Varicose veins: on the verge of discovering the cause?

Золотухин, И. А.; Анатольевич, Золотухин Игорь; Porembskaya, O.Ya.; Ярославна, Порембская Ольга; Сметанина, М. А.; Александровна, Сметанина Мария; Сажин, А В; Вячеславович, Сажин Александр; Филипенко, М. Л.; Леонидович, Филипенко Максим; Кириенко, А. И.; Иванович, Кириенко Александр

doi:10.15690/vramn1213

Cited by 6 publications

(3 citation statements)

References 53 publications

(72 reference statements)

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“…Anti-hypertensive effects of diosmin (namely, compromised NO-synthase inhibitor induced cardiac infarcts, hyaline arteriopathy and fibrinoid necrosis), presumably because of its activity in elimination of superoxide anions, were demonstrated in a rat model [43] . Peripheral arterial disease may also be treated with Sulodexide, which prevents cardiovascular events after myocardial infarction and exerts the relief of intermittent claudication [44] .…”

Section: Where Are We Now In Terms Of Learning In Terms Of Understanding and Where Are We Going? A Challenge For The Futurementioning

confidence: 99%

The genetic constituent of varicose vein pathogenesis as a key for future treatment option development

Сметанина¹,

Шевела²,

Gavrilov³

et al. 2021

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This perspective focuses primarily on the fundamental part of phlebology, where most attention is paid to the genetic aspects of the pathogenesis of varicose vein disease and where the main breakthrough advances in this area of research are discussed. We propose a direction for further actions to replenish molecular genetic knowledge about the main drivers of pathological processes in varicose vein disease and to complete the creation of an entire picture of pathogenesis, which, in turn, may serve as a key for the development of treatment options in the future in order to translate research evidence into clinical practice.

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Section: Where Are We Now In Terms Of Learning In Terms Of Understanding and Where Are We Going? A Challenge For The Futurementioning

confidence: 99%

The genetic constituent of varicose vein pathogenesis as a key for future treatment option development

Сметанина¹,

Шевела²,

Gavrilov³

et al. 2021

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“…Given the lack of knowledge about the sDC-SIGN function, it is currently challenging to propose a mechanism for its involvement in VVs. However, since the inflammatory response is activated in VVs and is considered part of their pathogenesis [5][6][7][8]46,47], we can speculate that this potential link is related to inflammation.…”

Section: Discussionmentioning

confidence: 98%

Mendelian randomization analysis of plasma levels of CD209 and MICB proteins and the risk of varicose veins of lower extremities

et al. 2022

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Varicose veins of lower extremities (VVs) are a highly prevalent condition, the pathogenesis of which is still not fully elucidated. Mendelian randomization (MR) can provide useful preliminary information on the traits that are potentially causally related to the disease. The aim of the present study is to replicate the effects of the plasma levels of MHC class I polypeptide-related sequence B (MICB) and cluster of differentiation 209 (CD209) proteins reported in a previous hypothesis-free MR study. We conducted MR analysis using a fixed effects inverse-variance weighted meta-analysis of Wald ratios method. For MICB and CD209, we used data from a large-scale genome-wide association study (GWAS) for plasma protein levels (N = 3,301). For VVs, we used GWAS data obtained in the FinnGen project (N = 128,698), the eMERGE network (phase 3, N = 48,429), and the UK Biobank data available in the Gene ATLAS (N = 452,264). The data used in the study were obtained in individuals of European descent. The results for MICB did not pass criteria for statistical significance and replication. The results for CD209 passed all statistical significance thresholds, indicating that the genetically predicted increase in CD209 level is associated with increased risk of VVs (βMR (SE) = 0.07 (0.01), OR (95% CI) = 1.08 (1.05–1.10), P-value = 5.9 ×10−11 in the meta-analysis of three cohorts). Our findings provide further support that CD209 can potentially be involved in VVs. In future studies, independent validation of our results using data from more powerful GWASs for CD209 measured by different methods would be beneficial.

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“…A total of 80 participants, 40 with varicose veins and 40 without varicose veins were included in the study.Respondents who have been classified into case groups who have varicose veins and controls who do not will be searched for risk factors such as high BMI, prolonged standing, smoking habits, and family history of varicose veins using questionnaires. 7 The collected data will be processed using the Statistical Package for the Social Sciences (SPSS) for Windows ver.26.0 program. The data distribution from both groups will be analyzed for correlation with risk factors using chi-square analysis.…”

Section: Methodsmentioning

confidence: 99%

Risk Factors of Varicose Vein in Blue-Collared Workers of Glodok Makmur Shopping Centre Jakarta

Chandra,

Wardana,

Widianti

et al. 2024

eum

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Varicose veins, apart from affecting daily activities such as walking, also impact aesthetics. Varicose veins are dilated veins characterized by the bulging of blood vessels. In Europe, varicose veins are experienced by 50% of the population, while in Indonesia, it is around 25-30% of the population. Although varicose veins have a low mortality rate, the discomfort, swelling, and hyperpigmentation they cause can progress to more complex health problems. This study aims to determine the risk factors for lower limbs varicose veins in blue-collar workers at the Glodok Makmur shopping centre Jakarta. A case-control design was used in this research. A total of 40 cases, namely male workers with lower limb varicose veins, and 40 controls, namely male workers without lower leg varicose veins, were selected using purposive sampling. Data from respondents were collected through questionnaires and analyzed using the Chi Square test with a significance of ? = 0.05. From the results of the analysis, it was found that lower limbs varicose veins had a significant relationship with high BMI (OR = 4.667, 95% CI = 1.507-14.455), dominant working position standing (OR = 7.071, 95% CI = 2.519-19.850), smoking habits (OR = 0.648, 95% CI = 0.503-3.018), and family history of varicose veins (OR = 6.000, 95% CI = 2.207-16.313). The results of this study indicate that high BMI, dominant working position standing, smoking habit, and family history of varicose veins are potential risk factors for the occurrence of lower leg varicose veins in blue-collar workers at the Glodok Makmur shopping centre Jakarta.

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Varicose veins: on the verge of discovering the cause?

Cited by 6 publications

References 53 publications

The genetic constituent of varicose vein pathogenesis as a key for future treatment option development

The genetic constituent of varicose vein pathogenesis as a key for future treatment option development

Mendelian randomization analysis of plasma levels of CD209 and MICB proteins and the risk of varicose veins of lower extremities

Risk Factors of Varicose Vein in Blue-Collared Workers of Glodok Makmur Shopping Centre Jakarta

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