Various approaches for accessing the influence of human leukocyte antigens disparity in haploidentical stem cell transplantation

Abstract

Introduction:We investigated the association of HLA on clinical outcomes in our cohort of patients in the haplo-HSCT program using the HLAMatchmaker (EM) and PIRCHE score (PS) algorithms. Methods:The group comprised 64 patients (male = 35-54.7%, female 29-45.3%; median age 43 years) and their related haplo-HSCT donors (male = 30-46.9%, female 34-53.1%). HLA-A/B/C/DRB1/DQB1/DPB1 loci were analyzed.Results: Multivariate analysis of the association between different HLA or patient/ donor-related parameters and clinical outcome revealed the following associations with statistical significance: GvHD and HLA class I PS in the GvH direction (p = .0420) and relapse with diagnosis (p = .0163). For OS, the only variable showing a tendency of association was the source of HSCT (p = .0965). Conclusion:Combined results of univariate and multivariate analysis suggest that the patients awaiting the selection of the best haplo-HSCT donor could benefit the most from the combination of all three approaches, in cases when a suitable donor can be chosen from a number of potential donors.

Hematopoietic stem cell transplantation in Zagreb: the first 40 years

“…Recent results with haploidentical transplant in acute leukemia are very encouraging, approaching those with related and unrelated matched donors (58)(59)(60)(61).…”