Various manufacturing methods and ideal properties of scaffolds for tissue engineering applications

Suamte, Laldinthari; Tirkey, Akriti; Barman, Jugal; Babu, Punuri Jayasekhar

doi:10.1016/j.smmf.2022.100011

Cited by 51 publications

(51 citation statements)

References 188 publications

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“…In order to prepare various CFCOs containing varying CS-g-PLA weight concentrations (20,30,40, and 50 wt%), the following experimental protocol depicted in Scheme 1 was employed. Initially, PLA pellets were ground into powder form via cryogenic grinding and dried under vacuum for 12 h at 50 C in a Shel Lab oven (Model 1445, Sheldon Manufacturing Inc., United States).…”

Section: Preparation Of the Cfcomentioning

confidence: 99%

“…17,19,16 The literature describes a wide range of porous scaffold fabrication techniques. [20][21][22][23][24][25][26][27][28][29][30] These techniques can be broadly classified into two categories: conventional and additive manufacturing techniques. 20 Conventional techniques comprise methods such as solvent-casting and particulateleaching, 21 freeze-drying and phase separation, 22 gas foaming, 23 and electrospinning.…”

Section: Introductionmentioning

confidence: 99%

“…[20][21][22][23][24][25][26][27][28][29][30] These techniques can be broadly classified into two categories: conventional and additive manufacturing techniques. 20 Conventional techniques comprise methods such as solvent-casting and particulateleaching, 21 freeze-drying and phase separation, 22 gas foaming, 23 and electrospinning. 24 Additive manufacturing techniques involve techniques like fused deposition modeling (FDM), 25,26 laser-assisted bioprinting, 27 binder jetting, 28 stereolithography, 29 and inkjet printing.…”

Section: Introductionmentioning

confidence: 99%

“…The literature describes a wide range of porous scaffold fabrication techniques 20–30 . These techniques can be broadly classified into two categories: conventional and additive manufacturing techniques 20 .…”

Section: Introductionmentioning

confidence: 99%

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A novel foaming technique to develop functional open‐cell polylactic acid scaffolds for bone tissue engineering

Osman

Virgilio

Rouabhia

et al. 2023

J of Applied Polymer Sci

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The aim of this study was to develop a solvent-free polylactic acid (PLA) opencell porous scaffold for bone tissue engineering using compression molding and a new chemical foaming compound, that we named CFCO. The latter is composed of a blend of PLA and azodicarbonamide (ADA) as a chemical foaming agent, with the addition of chitosan-grafted PLA (CS-g-PLA) copolymer at various concentrations. The novelty of this approach is that during the foaming, that is, during the decomposition of the ADA foaming agent, the CS-g-PLA copolymer is projected toward the surface of the pores and strongly adhere there, which was confirmed by scanning electron microscopy and confocal microscopy. The results showed that at 6.90 wt% of CS-g-PLA copolymer, the immobilization of the latter on the surface of the pores led to a 52% increase in cell proliferation compared to the pure PLA control sample and a 26% increase compared to scaffolds that had 10 wt% of CS-g-PLA copolymer dispersed throughout the entire PLA matrix. K E Y W O R D S chemical foaming compound (CFCO), chitosan-g-PLA copolymer, open-cell porous scaffold, osteoblast, osteoblast cell adhesion and proliferation

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Section: Preparation Of the Cfcomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A novel foaming technique to develop functional open‐cell polylactic acid scaffolds for bone tissue engineering

Osman

Virgilio

Rouabhia

et al. 2023

J of Applied Polymer Sci

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“…Specifically, this technique has been extensively studied in developing drug delivery systems with precisely controlled release rates and targeting capabilities, [ 10–13 ] as well as scaffold materials for tissue engineering with desired mechanical properties. [ 14,15 ] Hence, the development of bioinspired hybrid particulate networks through particle‐mediated self‐assembly has provided a promising approach for enhancing the mechanical and biodegradation properties of both biological and synthetic materials. [ 16–19 ]…”

Section: Introductionmentioning

confidence: 99%

Particle Network Self‐Assembly of Similar Size Sub‐Micron Calcium Alginate and Polystyrene Particles Atop Glass

Onuh

Bar‐On

Manor

2023

Macromolecular Bioscience

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Particle‐mediated self‐assembly, such as nanocomposites, microstructure formation in materials, and core‐shell coating of biological particles, offers precise control over the properties of biological materials for applications in drug delivery, tissue engineering, and biosensing. We study the assembly of similar‐sized calcium alginate (CAG) and polystyrene sub‐micron particles in an aqueous sodium nitrate solution as a model for particle‐mediated self‐assembly of biological and synthetic mixed particle species. The objective is to reinforce biological matrixes by incorporating synthetic particles to form hybrid particulate networks with tailored properties. By varying the ionic strength of the suspension, we alter the energy barriers for particle attachment to each other and to a glass substrate that results from colloidal surface forces. The particles do not show monotonic adsorption trend to glass with ionic strength. Hence, apart from DLVO theory—van der Waals and electrostatic interactions—we further consider solvation and bridging interactions in our analysis of the particulate adsorption‐coagulation system. CAG particles, which support lower energy barriers to attachment relative to their counterpart polystyrene particles, accumulate as dense aggregates on the glass substrate. Polystyrene particles adsorb simultaneously as detached particles. At high electrolyte concentrations, where electrostatic repulsion is largely screened, the mixture of particles covers most of the glass substrate; the CAG particles form a continuous network throughout the glass substrate with pockets of polystyrene particles. The particulate structure is correlated with the adjustable energy barriers for particle attachment in the suspension.This article is protected by copyright. All rights reserved

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An Overview of the Electrospinning of Polymeric Nanofibers for Biomedical Applications Related to Drug Delivery

CeCe,

Jining,

Islam

et al. 2023

Adv Eng Mater

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Electrospinning is a prominent technique for micro/nanofiber production and has received significant attention in the 21st century. It enables the production of ultrafine fibers using a variety of polymers, including synthetic, natural, and hybrid materials. Electrospun nanofibers (NFs) possess unique properties such as a high surface‐to‐volume ratio, tunable pore structures, and customizable composition, making them highly desirable in various fields such as biomedical science, textiles, sensors, filters, energy, and packaging. Here, particular attention will be given to the application of NFs in biomedical fields. The use of NFs for the delivery of drugs, growth factors, proteins, nanoparticles (NPs), etc., holds significant promise in the field of biomedical science. To combine these compounds with NFs, various electrospinning techniques have been developed with outstanding improvements, and based on the requirements of the application type, different electrospinning processes are favored. In this review, the most common drug loading methods into NFs, generally used synthetic/natural polymers for NF production, and their application in drug delivery systems, tissue engineering, and wound dressing will be mentioned. Finally, challenges and future perspectives for above mentioned biomedical applications were discussed.This article is protected by copyright. All rights reserved.

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Various manufacturing methods and ideal properties of scaffolds for tissue engineering applications

Cited by 51 publications

References 188 publications

A novel foaming technique to develop functional open‐cell polylactic acid scaffolds for bone tissue engineering

A novel foaming technique to develop functional open‐cell polylactic acid scaffolds for bone tissue engineering

Particle Network Self‐Assembly of Similar Size Sub‐Micron Calcium Alginate and Polystyrene Particles Atop Glass

An Overview of the Electrospinning of Polymeric Nanofibers for Biomedical Applications Related to Drug Delivery

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