Vascular age in a sample of general population of the sanitary area of Toledo (Spain). RICARTO study

Villarín-Castro, A.; Rodríguez-Roca, Gustavo; Segura‐Fragoso, Antonio; Alonso-Moreno, Francisco J.; Rojas-Martelo, Giovani A.; Rodríguez‐Padial, Luis; Fernández-Conde, Julio A.; Lorenzo-Lozano, María-Carmen; Menchén-Herreros, A; Fernández-Martín, Juan; Ricarto, en representación del grupo de trabajo

doi:10.1016/j.medcle.2020.08.017

Cited by 1 publication

(2 citation statements)

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“…In addition, renin-angiotensin-aldosterone system inhibitors are proven to increase the amounts of nicotinamide phosphoribosyltransferase and sirtuin 3, playing a role in controlling vascular aging (5,84). Metformin also exerts an epigenetic action, increasing sirtuin 1 levels, which is one of the molecular pathways proposed by Kreutzenberg et al to explain increased cellular longevity in patients taking this medication (85).…”

Section: Prevention and Treatmentmentioning

confidence: 99%

“…This risk inherent to age is a consequence of vascular aging (VAg), which causes structural and functional changes in the vessels (4). This definition was established to help patients understand their CVR, especially young people with intermediate CVR and poor adherence to preventive measures (5). Recently, studies have shown a correlation between VA and various diseases such as dementia, chronic kidney disease (CKD), and metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Age and vascular aging: an unexplored frontier

González,

Romero-Orjuela,

Rabeya

et al. 2023

Front. Cardiovasc. Med.

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Vascular age is an emerging field in cardiovascular risk assessment. This concept includes multifactorial changes in the arterial wall, with arterial stiffness as its most relevant manifestation, leading to increased arterial pressure and pulsatile flow in the organs. Today, the approved test for measuring vascular age is pulse wave velocity, which has been proven to predict cardiovascular events. Furthermore, vascular phenotypes, such as early vascular aging and “SUPERNOVA,” representing phenotypic extremes of vascular aging, have been found. The identification of these phenotypes opens a new field of study in cardiovascular physiology. Lifestyle interventions and pharmacological therapy have positively affected vascular health, reducing arterial stiffness. This review aims to define the concepts related to vascular age, pathophysiology, measurement methods, clinical signs and symptoms, and treatment.

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Section: Prevention and Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%