Vascular ageing: The role of oxidative stress

Puca, Annibale Alessandro; Carrizzo, Albino; Villa, Francesco; Ferrario, Anna; Casaburo, Manuel; Maciąg, Anna; Vecchione, Carmine

doi:10.1016/j.biocel.2012.12.024

Cited by 49 publications

(40 citation statements)

References 27 publications

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“…Vascular ageing is a consequence of redox imbalances [31]. However, it is also well known that ageing per se increases the formation of ROS in endothelial cells [24, 25, 30, 67].…”

Section: Discussionmentioning

confidence: 99%

The Antioxidant Machinery of Young and Senescent Human Umbilical Vein Endothelial Cells and Their Microvesicles

Bodega

Alique

Bohórquez

et al. 2017

Oxidative Medicine and Cellular Longevity

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We examine the antioxidant role of young and senescent human umbilical vein endothelial cells (HUVECs) and their microvesicles (MVs). Proteomic and Western blot studies have shown young HUVECs to have a complete and well-developed antioxidant system. Their MVs also contain antioxidant molecules, though of a smaller and more specific range, specialized in the degradation of hydrogen peroxide and the superoxide anion via the thioredoxin-peroxiredoxin system. Senescence was shown to be associated with a large increase in the size of the antioxidant machinery in both HUVECs and their MVs. These responses might help HUVECs and their MVs deal with the more oxidising conditions found in older cells. Functional analysis confirmed the antioxidant machinery of the MVs to be active and to increase in size with senescence. No glutathione or nonpeptide antioxidant (ascorbic acid and vitamin E) activity was detected in the MVs. Endothelial cells and MVs seem to adapt to higher ROS concentrations in senescence by increasing their antioxidant machinery, although this is not enough to recover completely from the senescence-induced ROS increase. Moreover, MVs could be involved in the regulation of the blood plasma redox status by functioning as ROS scavengers.

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“…Vascular ageing is a consequence of redox imbalances [31]. However, it is also well known that ageing per se increases the formation of ROS in endothelial cells [24, 25, 30, 67].…”

Section: Discussionmentioning

confidence: 99%

The Antioxidant Machinery of Young and Senescent Human Umbilical Vein Endothelial Cells and Their Microvesicles

Bodega

Alique

Bohórquez

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…This is possibly due to lack of existing knowledge on the right balance between ROS species and antioxidant molecules so that normal physiological processes are not hampered. Increase in antioxidants causes increased mortality [66] suggests that defining the fine balance is crucial to discovering efficient therapies against oxidative stress [67]. …”

Section: Balance Between Ros and Antioxidantsmentioning

confidence: 99%

Oxidative Stress and Cardiovascular Aging: Interaction Between NRF-2 and ADMA

Nair

Góngora

2017

CCR

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Background:The concept of antioxidant therapies assumes high importance as oxidative stress is associated with cardiovascular aging via endothelial dysfunction. This review focuses on exploring the interaction between nrf-2 and ADMA in influencing the nitric oxide pathway and cardiovascular function.Objective:A systematic review of literature from 1990 to 2016 was conducted using Pubmed and Google Scholar. The literature suggests a strong influence of nrf-2 activation on up regulation of DDAH I which degrades ADMA, the endogenous inhibitor of nitric oxide synthase. The resulting decrease of ADMA would in turn enhance nitric oxide (NO) production. This would support endothelial function by adequate NO production and homeostasis of endothelial function. Conclusion:As NO production has many positive pleiotropic effects in the cardiovascular system, such an interaction could be utilized for designing molecular therapeutics. The targets for therapy need not be limited to activation of nrf-2. Modulation of molecules downstream such as DDAH I can be used to regulate ADMA levels. Most current literature is supported by animal studies. The concept of antioxidant therapies needs to be tested in well-defined randomized control trials. The biochemical basis of nrf-2 activation needs to be substantiated in human studies.

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“…Oxidative stress is one of the risks of cardiovascular disease (CVD), such as atherosclerosis, and is characterized by the production of free radicals that lead to the oxidation of low density lipoprotein (LDL) (Kovanen and Pentikaïnen, 2003;Puca et al, 2013). It is well known that oxidized LDL accumulates at the site of atherosclerotic lesions (Ramprasath and Jones, 2010), contributing to the formation of macrophage foam cells that induce endothelial dysfunction (Mietus-Snyder et al, 2000), a common marker of CVD.…”

Section: Antioxidant Properties Of Resveratrolmentioning

confidence: 99%

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

Carrizzo

Forte

Damato

et al. 2013

Food and Chemical Toxicology

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167

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a b s t r a c tResveratrol-a natural polyphenolic compound-was first discovered in the 1940s. Although initially used for cancer therapy, it has shown beneficial effects against most cardiovascular and cerebrovascular diseases. A large part of these effects are related to its antioxidant properties. Here we review: (a) the sources, the metabolism, and the bioavailability of resveratrol; (b) the ability of resveratrol to modulate redox signalling and to interact with multiple molecular targets of diverse intracellular pathways; (c) its protective effects against oxidative damage in cardio-cerebro-vascular districts and metabolic disorders such as diabetes; and (d) the evidence for its efficacy and toxicity in humans. The overall aim of this review is to discuss the frontiers in the field of resveratrol's mechanisms, bioactivity, biology, and healthrelated use.

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Vascular ageing: The role of oxidative stress

Cited by 49 publications

References 27 publications

The Antioxidant Machinery of Young and Senescent Human Umbilical Vein Endothelial Cells and Their Microvesicles

The Antioxidant Machinery of Young and Senescent Human Umbilical Vein Endothelial Cells and Their Microvesicles

Oxidative Stress and Cardiovascular Aging: Interaction Between NRF-2 and ADMA

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases

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