Various aspects of inflammation in heart failure

Dutka, Mieczysław; Bobiński, Rafał; Ulman-Włodarz, Izabela; Hajduga, M.; Bujok, Jan; Pająk, Celina; Ćwiertnia, Michał

doi:10.1007/s10741-019-09875-1

Cited by 49 publications

(41 citation statements)

References 105 publications

(172 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Growing evidence indicates that nonischemic myocardial injury is also associated with inflammation. It has been demonstrated that inflammatory factor production and inflammatory cell infiltration occurs in post-TAC in mice 53,54 . NLRP3 has been reported to participate in the regulation of inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload

et al. 2020

View full text Add to dashboard Cite

Chronic heart failure (CHF) is the final outcome of many cardiovascular diseases, and is a severe health issue faced by the elderly population. Mixed lineage kinase 3 (MLK3), a member of MAP3K family, is associated with aging, inflammation, oxidative stress, and related diseases, such as CHF. MLK3 has also been reported to play an important role in protecting against cardiomyocyte injury; however, its function in myocardial fibrosis is unknown. To investigate the role of MLK3 in myocardial fibrosis, we inhibited the expression of MLK3, and examined cardiac function and remodeling in TAC mice. In addition, we assessed the expression of MLK3 protein in ventricular cells and its downstream associated protein. We found that MLK3 mainly regulates NF-κB/NLRP3 signaling pathway-mediated inflammation and that pyroptosis causes myocardial fibrosis in the early stages of CHF. Similarly, MLK3 mainly regulates the JNK/p53 signaling pathway-mediated oxidative stress and that ferroptosis causes myocardial fibrosis in the advanced stages of CHF. We also found that promoting the expression of miR-351 can inhibit the expression of MLK3, and significantly improve cardiac function in mice subjected to TAC. These results suggest the pyroptosis and ferroptosis induced by MLK3 signaling in cardiomyocytes are essential for adverse myocardial fibrosis, in response to pressure overload. Furthermore, miR-351, which has a protective effect on ventricular remodeling in heart failure caused by pressure overload, may be a key target for the regulation of MLK3.

show abstract

Section: Discussionmentioning

confidence: 99%

Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Clinical studies established a correlation between circulating inflammatory cells and biomarkers of inflammation and the degree of left ventricular dysfunction in patients with HF [101]. Elevated plasma concentrations of such biomarkers as TNF-alpha, interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), galectin-3 or growth differentiation factor 15 (GDF15) are widely believed to be typical in HF [85,[101][102][103].…”

Section: The Anti-inflammatory and Antioxidant Effects Of Sglt2ismentioning

confidence: 99%

Sodium glucose cotransporter 2 inhibitors: mechanisms of action in heart failure

et al. 2020

Self Cite

View full text Add to dashboard Cite

Diabetes is a key independent risk factor in the development of heart failure (HF) and a strong, adverse prognostic factor in HF patients. HF remains the primary cause of hospitalisation for diabetics and, as previous studies have shown, when HF occurs in these patients, intensive glycaemic control does not directly improve the prognosis. Recent clinical studies assessing a new class of antidiabetic drugs, sodium-glucose cotransporter 2 inhibitors (SGLT2is) showed some unexpected beneficial results. Patients treated with SGLT2is had a significant decrease in both cardiovascular (CV) and all-cause mortality and less hospitalisations due to HF compared to those given a placebo. These significant clinical benefits occurred quickly after the drugs were administered and were not solely due to improved glycaemic control. These groundbreaking clinical trials’ results have already changed clinical practice in the management of patients with diabetes at high CV risk. These trials have triggered numerous experimental studies aimed at explaining the mechanisms of action of this unique group of drugs. This article presents the current state of knowledge about the mechanisms of action of SGLT2is developed for the treatment of diabetes and which, thanks to their cardioprotective effects, may, in the future, become a treatment for patients with HF.

show abstract

“…of immunosuppressive therapeutic opportunities. Biomarkers, identifying inflammatory processes in heart failure, are becoming recognized as indicator of inappropriate immune response and for potential therapeutic value (10).…”

Section: Biomarkers Of the Inflammatory/matrix Remodeling/fibrosis Axmentioning

confidence: 99%

The Diagnostic and Therapeutic Value of Multimarker Analysis in Heart Failure. An Approach to Biomarker-Targeted Therapy

Topf

Mirna

Ohnewein

et al. 2020

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Background: Heart failure is a pathophysiological state, which is still associated with high morbidity and mortality despite established therapies. Diverse well-known biomarkers fail to assess the variety of individual pathophysiology in the context of heart failure.Methods: An analysis of prospective, multimarker-specific therapeutic approaches to heart failure based on studies in current literature was performed. A total of 159 screened publications in the field of biomarkers in heart failure were hand-selected and found to be eligible for this study by a team of experts.Results: Established biomarkers of the inflammatory axis, matrix remodeling, fibrosis and oxidative stress axis, as well as potential therapeutic interventions were investigated. Interaction with end organs, such as cardio-hepatic, cardio-renal and cardio-gastrointestinal interactions show the complexity of the syndrome and could be of further therapeutic value. MicroRNAs are involved in a wide variety of physiologic and pathophysiologic processes in heart failure and could be useful in diagnostic as well as therapeutic setting.Conclusion: Based on our analysis by a biomarker-driven approach in heart failure therapy, patients could be treated more specifically in long term with a consideration of different aspects of heart failure. New studies evaluating a multimarker – based therapeutic approach could lead in a decrease in the morbidity and mortality of heart failure patients.

show abstract

Various aspects of inflammation in heart failure

Cited by 49 publications

References 105 publications

Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload

Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload

Sodium glucose cotransporter 2 inhibitors: mechanisms of action in heart failure

The Diagnostic and Therapeutic Value of Multimarker Analysis in Heart Failure. An Approach to Biomarker-Targeted Therapy

Contact Info

Product

Resources

About