Various Fractions of Alcoholic Extracts from Dendrobium nobile Functionalized Antioxidation and Antiaging in D-Galactose-Induced Aging Mice

Gao, Xiaoping; Li, Jun; Luo, Yuanning; Lei, Yu; Long, Wenwen; Wang, Kai; Zhou, Jing; Lei, Ming; Yang, Nan; Zou, Hongyu; Huang, Feihong; Wan, Runlan

doi:10.31083/j.fbl2711315

Cited by 5 publications

(6 citation statements)

References 39 publications

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“…At the phylum level, the Firmicutes/Bacteriodota value (F/B) has been proposed as an indicator of the overall status of the intestine microbiota. According to the previous study, the F/B in aging mice increased significantly compared with young individuals, while CPP-1 supplementation decreased the F/B value, which was consistent with previous studies [ 31 , 49 ]. Bacteriodota first converts pyruvate to acetyl-CoA before using phosphor-acetyltransferase and acetate kinase to produce acetic acids [ 50 ].…”

Section: Discussionsupporting

confidence: 91%

A Pectic Polysaccharide from Codonopsis pilosula Alleviates Inflammatory Response and Oxidative Stress of Aging Mice via Modulating Intestinal Microbiota-Related Gut–Liver Axis

Zou,

Yan,

et al. 2023

Antioxidants

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Aging is a biological process that leads to the progressive deterioration and loss of physiological functions in the human body and results in an increase in morbidity and mortality, and aging-related disease is a major global problem that poses a serious threat to public health. Polysaccharides have been shown to delay aging by reducing oxidative damage, suppressing inflammatory responses, and modulating intestinal microbiota. Our previous studies have shown that polysaccharide CPP-1 extracted from the root of Codonopsis pilosula possesses noticeable anti-oxidant activity in vitro. Thus, in our study, we tested the anti-aging effect of CPP-1 in naturally aging mice (in vivo). Eighteen C57/BL mice (48-week-old, male) were divided into a control group, high-dose CPP-1 group (20 mg/mL), and low-dose CPP-1 group (10 mg/mL). We discovered that CPP-1 can exert a reparative effect on aging stress in the intestine and liver, including alleviating inflammation and oxidative damage. We revealed that CPP-1 supplementation improved the intestinal microbiota composition and repaired the intestinal barrier in the gut. Furthermore, CPP-1 was proved to modulate lipid metabolism and repair hepatocyte injury in the liver by influencing the enterohepatic axis associated with the intestinal microbiota. Therefore, we concluded that CPP-1 prevents and alleviates oxidative stress and inflammatory responses in the intestine and liver of aging mice by modulating the intestinal microbiota-related gut–liver axis to delay aging.

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Section: Discussionsupporting

confidence: 91%

A Pectic Polysaccharide from Codonopsis pilosula Alleviates Inflammatory Response and Oxidative Stress of Aging Mice via Modulating Intestinal Microbiota-Related Gut–Liver Axis

Zou,

Yan,

et al. 2023

Antioxidants

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“…(Poly)phenol-rich extracts and botanicals, such as blackberry and blueberry anthocyanin-rich extracts [78,79], have been shown to restore gut dysbiosis, increase the production of SCFAs, improve cognitive performance and improve antioxidant activities in the brain. Overall, (poly)phenols improve gut microbiome composition by increasing microbial abundance and diversity and by restoring a gut microbial balance between the Firmicutes/Bacteroidetes ratio [74,[80][81][82].…”

Section: (Poly)phenols Gut Microbiome Modulation and Related Brain He...mentioning

confidence: 99%

“…This is notably illustrated by an a posteriori increase in neuroinflammation, which was observed following menopause and the associated fall in oestrogen levels [109,110]. In models of (neuro)inflammatory diseases, e.g., direct administration of amyloid beta Aβ1-42 peptide [111], D-galactose [68,[80][81][82]99,104,105] or by other neurotoxins [111], oxidative stress, inflammation and mitochondrial dysfunction occur, usually in parallel to an abnormal gut ecosystem. This is of major importance as it validates the bidirectionality of the gut-brain axis, with induced neuro-disorders causing deleterious changes at the level of the microbiome.…”

Section: Insight Into Associated Molecular Mechanismsmentioning

confidence: 99%

Dietary (Poly)phenols and the Gut–Brain Axis in Ageing

Láng,

McArthur,

Lazar

et al. 2024

Nutrients

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As the population ages, the incidence of age-related neurodegenerative diseases is rapidly increasing, and novel approaches to mitigate this soaring prevalence are sorely needed. Recent studies have highlighted the importance of gut microbial homeostasis and its impact on brain functions, commonly referred to as the gut–brain axis, in maintaining overall health and wellbeing. Nonetheless, the mechanisms by which this system acts remains poorly defined. In this review, we will explore how (poly)phenols, a class of natural compounds found in many plant-based foods and beverages, can modulate the gut–brain axis, and thereby promote neural health. While evidence indicates a beneficial role of (poly)phenol consumption as part of a balanced diet, human studies are scarce and mechanistic insight is still lacking. In this regard, we make the case that dietary (poly)phenols should be further explored to establish their therapeutic efficacy on brain health through modulation of the gut–brain axis, with much greater emphasis on carefully designed human interventions.

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“…Intestinal bacteria can stimulate reactive oxygen species (ROS) production via intestinal epithelial cells, and notably, probiotics can induce antioxidant activity in these cells (Aviello and Knaus, 2018;Vona et al, 2021;Kunst et al, 2023). Extracts from Dendrobium nobile possess antioxidant properties that increase the activities of SOD, CAT, and GSH-Px in the skin, blood, liver, and brain, increase the F/B ratio in aging mice, enhance the abundance of probiotic bacteria Lactobacillus and Muribaculum, and reduce the presence of pathogenic bacteria like Staphylococcus, Corynebacterium, and Brevibacterium (Gao et al, 2022). Dihydrocurcumin regulates glucose intake, moderates SREBP-1C/PPAR-a/pAKT expression, and decreases levels of triglycerides, oxidative stress, and insulin resistance (Yu et al, 2018).…”

Section: Improving Oxidative Stressmentioning

confidence: 99%

Exploring global research status and trends in anti-obesity effects of traditional Chinese medicine through intestinal microbiota: a bibliometric study

Huang,

Wang,

Kuang

et al. 2023

Front. Cell. Infect. Microbiol.

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BackgroundThe intestinal microbiota (IM) has been found to contribute to metabolic disorders that lead to excessive fat accumulation, systemic and chronic low-grade inflammation, and insulin resistance in the host. Current research highlights a pivotal interaction between IM and traditional Chinese medicine (TCM) in mitigating obesity-related diseases. Undeniably, IM stands as a central focus in TCM research aimed at preventing and treating obesity. Therefore, tracing the progress and trends in this field can offer valuable references and insights for future studies.MethodsOn June 17, 2023, we conducted a literature search on the topic of “IM and obesity in TCM” spanning the period from 2009 to 2023. We extracted the primary information of the publications, which includes complete records and reference citations, from the Science Citation Index Expanded (SCI-E) within the Web of Science Core Collection (WoSCC). To visualize and analyze the literature, we utilized CiteSpace and VOSviewer for bibliometric analysis.ResultsDuring the past fifteen years, a rapid increase in the number of publications has been observed. The cooperative networks demonstrate China, Beijing University of Chinese Medicine, and Food & Function as the most active countries, organizations, and journals in this field, respectively. Liu Bin has contributed the most publications. A paper by Xu Jia, published in 2014, holds the highest Local Citation Score (LCS). Analyses of keyword co-occurrence and reference co-citation indicate that the research hotspots of IM and obesity in TCM are primarily focused on the metabolic benefits driven by endogenous functional metabolic molecules generated by TCM regulation of IM. Other focal points include the mechanism by which TCM regulates IM to restore the intestinal mucosal barrier This is a provisional file, not the final typeset article, and manages the gut-organ axis, the metabolic advantages of acupuncture’s regulation of IM, and the process by which Chinese medicine small molecules transform IM.ConclusionThis research offers a comprehensive understanding of the current status, hotspots, and trends in global TCM research. Additionally, it provides a comprehensive summary and exploration of the latest advancements in this field, thereby emphasizing the essence of TCM more effectively.

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Various Fractions of Alcoholic Extracts from Dendrobium nobile Functionalized Antioxidation and Antiaging in D-Galactose-Induced Aging Mice

Cited by 5 publications

References 39 publications

A Pectic Polysaccharide from Codonopsis pilosula Alleviates Inflammatory Response and Oxidative Stress of Aging Mice via Modulating Intestinal Microbiota-Related Gut–Liver Axis

A Pectic Polysaccharide from Codonopsis pilosula Alleviates Inflammatory Response and Oxidative Stress of Aging Mice via Modulating Intestinal Microbiota-Related Gut–Liver Axis

Dietary (Poly)phenols and the Gut–Brain Axis in Ageing

Exploring global research status and trends in anti-obesity effects of traditional Chinese medicine through intestinal microbiota: a bibliometric study

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