Various approaches to modify biomaterial surfaces for improving hemocompatibility

Mao, Chun; Qiu, Yongzhi; Sang, Hai-Bo; Mei, Hua; Zhu, Aiping; Shen, Jian; Lin, Shiwei

doi:10.1016/j.cis.2004.02.001

Cited by 171 publications

(128 citation statements)

References 59 publications

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“…In this context, Mao et al described that positively charged surfaces seem to induce activation of platelets. On the other hand negatively charged surfaces, like intact intima, have a good blood compatibility [16]. Similar influence of plasma-chemical modifications was also described by Wulf et al for positively charged surfaces [2].…”

Section: Biocompatibilitysupporting

confidence: 52%

Surface functionalization of poly(ε-caprolactone) and poly(3-hydroxybutyrate) with VEGF

Teske¹,

Sternberg²

2017

BioNanoMaterials

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Abstract:In this study, surface modifications for the biodegradable polymers poly(ε-caprolactone) (PCL) and poly(3-hydroxybutyrate) [P(3HB)] were developed in order to improve their suitability as scaffold material for bioartificial vessel prostheses. The challenge of wet-chemical surface modifications is to avoid bulk adjustments resulting in undesired changes in mechanical properties of these polymers. Nevertheless subsequent immobilization and controlled release of potent angiogenic biomolecules like vascular endothelial growth factor (VEGF) from the polymer surface is required. In order to improve the biocompatibility of PCL and P(3HB), terminal hydroxyl groups on the surface of these polymers were generated via oxygen (O 2 ) and carbon dioxide (CO 2 ) plasma. Then, the immobilization of VEGF was achieved through hydrolysable ester bonds using the crosslinker N,N′-disuccinimidyl carbonate (DSC). Our studies demonstrated that the plasma surface activations have no negative influence on the viability of L929 mouse fibroblasts and hemocompatibility. The immobilization of VEGF on the modified polymers via DSC is improved compared to the untreated reference. For the CO 2 plasma-chemical activated surfaces we observed the highest VEGF surface immobilization. Our release studies also reveal the highest cumulative release using CO 2 plasma-chemical activated samples.

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Section: Biocompatibilitysupporting

confidence: 52%

Surface functionalization of poly(ε-caprolactone) and poly(3-hydroxybutyrate) with VEGF

Teske¹,

Sternberg²

2017

BioNanoMaterials

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“…As an outcome, a plethora of techniques including physical modifications, chemical modifications, and radiation have been developed to effectively modify material surface characteristics. [34][35][36][37] The modification of many material surface properties (including chemistry, wettability, domain composition and morphology) has been found to influence protein adsorption and subsequent cellular responses to biomaterials in vitro. Some studies have shown how surface chemistry and IgG and serum protein adsorption modulated monocytes and macrophage adhesion in vitro.…”

Section: Introductionmentioning

confidence: 99%

Species and Density of Implant Surface Chemistry Affect the Extent of Foreign Body Reactions

et al. 2008

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Implant-associated fibrotic capsule formation presents a major challenge for the development of long term drug release microspheres and implantable sensors. Since material properties have been shown to affect in vitro cellular responses and also to influence short term in vivo tissue responses, we have thus assumed that the type and density of surface chemical groups would affect the degree of tissue responses to microsphere implants. To test this hypothesis, polypropylene particles with different surface densities of -OH and -COOH groups, along with the polypropylene control (-CH 2 groups) were utilized. The influence of functional groups and their surface densities on tissue reactions were analyzed using a mice subcutaneous implantation model. Our comparative studies included determination and correlation of the extents of fibrotic capsule formation, cell infiltration into the particles and recruitment of CD11b+ inflammatory cells for all of the substrates employed. We have observed major differences among microspheres coated with different surface functionalities. Surfaces with -OH surface groups trigger the strongest responses while -COOH rich surfaces prompt the least tissue reactions. However, variation of the surface density of either functional group has a relatively minor influence on the extent of fibrotic tissue reactions. The present results show that surface functionality can be used as a powerful tool to alter implant-associated fibrotic reactions and, potentially, to improve the efficacy and function of drug delivery microspheres, implantable sensors and tissue engineering scaffolds.

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“…In addition, the film deposited on the polymer surface can be manipulated by changing the deposition rate, energy range and surface topography [97]. Plasma pre-treatment has also been used prior to attaching collagen to a polymer nanofiber mesh, a method that showed increased cell attachment, spreading and viability [98]. Thus, if a less corrosive method for biomolecule attachment is required, plasma treatment may be a favorable option, but great care must be taken to avoid contamination of the sample.…”

Section: Attachment Of Pharmaceuticals Biopharmaceuticals or Biomolementioning

confidence: 99%

A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices

Govindarajan

Shandas

2014

Polymers

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Abstract:The search for a single material with ideal surface properties and necessary mechanical properties is on-going, especially with regard to cardiovascular stent materials. Since the majority of stent problems arise from surface issues rather than bulk material deficiencies, surface optimization of a material that already contains the necessary bulk properties is an active area of research. Polymers can be surface-modified using a variety of methods to increase hemocompatibilty by reducing either late-stage restenosis or acute thrombogenicity, or both. These modification methods can be extended to shape memory polymers (SMPs), in an effort to make these materials more surface compatible, based on the application. This review focuses on the role of surface modification of materials, mainly polymers, to improve the hemocompatibility of stent materials; additional discussion of other materials commonly used in stents is also provided. Although shape memory polymers are not yet extensively used for stents, they offer numerous benefits that may make them good candidates for next-generation stents. Surface modification techniques discussed here include roughening, patterning, chemical modification, and surface modification for biomolecule and drug delivery.

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Various approaches to modify biomaterial surfaces for improving hemocompatibility

Cited by 171 publications

References 59 publications

Surface functionalization of poly(ε-caprolactone) and poly(3-hydroxybutyrate) with VEGF

Surface functionalization of poly(ε-caprolactone) and poly(3-hydroxybutyrate) with VEGF

Species and Density of Implant Surface Chemistry Affect the Extent of Foreign Body Reactions

A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices

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