Vascular activity of infusion and fractions of Cymbopogon citratus (DC) Stapf. in human arteries

Simões, Daniela M.; Malheiros, Jéssica; Antunes, Pedro E.; Figueirinha, Artur; Cotrim, Maria Dulce; Fonseca, Diogo A.

doi:10.1016/j.jep.2020.112947

Cited by 12 publications

(6 citation statements)

References 11 publications

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“…Experiments were performed on distal segments of ITA harvested from patients undergoing coronary revascularization, with the approval by the Ethics Committee of Faculty of Medicine of University of Coimbra (CE-118/2018) and of Coimbra University Hospitals (reference PC-388/08) and following informed consent. Vascular tissue preparation was carried out as described in [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

Vascular Effects of Polyphenols from Agrimonia eupatoria L. and Role of Isoquercitrin in Its Vasorelaxant Potential in Human Arteries

et al. 2022

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Agrimonia eupatoria L. has been traditionally used for the treatment of inflammatory diseases but also as a hypotensive. To our knowledge, only one study has previously suggested an improvement in vascular endothelial function in diabetic conditions, as the underlying mechanisms and responsible compounds are unknown. In this study, we aimed to assess the direct vascular effects of Agrimonia eupatoria L. in human arteries. The infusion elicited a mild increase in basal vascular tone and a significant potentiation of the adrenergic contraction of 49.18% at 0.02 mg/mL, suggesting the presence of compounds with mild vasoconstrictor activity. In contrast, the ethyl acetate fraction inhibited adrenergic contraction by 80.65% at 2 mg/mL and elicited no effect on basal vascular tone. A potent concentration-dependent vasorelaxation was observed for both the infusion and the ethyl acetate fraction (maximal relaxation above 76% and 47%, respectively). Inhibition of nitric oxide synthase and cyclooxygenase elicited significant decreases in the vasorelaxation to the infusion, as, for the ethyl acetate fraction, only the cyclooxygenase pathway appeared to be involved. Isoquercitrin elicited a vasoactivity consistent with the ethyl acetate fraction, suggesting this is a major component responsible for the vasorelaxant properties of A. eupatoria. Further research is warranted to fully evaluate its vasoprotective properties with therapeutic potential in several conditions, e.g., atherosclerosis.

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Section: Methodsmentioning

confidence: 99%

Vascular Effects of Polyphenols from Agrimonia eupatoria L. and Role of Isoquercitrin in Its Vasorelaxant Potential in Human Arteries

et al. 2022

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“…The tannins, luteolin and apigenin from Cymbopogon citratus (DC) Sapf. produce vasorelaxation, possessing also an antioxidant and anti-inflammatory potential [ 79 ]. This potential is also achieved by flavonoids from Anchusa italica Retz.…”

Section: The Flavonoid’s Mechanism Of Action In Different Pathologmentioning

confidence: 99%

The Effects of Flavonoids in Cardiovascular Diseases

et al. 2020

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Flavonoids are metabolites of plants and fungus. Flavonoid research has been paid special attention to in recent times after the observation of their beneficial effects on the cardiovascular system. These favorable effects are exerted by flavonoids mainly due to their antioxidant properties, which result from the ability to decrease the oxidation of low-density lipoproteins, thus improving the lipid profiles. The other positive effect exerted on the cardiovascular system is the ability of flavonoids to produce vasodilation and regulate the apoptotic processes in the endothelium. Researchers suggested that these effects, including their anti-inflammatory function, are consequences of flavonoids’ potent antioxidant properties, but recent studies have shown multiple signaling pathways linked to them, thus suggesting that there are more mechanisms involved in the beneficial effect of the flavonoids on the human body. This review aims to present the latest data on the classification of these substances, their main mechanisms of action in the human body, and the beneficial effects on the physiological and pathological status of the cardiovascular system.

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“…The vasorelaxant activity of lemongrass extracts and essential oils have been explored in both animal [ 87 , 98 , 99 , 100 ] and human arteries [ 73 ], as well as in human veins [ 72 ], with considerable variability between them. The main results of these studies are summarized in Table 4 .…”

Section: Cardiovascular Activity Of Lemongrass and Citralmentioning

confidence: 99%

“…In human internal thoracic arteries, a water extract of lemongrass, found to contain flavonoids, phenolic acids and tannins, caused different effects depending on the concentration [ 73 ]. Preincubation with 0.002 mg/mL and 2 mg/mL extracts caused a potentiation of NE-mediated contraction, whereas with 0.0002 mg/mL, the contractility was found to decrease.…”

Section: Cardiovascular Activity Of Lemongrass and Citralmentioning

confidence: 99%

“…Alternatively, the 3 mL/kg dose lasted for more than 35 min [ 29 ]. In a similar study, the intravenous administration of a hydroalcoholic lemongrass extract at 5 mg/mL (1 mg in 0.2 mL), corresponding to a 0.8 mg/kg dose, caused a fast and short-lived (less than 2 min) decrease in blood pressure [ 73 ]. The lower duration of effect in this study is probably related to the much lower dose used in this study when compared to that by Carbajal et al (1989), although a rapid metabolism of the bioactive compounds must also be considered.…”

Section: Cardiovascular Activity Of Lemongrass and Citralmentioning

confidence: 99%

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Exploring the Anti-Hypertensive Potential of Lemongrass—A Comprehensive Review

Silva

Bárbara

2022

Biology

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Lemongrass (Cymbopogon citratus (DC) Stapf) is a herb commonly used in folk medicine for many purposes. However, its anti-hypertensive potential has not yet been thoroughly studied. This paper reviews the anti-hypertensive effects of both lemongrass and its main compound citral in in vitro, ex vivo, preclinical and clinical studies. Lemongrass essential oil contains terpenes and their derivatives, whereas extracts contain different classes of polyphenols. Both citral and lemongrass display vasorelaxant activity ex vivo, acting by the promotion of endothelial nitric oxide/prostanoids secretion together with the blockage of calcium channels in the vascular smooth muscle. Citral also displays a negative chronotrope effect, probably due to a centrally mediated enhancement of parasympathetic activity. In both healthy and hypertensive animals, the acute administration of lemongrass results in a decrease in blood pressure, sometimes accompanied by a compensatory increase in heart rate. Similarly, in healthy and hypertensive human subjects, the consumption of lemongrass tea decreases blood pressure. Additionally, a weak/moderate diuretic activity has also been reported in animals and humans, although the mechanisms of action remain elusive. Future preclinical studies are necessary to identify other compounds with anti-hypertensive activity and additional pharmacological pathways. Although well tolerated, the safety profile of lemongrass should be better characterized.

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Vascular activity of infusion and fractions of Cymbopogon citratus (DC) Stapf. in human arteries

Cited by 12 publications

References 11 publications

Vascular Effects of Polyphenols from Agrimonia eupatoria L. and Role of Isoquercitrin in Its Vasorelaxant Potential in Human Arteries

Vascular Effects of Polyphenols from Agrimonia eupatoria L. and Role of Isoquercitrin in Its Vasorelaxant Potential in Human Arteries

The Effects of Flavonoids in Cardiovascular Diseases

Exploring the Anti-Hypertensive Potential of Lemongrass—A Comprehensive Review

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