Vascular Aging across the Menopause Transition in Healthy Women

Moreau, Kerrie L.; Hildreth, Kerry L.

doi:10.1155/2014/204390

Cited by 74 publications

(64 citation statements)

References 115 publications

(140 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A reduction of LDL-c of 1.0 mmol/L was associated with a 22% decreased rate of major vascular events in an extensive meta-analysis of individual patient data [45], but this is difference is 2.5 to 10 times larger than menopause-related differences in this study or the study by Matthews et al [6], and in fact more approximate to the differences found with 20 years of chronological age. It may be that the increased risk of cardiovascular events observed in post-menopausal women, the causality of which is a matter of debate in itself [11, 12, 46], is mediated through other pathways such as oxidative stress and inflammation [47]. A previous proposal of lipid screening of women entering the menopausal transition [6] may therefore not prove beneficial.…”

Section: Discussionmentioning

confidence: 99%

Unraveling the associations of age and menopause with cardiovascular risk factors in a large population-based study

Kat

Dam

Onland‐Moret

et al. 2017

BMC Med

115

View full text Add to dashboard Cite

BackgroundAlthough the association between menopause and cardiovascular disease (CVD) risk has been studied extensively, the simultaneous role of chronological aging herein remains underexposed. This study aims to disentangle the relationships of menopausal status and chronological aging with CVD risk factors in the largest study population to date.MethodsIn this cross-sectional study, CVD risk factors were compared between women with a different menopausal status within the same yearly age strata. The study population comprised female participants of the baseline visit of the population-based LifeLines Cohort Study. A total of 63,466 women, aged between 18 and 65 years, was included. Of them, 39,379 women were considered to be premenopausal, 8669 were perimenopausal, 14,514 were naturally postmenopausal, and 904 were surgically postmenopausal.ResultsCompared to postmenopausal women aged 45 years, average total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c) were 0.5 and 0.4 mmol/L higher, respectively, in postmenopausal women aged 50. Systolic and diastolic blood pressure levels were 4 and 1 mmHg higher, respectively. At all ages between 46 and 55 years, and after adjustment for confounders, naturally postmenopausal women had 0.2 to 0.4 mmol/L higher TC and 0.1 to 0.3 mmol/L higher LDL-c levels compared to premenopausal women in the same age range. Systolic blood pressure levels were up to 4 mmHg lower in naturally post- compared to premenopausal women at all ages between 29 and 52 years. Body mass index levels were up to 3.2 kg/m2 higher in women with surgical menopause compared to all other women between the ages 32 and 52 years. All aforementioned results were statistically significant.ConclusionsChronological age and menopausal status are both independently associated with CVD risk factors. Based on the comparatively smaller observed differences associated with menopausal status than with chronological aging, the significance of a more unfavorable lipid profile in a later reproductive stage may be less obvious than previously thought.Electronic supplementary materialThe online version of this article (doi:10.1186/s12916-016-0762-8) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Unraveling the associations of age and menopause with cardiovascular risk factors in a large population-based study

Kat

Dam

Onland‐Moret

et al. 2017

BMC Med

115

View full text Add to dashboard Cite

show abstract

“…Due partially to low estrogen levels, postmenopausal women experience elevated inflammation, which may affect women’s health during aging [93–95]. Indeed, estrogen typically inhibits inflammation, and inflammatory processes play a role in atherosclerosis, cardiovascular disease, and other age-related diseases later in life [94, 96, 97]. These complex relationships affect multiple other hormone mediators and neurotransmitters, providing promising targets for explaining sex differences in mood disorders [91].…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in Depression: Does Inflammation Play a Role?

Derry

Padin

Kuo

et al. 2015

Curr Psychiatry Rep

140

View full text Add to dashboard Cite

Women become depressed more frequently than men, a consistent pattern across cultures. Inflammation plays a key role in initiating depression among a subset of individuals, and depression also has inflammatory consequences. Notably, women experience higher levels of inflammation and greater autoimmune disease risk compared to men. In the current review, we explore the bidirectional relationship between inflammation and depression and describe how this link may be particularly relevant for women. Compared to men, women may be more vulnerable to inflammation-induced mood and behavior changes. For example, transient elevations in inflammation prompt greater feelings of loneliness and social disconnection for women than for men, which can contribute to the onset of depression. Women also appear to be disproportionately affected by several factors that elevate inflammation, including prior depression, somatic symptomatology, interpersonal stressors, childhood adversity, obesity, and physical inactivity. Relationship distress and obesity, both of which elevate depression risk, are also more strongly tied to inflammation for women than for men. Taken together, these findings suggest that women’s susceptibility to inflammation and its mood effects may contribute to sex differences in depression. Depression continues to be a leading cause of disability worldwide, with women experiencing greater risk than men. Due to the depression-inflammation connection, these patterns may promote additional health risks for women. Considering the impact of inflammation on women’s mental health may foster a better understanding of sex differences in depression, as well as the selection of effective depression treatments.

show abstract

“…Overproduction of ROS can affect endothelial function by suppressing nitric oxide synthesis and scavenging nitric oxide, decreasing its overall bioavailability. Moreover, OS due at least in part to the loss of the antioxidant effects of estrogen is a major contributor to the endothelial dysfunction observed in postmenopausal women (Moreau and Hildreth 2014).…”

Section: Introductionmentioning

confidence: 99%

Effect of resistance training with different frequencies and detraining on muscular strength and oxidative stress biomarkers in older women

Padilha

Ribeiro

Fleck

et al. 2015

AGE

View full text Add to dashboard Cite

The aim of this study was to compare the effect of resistance training (RT) performed with different frequencies followed by a detraining period on muscular strength and oxidative stress (OS) biomarkers in older women. Twenty-seven physically independent women (68.8±4.8 years, 69.1±14.3 kg, 156.0±6.5 cm, and 28.3±4.9 to kg.m −2 ) were randomly assigned to perform a RT program for 2 or 3 days per week (G2X=13 vs. G3X=14) for 12 weeks followed by 12 weeks of detraining period. One repetition maximum (1RM) tests were used as measures of muscular strength (three exercises, three attempts for each exercise, 3-5 min of rest between attempts, and 5 min of rest between exercises). Advanced oxidized protein products (AOPP) and total radical-trapping antioxidant parameter (TRAP) were used as oxidative stress indicators. Both groups increased muscular strength after 12 weeks of training (P<0.05) in chest press (G2X=+11.9 % vs. G3X=+27.5 %, P<0.05), knee extension (G2X=+18.4 % vs. G3X=+16.7 %, P > 0.05), and preacher curl (G2X = +37.6 % vs. G3X=+36.7 %, P>0.05). On the other hand, 12 weeks of detraining were not sufficient to eliminate the major effects produced by RT on muscular strength, although a significant decrease (P<0.05) has been observed for chest press (G3X = −9.1 % vs. G2X = −10.2 %, P>0.05), knee extension (G2X=−14.9 % vs. G3X= −12.1 %, P>0.05), and preacher curl (G2X=−20.5 % vs. G3X=−17.4 %, P>0.05). Pre-to post-training, both groups showed significant (P<0.05) increases in TRAP (G2X=+6.9 % vs. G3X=+15.1 %) with no statistical significant difference between the groups (P>0.05), and the scores remained elevated compared to pre-training after 12 weeks of detraining. AOPP was not changed by RT or detraining (P>0.05). The results suggest that a 12-week RT program with a frequency of 2 days per week may be sufficient to improve muscular strength and OS in older women and detraining for 12 weeks does not completely reverse the changes induced by RT.

show abstract

Vascular Aging across the Menopause Transition in Healthy Women

Cited by 74 publications

References 115 publications

Unraveling the associations of age and menopause with cardiovascular risk factors in a large population-based study

Unraveling the associations of age and menopause with cardiovascular risk factors in a large population-based study

Sex Differences in Depression: Does Inflammation Play a Role?

Effect of resistance training with different frequencies and detraining on muscular strength and oxidative stress biomarkers in older women

Contact Info

Product

Resources

About