Various scoring systems evaluating histologic features of chronic hepatitis C treated with interferon

Ikawa, Hirotsugu; Hayashi, Yoshitake; Ninomiya, Toshiaki; Yano, Yoshihiko; Nakaji, Miyuki; Nagano, Hidenobu; Seo, Yasushi; Kumon, Yoshiko; Yoon, Seitetsu; Kasuga, Masato; Itoh, Hiroshi; Ohbayashi, Chiho

doi:10.1053/hupa.2001.27108

Cited by 9 publications

(3 citation statements)

References 14 publications

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“…Two independent pathologists, experienced in hepatopathology, assessed the inflammation activity and stages of fibrosis, iron deposits and steatosis according to Scheuer score. 12 …”

Section: Methodsmentioning

confidence: 99%

Differences in sequences between HBV-relaxed circular DNA and covalently closed circular DNA

Rybicka

Woziwodzka

Romanowski

et al. 2017

Emerging Microbes & Infections

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The hepatitis B virus (HBV) genome exists in two forms: circular covalently closed DNA (cccDNA) and relaxed circular DNA (RCDNA). Here, we investigated the presence of differences in the sequences of both forms in paired samples of serum and liver tissue. The serum and liver biopsy samples were collected at the same time from 67 chronically infected patients. The genotyping of the RCDNA and cccDNA was performed using mass spectrometry analysis. The HBV mutations located in the HBV pol (P) and the HBV basal core promoter/pre-core (BCP/PC) regions were included. The BCP/PC and P sequences of the RCDNA extracted from liver and blood samples were different in 39% and 16% of patients, respectively. Differences were also found between RCDNA and cccDNA extracted from the same liver specimen. Moreover, the cccDNA BCP/PC region sequence had an impact on various virological and clinical parameters. We demonstrated that there are differences between the RCDNA and cccDNA sequences that were extracted from the same liver tissue. However, further investigations are needed to analyze whether the mutations in the cccDNA are conserved and whether cccDNA serves as a ‘mutation storage’ pool for HBV. This result could have profound implications for the subsequent therapy choices for treatment-experienced patients.

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“…Two independent pathologists, experienced in hepatopathology, assessed the inflammation activity and stages of fibrosis, iron deposits and steatosis according to Scheuer score. 12 …”

Section: Methodsmentioning

confidence: 99%

Differences in sequences between HBV-relaxed circular DNA and covalently closed circular DNA

Rybicka

Woziwodzka

Romanowski

et al. 2017

Emerging Microbes & Infections

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“…Slight intralobular change was seen in the ID group. The modified histological activity index (HAI) grading score, 13 which is used worldwide to evaluate inflammation of the liver, was 6 in the ID group. On the contrary, histological findings of the liver in the rats with ED showed minimal change, with a modified HAI score of 0.…”

Section: Histological Findingsmentioning

confidence: 99%

Short-term effects of external and internal biliary drainage on liver and cellular immunity in experimental obstructive jaundice

Mizuguchi

Ajiki

Onoyama

et al. 2004

J Hepatobiliary Pancreat Surg

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“…Posteriormente Ishak y col modifican el knodell e introducen un espectro más amplio y completo del grado de necroinflamación 26 . Ikawa y col sugieren que estos dos últimos esquemas resultan más completos y reproducibles ya que el knodell no separa aspectos como el grado y el estadio, los tipos de necrosis hepatocitaria ni la fibrosis portoportal de la fibrosis porto-central 27 . En 1996 el grupo METAVIR realiza un algoritmo para graduar la actividad en la hepatitis crónica C. Únicamente utilizan 2 variables, la necrosis en sacabocados y la necrosis lobulillar 28 .…”

Section: Las Alteraciones Hepatocitariasunclassified

Infección crónica por el VHC

Iñarrairaegui

Elizalde

Echeverría³

et al. 2004

Anales Sis San Navarra

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Various scoring systems evaluating histologic features of chronic hepatitis C treated with interferon

Cited by 9 publications

References 14 publications

Differences in sequences between HBV-relaxed circular DNA and covalently closed circular DNA

Differences in sequences between HBV-relaxed circular DNA and covalently closed circular DNA

Short-term effects of external and internal biliary drainage on liver and cellular immunity in experimental obstructive jaundice

Infección crónica por el VHC

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