2019
DOI: 10.3233/jad-190339
|View full text |Cite
|
Sign up to set email alerts
|

Vascular and Neurodegenerative Markers for the Prediction of Post-Stroke Cognitive Impairment: Results from the TABASCO Study

Abstract: Background: Stroke is a major cause of cognitive impairment and dementia. However, the underlying mechanisms beyond post-stroke cognitive impairment (PSCI) are not fully explained to date. Objective: We studied the contribution of vascular pathology measures to PSCI, separate from and in conjunction with pathologic markers associated with Alzheimer's disease (AD). Methods: Data from 397 cognitively intact ischemic stroke patients were available. All patients underwent 3T MRI and evaluated for white matter hype… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
34
1

Year Published

2020
2020
2024
2024

Publication Types

Select...
10

Relationship

1
9

Authors

Journals

citations
Cited by 38 publications
(35 citation statements)
references
References 32 publications
0
34
1
Order By: Relevance
“…In line with previous literature, stroke lesion volumes were found to be higher in the major NCD group, with a mean volume of 16.7 vs. 5.8 ml in the normal/mild NCD group. Due to its potential to destroy or compromise tissue vital for cognitive function, stroke lesion volume, as well as WMH load, has been found to be an important independent predictor of post-stroke cognitive deficits (Pendlebury, 2012;Puy et al, 2018;Georgakis et al, 2019), at least for volumes larger than 5 ml (Molad et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…In line with previous literature, stroke lesion volumes were found to be higher in the major NCD group, with a mean volume of 16.7 vs. 5.8 ml in the normal/mild NCD group. Due to its potential to destroy or compromise tissue vital for cognitive function, stroke lesion volume, as well as WMH load, has been found to be an important independent predictor of post-stroke cognitive deficits (Pendlebury, 2012;Puy et al, 2018;Georgakis et al, 2019), at least for volumes larger than 5 ml (Molad et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…As has been the case for TBI and stroke, knowledge of individual genotypes may improve the prediction of differing clinical outcomes of COVID-19 patients. [283][284][285][286] Although individual, nongenetic susceptibility may influence the occurrence or severity of brain injury caused by SARS-Cov-2, variation in susceptibility to SARS-Cov-2 may also be attributable to individual differences in genetic susceptibility factors in infected individuals. Susceptible persons may have impaired innate abilities to fight viruses attributable to suboptimal interferon responses 287 or inability to mount adequate cell-mediated immune responses.…”
Section: Genotypingmentioning
confidence: 99%
“…The pathophysiologic process by which WMH develops includes endothelial dysfunction, disturbance of the microcirculation, and blood-brain barrier breakdown at the level of cerebral arterioles, capillaries, and venules [2, 3]. In acute ischemic stroke, WMH burden has been shown to predict functional and cognitive impairment after the stroke [4-6]. Large vessel occlusion (LVO) strokes are distinct from other forms of ischemic stroke as mechanical thrombectomy, a highly effective therapy in this disease category, is not available to other stroke subtypes [7].…”
Section: Introductionmentioning
confidence: 99%