1-40 is typically found in mature argyrophilic plaques after the accumulation of Ab1-42. 10,21 Although senile plaques have been found in the brains of various species, including nonhuman primates, 14,15,24,49 dogs, 6 cats, 19,32 and bears, 47 it is still unclear whether senile plaques are related to cognitive dysfunction in animals. 8,9,16,39,41 In dogs, accumulation of Ab in the brain is related to neuronal loss of certain area.…”

Section: Discussionmentioning

confidence: 99%

Beta Amyloid Deposition and Neurofibrillary Tangles Spontaneously Occur in the Brains of Captive Cheetahs (Acinonyx jubatus)

2011

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Alzheimer disease is a dementing disorder characterized pathologically by Ab deposition, neurofibrillary tangles, and neuronal loss. Although aged animals of many species spontaneously develop Ab deposits, only 2 species (chimpanzee and wolverine) have been reported to develop Ab deposits and neurofibrillary tangles in the same individual. Here, the authors demonstrate the spontaneous occurrence of Ab deposits and neurofibrillary tangles in captive cheetahs (Acinonyx jubatus). Among 22 cheetahs examined in this study, Ab deposits were observed in 13. Immunostaining (AT8) revealed abnormal intracellular tau immunoreactivity in 10 of the cheetahs with Ab deposits, and they were mainly distributed in the parahippocampal cortex and CA1 in a fashion similar to that in human patients with Alzheimer disease. Ultrastructurally, bundles of straight filaments filled the neuronal somata and axons, consistent with tangles. Interestingly, 2 of the cheetahs with the most severe abnormal tau immunoreactivity showed clinical cognitive dysfunction. The authors conclude that cheetahs spontaneously develop age-related neurodegenerative disease with pathologic changes similar to Alzheimer disease.

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Section: Discussionmentioning

confidence: 99%

Beta Amyloid Deposition and Neurofibrillary Tangles Spontaneously Occur in the Brains of Captive Cheetahs (Acinonyx jubatus)

2011

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“…The phosphorylation sites of tau in the canine brain have been studied, but these have not been fully elucidated. The phosphorylation of tau-1 sites, such as Ser189 and 207 of the amino acid sequence, has been reported in dogs (Wegiel et al 1998), but Colle et al (2000) demonstrated that the brains of aged dogs were not labeled by an antibody that recognizes human phosphorylated Ser194 and Ser202 residues.…”

Section: Physiopathology Of Cognitive Dysfunction Syndrome In Dogsmentioning

confidence: 99%

“…In this sense, and according to some authors, the most effective way to detect this condition is through the use of behavioral questionnaires in the routine geriatric clinic (Head 2001, Head and, obtained from a series of questionnaires that intended to clarify the patients' CDSaffected behavior (Rofina et al 2001. The ARCAD scale (evaluation of age-related cognitive and effective disorders) has also been presented (Colle et al 2000, Pageat 2001, in which the dogs' behavior is analyzed through a "formal questionnaire" that assesses the behavioral categories affected by cognitive and affective disorders, including orientation, recognition of family members and other animals, inappropriate elimination at home, and alterations in sleep-wake patterns.…”

Section: Behavior Diagnosismentioning

confidence: 99%

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Cognitive dysfunction syndrome: updated behavioral and clinical evaluations as a tool to evaluate the well-being of aging dogs

et al. 2014

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Cognitive dysfunction syndrome: updated behavioral and clinical evaluations as a tool to evaluate the well-being of aging dogsSíndrome de disfunción cognitiva: actualización del conocimiento como herramienta para el bienestar animal en perros seniles RESUMENLa mejora en la atención veterinaria, la nutrición y el enriquecimiento del entorno doméstico ha facilitado que cada vez haya un mayor número de perros que vivan su etapa senil. Sin embargo, se debe tener en cuenta que una mayor longevidad implica una mayor prevalencia de problemas cognitivos en nuestras mascotas. A lo largo de su vida geriátrica los perros son más vulnerables a padecer síndromes demenciales neurodegenerativos de carácter progresivo. Una de las enfermedades neurodegenerativas que actualmente está siendo objeto de estudio por su elevada prevalencia es el síndrome de disfunción cognitiva. La enfermedad es una entidad neurocomportamental que se presenta en perros ancianos, caracterizado por un déficit en el aprendizaje, en la memoria y en la conciencia espacial del perro, además de ser un trastorno clínico que tiene un impacto significativo en la vida de los perros de edad avanzada y sus propietarios. La escasez de pruebas diagnósticas de alta confiabilidad que garanticen la presencia o no de la enfermedad, otorga a la identificación temprana de los signos clínicos, un papel crucial para el establecimiento de un buen pronóstico en términos de mejoría y extensión en la calidad de vida de los pacientes afectados. El tratamiento debe dirigirse a frenar la progresión de la pérdida de cognición, mediante la instauración de técnicas y programas que mejoren la actividad física, los aspectos nutricionales y el ambiente del animal. Por lo tanto, son necesarias futuras investigaciones en el conocimiento, control y prevención de esta patología, para disminuir el impacto generado por sus efectos sobre la calidad de vida de los perros y sus propietarios.Palabras clave: síndrome de disfunción cognitiva, perros, proteína β-amiloidea. SUMMARYImprovements in veterinary medicine, nutrition and the enrichment of the domestic environment have helped more dogs reach to their senile phase. However, greater longevity leads to a higher prevalence of cognitive problems in our pets. Throughout their geriatric lives, dogs are more vulnerable to suffering progressive neurodegenerative dementia syndromes. Due to its high prevalence, cognitive dysfunction syndrome is one of the most studied neurodegenerative diseases. This disease is a neurobehavioral entity that presents itself in senile dogs, and it is characterized by a deficit in learning, memory and the dog's spatial awareness. It is a clinical disorder that has a significant impact on older dogs and their owners. There is a lack of reliable diagnostic tests that can guarantee the presence of the disease, provide early identification of the clinical signs of this disease, or establish a prognosis in terms of the recovery and expansion of the quality of life of the affected patient. Treatment should be directed at slowi...

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“…Also like humans, some cortical regions in the dog are more vulnerable to Aβ accumulation than others; the prefrontal cortex shows Aβ plaque pathology in dogs as young as 8 years old (Head et al 2000). Several correlation studies support a link between Aβ accumulation and cognitive deficits in aged dogs (Cummings et al 1996;Colle et al 2000;Head et al 2000;Pugliese et al 2006;Rofina et al 2006), although the results are somewhat mixed, as are the results from human studies.…”

Section: Why Study Aging In Dogs?mentioning

confidence: 99%

Strategies for improving cognition with aging: insights from a longitudinal study of antioxidant and behavioral enrichment in canines

Christie

Opii

Head

2008

AGE

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Studies in humans suggest that lifestyle factors can have a beneficial impact on the risk for developing cognitive decline and dementia with age. There is growing evidence that maintaining a physically and intellectually active lifestyle can positively impact cognitive ability in older individuals. Dietary factors, such as the intake of antioxidants, may also prevent age-related cognitive decline. However, studies in humans are challenging; many variables cannot be controlled, making it difficult for researchers to determine the exact types and quantities of enrichment and dietary factors necessary for positive effects on cognition. Studies in animal models of human aging allow researchers to precisely control such variables, and can be used to assess the mechanisms and molecular pathways underlying any positive effects. Here we review the results of an intervention study using a canine model of human aging. The study was unique in that it compared the effects of dietary antioxidant supplementation alone and in combination with behavioral enrichment. We found that both interventions lead to improvements in cognitive ability in aged dogs; however, combining the treatments preserved cognition to a greater extent than either treatment alone. Overall, the results suggest that antioxidant supplementation and behavioral enrichment target separate yet complementary molecular pathways to improve cognition, and support the idea that combinations of treatments to improve cognition and slow brain aging will produce greater benefits than single interventions.

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Vascular and parenchymal AÎ² deposition in the aging dog: correlation with behavior

Cited by 132 publications

References 40 publications

Beta Amyloid Deposition and Neurofibrillary Tangles Spontaneously Occur in the Brains of Captive Cheetahs (Acinonyx jubatus)

Beta Amyloid Deposition and Neurofibrillary Tangles Spontaneously Occur in the Brains of Captive Cheetahs (Acinonyx jubatus)

Cognitive dysfunction syndrome: updated behavioral and clinical evaluations as a tool to evaluate the well-being of aging dogs

Strategies for improving cognition with aging: insights from a longitudinal study of antioxidant and behavioral enrichment in canines

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