Varied presentation of sinonasal phosphaturic mesenchymal tumour: report of a case series with follow-up

Kurien, Regi; Rupa, Vedantam; Thomas, Meera

doi:10.1007/s00405-019-05341-8

Cited by 12 publications

(21 citation statements)

References 17 publications

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“…More than 70 cases in the head/neck have been reported in addition to the cases reported from our institute, and only 10 cases among them were refractory. (4,11,12,(14)(15)(16) Although this rate is higher than ours, it is plausible that TIO tumors in the head/neck have a favorable outcome. It does not make sense to compare the delicate differences between our cases and those reported in various institutes because other cases are so scattered.…”

Section: Discussioncontrasting

confidence: 64%

“…Among each tumor location, head/neck tumors exerted the highest recovery rate, whereas spine tumors were most likely to be refractory. More than 70 cases in the head/neck have been reported in addition to the cases reported from our institute, and only 10 cases among them were refractory . Although this rate is higher than ours, it is plausible that TIO tumors in the head/neck have a favorable outcome.…”

Section: Discussioncontrasting

confidence: 53%

“…Approximately one-half of the tumors were located in the lower extremities either in the refractory group or in the recovery group. Tumors in the head/neck were less common (5/42, 11.9% versus 62/188, 33.0%, p < .001) whereas tumors in the spine were more common (7/42, 16 Tumors located in the spine showed a significantly higher refractory rate than those located in the head/neck, upper extremities and other sties (p < .001). Although the refractory rates of tumors located in the upper extremities and hip/pelvis seemed lower than those of the spine, there was no significant difference, probably because of the relatively small sample size.…”

Section: Different Distributions Of Tumors Between the Refractory Andmentioning

confidence: 95%

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Nonremission and Recurrent Tumor-Induced Osteomalacia: A Retrospective Study

Jiang

Huo

et al. 2019

Journal of Bone and Mineral Research

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Tumor‐induced osteomalacia (TIO) is a rare paraneoplastic syndrome. It is curable by excision of the causative tumor. However, a few cases may persist or relapse after tumor resection. We aimed to investigate the rate of these events and related factors. We retrospectively studied TIO patients treated with surgery in a tertiary hospital. TIO was established based on a pathologic examination or the reversion of hypophosphatemia. Refractory TIO patients consisted of those with nonremission or recurrent hypophosphatemia after surgery. A total of 230 patients were confirmed as having TIO. After primary surgery, 26 (11.3%) cases persisted, and 16 (7.0%) cases recurred. The overall refractory rate was 18.3%. The median time of recurrence was 33 months. Compared with patients in the recovery group, patients in the refractory group were more likely to be female (59.5% versus 41.0%, p = .029) and have a lower serum phosphate level (0.44 ± 0.13 versus 0.50 ± 0.11 mmol/L, p = .002). The refractory rate was lowest in head/neck tumors (7.5%) and highest in spine tumors (77.8%). Regarding the tissue involved of tumor location, the refractory rate was higher in tumors involving bone than tumors involving soft tissue (32.7% versus 7.0%, p < .001). The outcomes of malignant tumors were worse than those of benign tumors (p < .001): nonremission rate, 21.4% versus 9.7%; recurrence rate, 28.6% versus 6.5%. In the multivariate regression analysis, female sex, spine tumors, bone tissue‐involved tumors, malignancy, and low preoperation serum phosphorus levels were identified as risk factors for refractory outcomes. High preoperative fibroblast growth factor 23 (FGF23) levels were also associated with refractory after adjusting for involving tissue and tumor malignancy. In summary, we are the first to report the rate and clinical characteristics of refractory TIO in a large cohort. For patients with multiple risk factors, especially spine tumors, clinical practitioners should be aware of a poor surgical prognosis. © 2019 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.

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Section: Discussioncontrasting

confidence: 64%

Section: Discussioncontrasting

confidence: 53%

Section: Different Distributions Of Tumors Between the Refractory Andmentioning

confidence: 95%

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Nonremission and Recurrent Tumor-Induced Osteomalacia: A Retrospective Study

Jiang

Huo

et al. 2019

Journal of Bone and Mineral Research

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“…Nevertheless, these tumors occasionally exhibit features of malignancy and invade adjacent vital structures such as the skull base and orbits. 8 Most surrounding bony invasion can be well identified by imaging studies. 14 Two of the 10 patients in our study exhibited evidence of intracranial bony erosion and/or surrounding bony invasion on contrast-enhanced CT ( Figure 2H and Figure 3D , red arrow).…”

Section: Discussionmentioning

confidence: 99%

“…A previous study suggested that incomplete surgical resection combined with local radiotherapy is necessary for the remission of TIO-related symptoms if the tumor invades adjacent vital structures. 8 The patient in case 8 had previously received incomplete endoscopic resection combined with postoperative local radiotherapy at another institution, where postoperative histopathology suggested an SNHPC-like tumor. This patient did not achieve clinical remission and presented with local recurrence 2 years later ( Figure 2G , H , red arrow).…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment and Outcomes for Sinonasal and Skull Base Phosphaturic Mesenchymal Tumors

Tang

Mao

Lin

et al. 2020

Otolaryngol.--head neck surg.

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Objective To describe our clinical experience with surgical treatments for sinonasal phosphaturic mesenchymal tumors diagnosed at our institution. Study Design Retrospective case series. Setting Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University. Subjects and Methods We retrospectively reviewed the medical records of 10 patients diagnosed with phosphaturic mesenchymal tumors associated with tumor-induced osteomalacia between December 2014 and October 2019. Results There were 4 men and 6 women with a disease course of 1 to 19 years. All patients exhibited hypophosphatemia and tumor-induced osteomalacia. The tumor was located in the sinonasal region, frontal bone, and temporal bone in 8 patients, 1 patient, and 1 patient, respectively. Technetium-99m octreotide scintigraphy was used for tumor localization in 4 cases. Six patients underwent endoscopic resection; the remaining 4 underwent unilateral transorbital anterior and posterior ethmoid artery ligation + endoscopic resection, endoscopic resection + skull base repair, internal carotid artery stenting + transcatheter arterial embolization + temporal bone tumor excision + adipose tissue plugging, and endoscopic resection + transfrontal craniotomy (n = 1 each). Two patients had a history of incomplete endoscopic resection. All patients achieved clinical remission and normalized biochemical indices after surgery. Only 1 patient developed recurrence and died of a brain hernia. Conclusions A diagnosis of sinonasal phosphaturic mesenchymal tumors should be based on a combination of clinical, imaging, and pathological findings. Technetium-99m octreotide scintigraphy helps in locating the tumor. Complete surgical excision guarantees clinical remission, and preoperative transcatheter arterial embolization or feeding artery ligation may reduce intraoperative bleeding in cases of highly vascularized tumors.

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International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Kuan

Wang

Adappa

et al. 2024

Int Forum Allergy Rhinol

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BackgroundSinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represents a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology‐based topics spanning the field.MethodsIn accordance with prior ICAR documents, ICSNT assigned each topic as an Evidence‐Based Review with Recommendations, Evidence‐Based Review, and Literature Review based on level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses format, and completed sections underwent a thorough and iterative consensus‐building process. The final document underwent rigorous synthesis and review prior to publication.ResultsThe ICNST document consists of 4 major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology‐based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention.ConclusionAs an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses.This article is protected by copyright. All rights reserved

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Varied presentation of sinonasal phosphaturic mesenchymal tumour: report of a case series with follow-up

Cited by 12 publications

References 17 publications

Nonremission and Recurrent Tumor-Induced Osteomalacia: A Retrospective Study

Nonremission and Recurrent Tumor-Induced Osteomalacia: A Retrospective Study

Surgical Treatment and Outcomes for Sinonasal and Skull Base Phosphaturic Mesenchymal Tumors

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

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