Vascular adhesion protein‐1 (VAP‐1) is overexpressed in psoriatic patients

Madej, Aneta; Reich, Adam; Orda, Alina; Szepietowski, Jacek C.

doi:10.1111/j.1468-3083.2006.01869.x

Cited by 36 publications

(29 citation statements)

References 26 publications

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“…These spectra indicated the >95% purities of the prepared compounds. Chemical shifts are given in δ (ppm) relative to TMS (DMSO-d 6 ) or to TSP (D 2 O) as internal standards.…”

Section: Synthesis Of the Novel Hydrazine-like Molecules Generalmentioning

confidence: 99%

Novel Hydrazine Molecules as Tools To Understand the Flexibility of Vascular Adhesion Protein-1 Ligand-Binding Site: Toward More Selective Inhibitors

et al. 2011

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Vascular adhesion protein-1 (VAP-1) belongs to a family of amine oxidases. It plays a role in leukocyte trafficking and in amine compound metabolism. VAP-1 is linked to various diseases, such as Alzheimer's disease, psoriasis, depression, diabetes, and obesity. Accordingly, selective inhibitors of VAP-1 could potentially be used to treat those diseases. In this study, eight novel VAP-1 hydrazine derivatives were synthesized and their VAP-1 and monoamine oxidase (MAO) inhibition ability was determined in vitro. MD simulations of VAP-1 with these new molecules reveal that the VAP-1 ligand-binding pocket is flexible and capable of fitting substantially larger ligands than was previously believed. The increase in the size of the VAP-1 ligands, together with the methylation of the secondary nitrogen atom of the hydrazine moiety, improves the VAP-1 selectivity over MAO.

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“…These spectra indicated the >95% purities of the prepared compounds. Chemical shifts are given in δ (ppm) relative to TMS (DMSO-d 6 ) or to TSP (D 2 O) as internal standards.…”

Section: Synthesis Of the Novel Hydrazine-like Molecules Generalmentioning

confidence: 99%

Novel Hydrazine Molecules as Tools To Understand the Flexibility of Vascular Adhesion Protein-1 Ligand-Binding Site: Toward More Selective Inhibitors

et al. 2011

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“…psoriasis), intestinal blood vessels in inflammatory bowel diseases and synovial blood vessels in inflamed joints (e.g. rheumatoid arthritis) express VAP-1 on their surface [8][9][10][11]. Besides being an adhesion molecule, VAP-1 is also a semicarbazide-sensitive amine oxidase (SSAO) enzyme [12].…”

Section: Introductionmentioning

confidence: 98%

Gallium-labelled peptides for imaging of inflammation

Roivainen

Jalkanen

Nanni

2012

Eur J Nucl Med Mol Imaging

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“…VAP-1 is practically absent from the endothelial surface of normal tissues, but on inflammation, it is translocated from intracellular storage granules to the endothelial cell surface (2). For instance, dermal blood vessels in various inflammatory skin diseases (e.g., psoriasis) and synovial blood vessels in inflamed joints (e.g., rheumatoid arthritis) express VAP-1 on their surface (4)(5)(6)(7). Besides being an adhesion molecule, VAP-1 also is a semicarbazide-sensitive amine oxidase.…”

mentioning

confidence: 99%