Various levels of circulating exosomal total-miRNA and miR-210 hypoxamiR in different forms of pregnancy hypertension

Bíró, Orsolya; Alasztics, Bálint; Molvarec, Attila; Joó, József Gábor; Nagy, Bálint; Rigó, János

doi:10.1016/j.preghy.2017.09.002

Cited by 63 publications

(47 citation statements)

References 43 publications

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“…The total miRNA concentration in exosome samples was six times higher in sever PE and three times higher in moderate PE groups compared with normotensive group. Moreover, exosomal has‐miR‐210‐3p expression was higher in both sever PE and moderate PE groups and in sever PE higher than moderate PE group …”

Section: Epigenetic Changes In Pementioning

confidence: 90%

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The role of epigenetic changes in preeclampsia

et al. 2019

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Preeclampsia (PE) is a disorder affecting 2–10% of pregnancies and has a major role for perinatal and maternal mortality and morbidity. PE can be occurred by initiation of new hypertension combined with proteinuria after 20 weeks gestation, as well as various reasons such as inflammatory cytokines, poor trophoblast invasion can be related with PE disease. Environmental factors can cause epigenetic changes including DNA methylation, microRNAs (miRNAs), and histone modification that may be related to different diseases such as PE. Abnormal DNA methylation during placentation is the most important epigenetic factor correlated with PE. Moreover, changes in histone modification like acetylation and also the effect of overregulation or low regulation of miRNAs or long noncoding RNAs on variety signaling pathways can be resulted in PE. The aim of this review is to describe of studies about epigenetic changes in PE and its therapeutic strategies.

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Section: Epigenetic Changes In Pementioning

confidence: 90%

“…Moreover, exosomal has-miR-210-3p expression was higher in both sever PE and moderate PE groups and in sever PE higher than moderate PE group. 106…”

Section: Has-mir-210 Has-mir-517c Changes In Exosome Ago-bound Plamentioning

confidence: 99%

The role of epigenetic changes in preeclampsia

et al. 2019

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“…A number of publications have addressed placental EVs and their potential role in pregnancy and its complications . Several ex vivo (eg, placental perfusion) and in vivo systems have been used as a source of EVs.…”

Section: Discussionmentioning

confidence: 99%

Extracellular vesicles generated by placental tissues ex vivo: A transport system for immune mediators and growth factors

Fitzgerald

Gomez‐Lopez

Erez

et al. 2018

American J Rep Immunol

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A system of ex vivo placental villous and amnion tissues can be used as an adequate model to study placenta metabolic activity in normal and complicated pregnancies, in particular to characterize EVs by their surface markers and by encapsulated proteins. Establishment and benchmarking the placenta ex vivo system may provide new insight in the functional status of this organ in various placental disorders, particularly regarding the release of EVs and cytokines. Such EVs may have a prognostic value for pregnancy complications.

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“…Numerous studies have shown that miR‐210 is upregulated and regulated by HIF in a variety of tumors and cardiovascular diseases and is associated with oxidative stress, mitochondrial metabolism, angiogenesis, DNA repair, and cell survival (Devlin, Greco, Martelli, & Ivan, ). MiR‐210 was found to be consistently upregulated in the placenta and plasma of PE in most studies (Biro et al, ; Enquobahrie et al, ; Munaut et al, ; Noack et al, ; Xu et al, ). Laser microdissection analysis revealed that miRNA‐210 is predominantly present in syncytiotrophoblasts (Ishibashi et al, ).…”

Section: Mirna Involved In Pementioning

confidence: 95%

Roles of microRNAs in preeclampsia

Lü

et al. 2018

Journal Cellular Physiology

139

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Preeclampsia (PE) is a complex disorder that is characterized by hypertension and proteinuria after the 20th week of pregnancy, and it causes most neonatal morbidity and perinatal mortality. Most studies suggest that placental dysfunction is the main cause of PE. However, genetic factors, immune factors, and systemic inflammation are also related to the pathophysiology of this syndrome. Thus far, the exact pathogenesis of PE is not yet fully understood, and intense research efforts are focused on PE to elucidate the pathophysiological mechanisms. MicroRNAs (miRNAs) refer to small single-stranded and noncoding molecules that can negatively regulate gene expression, and miRNA regulatory networks play an important role in diverse pathological processes. Many studies have confirmed deregulated miRNA in pregnant patients with PE, and the function and mechanism of these differentially expressed miRNA are gradually being revealed. In this review, we summarize the current research about miRNA involved in PE, including placenta-specific miRNA, their predictive value, and their function in the development of PE. This review will provide fundamental evidence of miRNA in PE, and further studies are necessary to explore the roles of miRNA in the early diagnosis and treatment of PE.

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Various levels of circulating exosomal total-miRNA and miR-210 hypoxamiR in different forms of pregnancy hypertension

Abstract: The level of circulating exosomal total-miRNA and hsa-miR-210 was elevated in women with PE, and it was higher in the severe form. We showed that hsa-miR-210 is secreted via exosomes, which may have a role in the pathomechanism of the disease.

Cited by 63 publications

References 43 publications

The role of epigenetic changes in preeclampsia

The role of epigenetic changes in preeclampsia

Extracellular vesicles generated by placental tissues ex vivo: A transport system for immune mediators and growth factors

Roles of microRNAs in preeclampsia

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