Varying Perceived Social Threat Modulates Pain Behavior in Male Mice

Langford, Dale J.; Tuttle, Alexander H.; Briscoe, Ciara; Harvey-Lewis, Colin; Baran, Inna; Gleeson, Patrick K.; Fischer, David; Buonora, Michele; Sternberg, Wendy F.; Mogil, Jeffrey S.

doi:10.1016/j.jpain.2010.06.003

Cited by 64 publications

(60 citation statements)

References 40 publications

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“…Social interaction can also affect pain behaviour in male mice. When mice were tested in a dyad in which only one was injected with acetic acid, either stress-induced analgesia or stress-induced hyperalgesia was observed, depending on the threat level dictated by facets of the testing situation 45 ; these effects are only seen in unfamiliar male mice.…”

Section: Male Onlymentioning

confidence: 99%

Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon

2012

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| A clear majority of patients with chronic pain are women; however, it has been surprisingly difficult to determine whether this sex bias corresponds to actual sex differences in pain sensitivity. A survey of the currently available epidemiological and laboratory data indicates that the evidence for clinical and experimental sex differences in pain is overwhelming. Various explanations for this phenomenon have been given, ranging from experiential and sociocultural differences in pain experience between men and women to hormonally and genetically driven sex differences in brain neurochemistry. PERSPECTIVES NATURE REVIEWS | NEUROSCIENCE VOLUME 13 | DECEMBER 2012 | 859

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Section: Male Onlymentioning

confidence: 99%

Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon

2012

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“…We have previously shown that in both mice (15) and humans (16) the mere proximity of a stranger conspecific can produce measurable increases in adrenal stress hormones. We first confirmed that plasma corticosterone levels in the TCOT were increased in strangers as compared with siblings (Time × Condition), F(3, 91) = 6.5, P = 0.001; significantly so at 30-60 min ( Fig.…”

Section: Significancementioning

confidence: 99%

Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes

Tuttle

Tansley

Dossett

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Existing assays of social interaction are suboptimal, and none measures propinquity, the tendency of rodents to maintain close physical proximity. These assays are ubiquitously performed using inbred mouse strains and mutations placed on inbred genetic backgrounds. We developed the automatable tube cooccupancy test (TCOT) based on propinquity, the tendency of freely mobile rodents to maintain close physical proximity, and assessed TCOT behavior on a variety of genotypes and social and environmental conditions. In outbred mice and rats, familiarity determined willingness to cooccupy the tube, with siblings and/or cagemates of both sexes exhibiting higher cooccupancy behavior than strangers. Subsequent testing using multiple genotypes revealed that inbred strain siblings do not cooccupy at higher rates than strangers, in marked contrast to both outbred and rederived wild mice. Mutant mouse strains with "autistic-like" phenotypes (Fmr1 −/y and Eif4e Ser209Ala) displayed significantly decreased cooccupancy.propinquity | autism | social interaction | rodent behavior | genetics

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“…Self-report and behavioral studies of social factors in pain experience are also supported by the burgeoning field of social neuroscience and experimental studies of social factors modulating pain in non-human animals (Langford et al, 2010a;Langford et al, 2006;Langford et al, 2011).…”

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confidence: 99%

A biopsychosocial formulation of pain communication.

Hadjistavropoulos¹,

Craig²,

Duck³

et al. 2011

Psychological Bulletin

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398

366

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We present a detailed framework for understanding the numerous and complicated interactions among psychological and social determinants of pain through examination of the process of pain communication. The focus is on an improved understanding of immediate dyadic transactions during painful events in the context of broader social phenomena. Fine-grain consideration of social transactions during pain leads to an appreciation of sociobehavioral events affecting both suffering persons as well as caregivers. Our examination considers knowledge from a variety of perspectives, including clinical health psychology, social and developmental processes, evolutionary psychology, communication studies, and behavioral neuroscience.

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Varying Perceived Social Threat Modulates Pain Behavior in Male Mice

Cited by 64 publications

References 40 publications

Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon

Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon

Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes

A biopsychosocial formulation of pain communication.

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