Variety of radiological findings in a family with COVID-19: a case report

Abstract

Introduction In December 2019, a case series of pneumonia associated with seafood and wet animal market was reported as coronavirus disease 2019 (COVID-19) in Wuhan, Hubei, China. The COVID-19 less frequently affects the pediatric group, and asymptomatic children are commonly reported. This feature is important due to the potential transmissibility of COVID-19 through these cases. There is a variety of atypical clinical symptoms and imaging manifestations among children infected with COVID-19. Case presentation We report two sisters with COVID-19 pneumonia who had close contact with their 77-year-old grandmother. Their grandmother expired with a confirmed diagnosis of COVID-19. The older sister (15 years old) firstly presented with severe cough, fever, dyspnea, diarrhea, and lymphopenia. A chest computed tomography (CT) scan showed atypical lobar pneumonic infiltration only in the left lower lobe. The younger sister (6 years old) was affected the following day with milder symptoms (i.e., fever and cough). Her chest CT scan demonstrated typical mild generalized patchy ground-glass opacity with interlobular septal thickening scattered in both lungs. The CT presentation of their grandmother showed typical bilateral white lungs with crazy paving appearance. The standard regimen for both sisters was administrated, and the patients’ respiratory conditions improved after 5 days of treatment. Both cases were discharged with good general conditions. Conclusion Children are considered potentially important causes of COVID-19 transmission. The symptoms in children are milder, and clinicians should be aware of taking a definite history of infected family members. Atypical clinical symptoms and imaging features are more common in children than adults; therefore, it is necessary to identify the typical and atypical imaging patterns of COVID-19 pneumonia in the pediatric population.

Child transmission of SARS-CoV-2: a systematic review and meta-analysis

“…Of the 40 articles included, 13 studies were conducted in the North America [ 13 – 25 ], 14 in Europe [ 4 , 10 , 26 – 37 ], 12 from Asia [ 38 – 49 ], and 1 from Australia [ 50 ]. Of the 40 articles, 23 identified household child-to-adult or child-to-child transmission [ 10 , 13 – 15 , 18 , 19 , 24 – 27 , 29 , 32 – 34 , 38 – 42 , 45 – 48 ]. Seventeen articles documented transmission at a school [ 4 , 17 – 23 , 28 – 30 , 35 – 37 , 43 , 44 , 50 ], 6 in a childcare setting, [ 19 , 28 , 29 , 31 , 49 , 50 ] and 5 from other social gatherings [ 16 , 17 , 23 , 24 , 47 ] (Table 1 ).…”

Computed tomography findings in 3,557 COVID-19 infected children: a systematic review

“…,38,40,59,79,89,91,93,94,96,99,101,107,108), and the rest of them studied only children. There were 14 case reports(37,44,45,54,55,57,58,63,85,87,95,97), 8 case series…”

“…), 5 were from Turkey(66,72,92,99,107), 7 were from Iran(43,69,71,95,97,104,106), 2 were from Italy(87,112), 2 were from Brazil (96,114), 1 was from Egypt (85), 1 was from the Latin America (108), 1 was from France (105), 2 was from the UAE (91,93), 1 was from Portugal(113) and the remained 55 studies were from China. All of them were published in 2020-21.Among the 81 studies, 14 investigated children and adults(36…”