Vasa vasorum in the tunica media and tunica adventitia of the porcine aorta

Tonar, Zbyněk; Tomášek, Petr; Loskot, Petr; Janáček, Jiřı́; Králíčková, Milena; Witter, Kirsti

doi:10.1016/j.aanat.2016.01.008

Cited by 22 publications

(19 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alternatively, the vasa vasorum were not seen in the tunica media of the abdominal aorta in dolphins although the media of this segment exceeded the 29 lamellar units, as is observed in humans (Wolinsky & Glagov, ). Similar results were obtained by Tonar et al, , who found greater vasa‐vasorum density in thoracic than in abdominal aorta in pigs. Both circumstances, more than 29 laminar units and a lacking of vasa vasorum in the tunica media of the abdominal aorta have been considered factors that may influence the susceptibility of the aortic wall to vascular disease in humans (Wolinsky & Glagov, ).…”

Section: Discussionsupporting

confidence: 90%

Morphological structure of the aortic wall in three Delphinid species with shallow or intermediate diving habits: Evidence for diving adaptation

Mompeó

Pérez

Fernández

et al. 2020

Journal of Morphology

View full text Add to dashboard Cite

Some modifications in the vascular system of marine mammals provide adaptive advantages for diving. This study analyses the organisation of the aortic wall in dolphins, observing artery changes in volume and blood pressure for diving behaviour. Samples of three aortic segments (ascending, thoracic and abdominal) of three dolphin species were processed for histological and morphometric studies. The three dolphin species used, striped dolphin (Stenella coeruleoalba), Atlantic spotted dolphin (Stenella frontalis) and common dolphin (Delphinus delphis), have shallow or intermediate diving habits. Our results indicated that the components of the aortic wall of the dolphins had different dispositions in the three selected segments. The aortic wall decreased in thickness along its length due to a loss of the lamellar units in the tunica media and a thinning of the main elements of the lamellar units along the artery. The life stage had little influence on the thickness of the aortic wall except for the ascending aorta. The weight, body length, species or sex of the specimen did not significantly influence the thickness of the wall or the lamellar units. In summary, the histological and morphometric aortic structure in dolphins, in relation to the studied parameters, seems to be similar to that previously described of terrestrial mammals such as pigs, except for a larger difference in the proportion of lamellar units between the ascending and thoracic segments.

show abstract

Section: Discussionsupporting

confidence: 90%

Morphological structure of the aortic wall in three Delphinid species with shallow or intermediate diving habits: Evidence for diving adaptation

Mompeó

Pérez

Fernández

et al. 2020

Journal of Morphology

View full text Add to dashboard Cite

show abstract

“…Anatomic data on aortic VV have been reported in several species, including pigs. 16 Main vessels that enter the adventitia are distal branches of intercostal, lumbar, mesenteric, brachiocephalic, and coronary arteries that grow by angiogenesis during development. 17 This has been confirmed by showing that experimental ligation of intercostal arteries results in necrosis of the media and some adventitial tissue in the aortic segment perfused by the ligated artery.…”

Section: Blood Supply In the Adventitia (Vv)mentioning

confidence: 99%

“…15 Histologic studies usually include arterioles, capillaries, and veins in density counts using standard histology and recently using antigen signatures for ECs, such as von Willebrand factor, CD31, and CD34. 16 In vivo microcomputed tomography imaging has also been used to show the three-dimensional nature of the VV. 18 Although nutrition of thin-walled normal blood vessels occurs through filtration from the lumen and diffusion through the intima and media, the VV is required for the transportation of nutrients and oxygen to the adventitia and the outer media, where the media is normally thick because of numerous lamellar units.…”

Section: Blood Supply In the Adventitia (Vv)mentioning

confidence: 99%

Recent Developments in Vascular Adventitial Pathobiology

Tinajero

Gotlieb

2020

The American Journal of Pathology

100

View full text Add to dashboard Cite

The adventitia, the outer layer of the blood vessel wall, may be the most complex layer of the wall and may be the master regulator of wall physiology and pathobiology. This review proposes a major shift in thinking to apply a functional lens to the adventitia rather than only a structural lens. Human and experimental in vivo and in vitro studies show that the adventitia is a dynamic microenvironment in which adventitial and perivascular adipose tissue cells initiate and regulate important vascular functions in disease, especially intimal hyperplasia and atherosclerosis. Although well away from the bloodwall interface, where much pathology has been identified, the adventitia has a profound influence on the population of intimal and medial endothelial, macrophage, and smooth muscle cell function. Vascular injury and dysfunction of the perivascular adipose tissue promote expansion of the vasa vasorum, activation of fibroblasts, and differentiation of myofibroblasts. This regulates further biologic processes, including fibroblast and myofibroblast migration and proliferation, inflammation, immunity, stem cell activation and regulation, extracellular matrix remodeling, and angiogenesis. A debate exists as to whether the adventitia initiates disease or is just an important participant. We describe a mechanistic model of adventitial function that brings together current knowledge and guides the design of future investigations to test specific hypotheses on adventitial pathobiology.

show abstract

“…Tonar et al demonstrated the vasa vasorum density is higher in the tunica media and penetrates deeper towards the lumen in the thoracic aorta as compared to the abdominal aorta in porcine tissue. 14 Furthermore, Federspiel et al used immunohistochemical staining and confirmed these findings in human thoracic aorta. 15 Collagen primarily provides tensile strength and in the adventitia collagen types I and III predominate.…”

Section: Biology Of the Thoracic Aortamentioning

confidence: 82%

Bio-chemo-mechanics of the thoracic aorta

2021

View full text Add to dashboard Cite

The pathophysiology of thoracic aortic aneurysms and dissections are poorly understood, despite high mortality associated with the diseases. An evidence review was conducted to examine the biomechanical, chemical and genetic factors involved in thoracic aortic pathology. The composition of connective tissue and smooth muscle cell action can mediate important mechanical properties that allow the thoracic aorta to withstand and transmit pressures. Genetic syndromes can affect connective tissue and signalling proteins that interrupt smooth muscle function, leading to tissue failure. There are complex interplaying factors that maintain thoracic aortic function in health and disrupt in disease, signifying an area for extensive research.

show abstract

Vasa vasorum in the tunica media and tunica adventitia of the porcine aorta

Cited by 22 publications

References 58 publications

Morphological structure of the aortic wall in three Delphinid species with shallow or intermediate diving habits: Evidence for diving adaptation

Morphological structure of the aortic wall in three Delphinid species with shallow or intermediate diving habits: Evidence for diving adaptation

Recent Developments in Vascular Adventitial Pathobiology

Bio-chemo-mechanics of the thoracic aorta

Contact Info

Product

Resources

About