Vascular Aging in Rodent Models: Contrasting Mechanisms Driving the Female and Male Vascular Senescence

Barros, Pedro Paulo; Costa, Tiago J.; Akamine, Eliana Hiromi; Tostes, Rita C.

doi:10.3389/fragi.2021.727604

Cited by 13 publications

(8 citation statements)

References 287 publications

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“…Most of the resources, now, also have shown that not all the model systems are exactly suitable to study CS in various conditions, disease states and cell/tissue types. For that reason, it is suggested that, instead of choosing one single model, the combination of the results from various models would provide a better understanding of this complex phenomena ( Barros et al, 2021 ). While there are several studies on alternative aging models such as NMR and BMR, there is no sufficient data to fully understand how these unique species adapt CS mechanisms to achieve healthy aging.…”

Section: Clinical Perspectives and Conclusionmentioning

confidence: 99%

Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models

et al. 2022

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Increasing chronological age is the greatest risk factor for human diseases. Cellular senescence (CS), which is characterized by permanent cell-cycle arrest, has recently emerged as a fundamental mechanism in developing aging-related pathologies. During the aging process, senescent cell accumulation results in senescence-associated secretory phenotype (SASP) which plays an essential role in tissue dysfunction. Although discovered very recently, senotherapeutic drugs have been already involved in clinical studies. This review gives a summary of the molecular mechanisms of CS and its role particularly in the development of cardiovascular diseases (CVD) as the leading cause of death. In addition, it addresses alternative research tools including the nonhuman and human models as well as computational techniques for the discovery of novel therapies. Finally, senotherapeutic approaches that are mainly classified as senolytics and senomorphics are discussed.

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Section: Clinical Perspectives and Conclusionmentioning

confidence: 99%

Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models

et al. 2022

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“…This result is supported by the interaction effect of diet and offspring age and requires further investigation. In addition, unique mechanisms drive vascular senescence in males and females [102], so our results may be obscured by our study of exclusively female mice. Another interesting result from our study is the signi cance of the coronary artery velocity (S/D) ratio in 11.5month-old offspring.…”

Section: Discussionmentioning

confidence: 81%

Aging and maternal dietary dietary deficiencies during pregnancy and lactation change cerebral and peripheral blood flow in adult female mice offspring following ischemic stroke to the sensorimotor cortex

Pull¹,

Folk²,

Kang³

et al. 2022

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A maternal diet that provides adequate nutrition during pregnancy and lactation is vital to the neurodevelopment of offspring. One-carbon metabolism plays an important role in the closure of the neural tube of the developing embryo; however, the impact of maternal one-carbon dietary deficiencies on offspring neurological function later in life remains relatively unknown. Stroke is one of the leading causes of death globally, and its prevalence is expected to increase in younger age groups as the incidence of various risk factors for stroke increases (e.g., hypertension). The aim of our study was to determine the impact of maternal nutritional deficiencies on cerebral blood flow and peripheral hemodynamics after ischemic stroke in adult offspring. In this study, adult female C57BL/6J mice were placed on either control (CD), choline (ChDD) or folic acid (FADD) deficient diets for four weeks to deplete stores prior to mating and maintained on the assigned diet during pregnancy and lactation. Female offspring were weaned and transitioned to a CD for the duration of the study. Ischemic stroke was induced in the sensorimotor cortex of 2- and 10-month-old female offspring using the photothrombosis model. Six weeks after induction of stroke, cerebral and peripheral blood flow was measured using the Vevo2100 Pulse Wave Doppler tracing modality. Our data showed that 3.5-month-old female offspring from a ChDD mothers had reduced blood flow in the posterior cerebral artery compared to CD mice; this effect disappeared in older offspring. In 11.5-month-old females we observed changes in peripheral hemodynamics, but not in young animals. Our findings suggest that a maternal dietary deficiency in choline results in reduced cerebral blood flow in adult female offspring after ischemic stroke, but the long-term effects are not present. This result points to the key role of the maternal diet in early life neuro-programming, while emphasizing its effects on both fetal development and long-term cerebrovascular health.

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“…This result is supported by the interaction effect of diet and offspring age and requires further investigation. In addition, unique mechanisms drive vascular senescence in males and females (102), so our results may be obscured by our study of exclusively female mice. Another interesting result from our study is the significance of the coronary artery velocity (S/D) ratio in 11.5-month-old offspring.…”

Section: Discussionmentioning

confidence: 82%

The impact of maternal dietary folic acid or choline deficiencies on cerebral blood flow, cardiac, aortic, and coronary function in young and middle-aged female mouse offspring following ischemic stroke

Pull

Folk

Kang

et al. 2022

Preprint

View full text Add to dashboard Cite

A maternal diet that provides adequate nutrition during pregnancy and lactation is vital to the neurodevelopment of offspring. One-carbon metabolism plays an important role in the closure of the neural tube of the developing embryo; however, the impact of maternal one-carbon dietary deficiencies on offspring neurological function later in life remains relatively unknown. Stroke is one of the leading causes of death globally, and its prevalence is expected to increase in younger age groups as the incidence of various risk factors for stroke increases. The aim of our study was to determine the impact of maternal nutritional deficiencies on cerebral blood flow and peripheral hemodynamics after ischemic stroke in adult offspring. In this study, adult female C57BL/6J mice were placed on either control (CD), choline (ChDD) or folic acid (FADD) deficient diets for four weeks to deplete stores prior to mating and maintained on the assigned diet during pregnancy and lactation. Female offspring were weaned and transitioned to a CD for the duration of the study. Ischemic stroke was induced in the sensorimotor cortex of 2- and 10-month-old female offspring using the photothrombosis model. Six weeks after induction of stroke, cerebral and peripheral blood flow was measured using the Vevo2100 Pulse Wave Doppler tracing modality. Our data showed that 3.5-month-old female offspring from a ChDD mothers had reduced blood flow in the posterior cerebral artery compared to CD mice; this effect disappeared in older offspring. In 11.5-month-old females we observed changes in peripheral hemodynamics, but not in young animals. Our findings suggest that a maternal dietary deficiency in choline results in reduced cerebral blood flow in adult female offspring after ischemic stroke, but the long-term effects are not present. This result points to the key role of the maternal diet in early life neuro-programming, while emphasizing its effects on both fetal development and long-term cerebrovascular health.

show abstract

Vascular Aging in Rodent Models: Contrasting Mechanisms Driving the Female and Male Vascular Senescence

Cited by 13 publications

References 287 publications

Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models

Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models

Aging and maternal dietary dietary deficiencies during pregnancy and lactation change cerebral and peripheral blood flow in adult female mice offspring following ischemic stroke to the sensorimotor cortex

The impact of maternal dietary folic acid or choline deficiencies on cerebral blood flow, cardiac, aortic, and coronary function in young and middle-aged female mouse offspring following ischemic stroke

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