Varicose veins in primary care

Atkins, Eleanor; Mughal, Nadeem A.; Place, Fiona; Coughlin, Patrick A.

doi:10.1136/bmj.m2509

Cited by 9 publications

(7 citation statements)

References 23 publications

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“…Varicocele is one of the common causes of male infertility, referring to the elongation and tortuosity of vine venous plexus in the spermatic cord [ 1 – 2 ]. The disease is more often seen in teenagers; according to the survey, the incidence of the disease is high, accounting for 10%~15% of normal men; clinical manifestations of scrotal swelling, local intermittent swelling pain, and other symptoms, if not timely treatment, may cause vague pain, dull pain, and another discomfort, leading to male testicular function decline, seriously affecting the daily life of patients [ 3 – 4 ]. Clinical drug treatment, such as flavonoids, and ockeyesin treatment can reduce clinical symptoms and improve sperm activity, but for patients with poor drug treatment effects, surgical treatment can be selected, which can restore the fertility of patients [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

The Application Effect of Jiawei Sanyu Shengjing Decoction Combined with High Ligation of the Spermatic Vein in Varicocele Male Infertility Patients

Han

Zhang

et al. 2022

Applied Bionics and Biomechanics

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Objective. To analyze the application effect of Jiawei Sanyu Shengjing decoction combined with high ligation of the internal spermatic vein in male infertility patients with varicocele (VC). Methods. 106 male infertility patients with VC treated in our hospital from December 2018 to March 2019 were selected as examples. According to the length of stay, they were divided into the control group and observation group, with 53 cases in each group. High ligation of the internal spermatic vein was performed in both groups. On this basis, the observation group was treated with modified Sanyu Shengjing decoction, and the therapeutic effects of the two groups were compared. Results. The effective rate of 94.34% in the observation group was higher than 79.25% in the control group ( P < 0.05 ). After treatment, the serum index level and sperm deformity rate in the observation group were lower than those in the control group, and the semen density and sperm activity were higher than those in the control group ( P < 0.05 ). Conclusion. The treatment of VC male infertility with modified Sanyu Shengjing decoction combined with high ligation of the internal spermatic vein can effectively improve the number of sperm and reduce the density of semen.

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Section: Introductionmentioning

confidence: 99%

The Application Effect of Jiawei Sanyu Shengjing Decoction Combined with High Ligation of the Spermatic Vein in Varicocele Male Infertility Patients

Han

Zhang

et al. 2022

Applied Bionics and Biomechanics

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“…The development of varicose veins during pregnancy is related to external compression of the pelvic veins by the developing fetus, as well as pregnancy-related hormones and changes that affect the smooth muscle cells of the veins, resulting in dilation. Although, in most cases, they improve after pregnancy, approximately 82% of these women may later develop varicosities [32]. Spider angiomas, on the other hand, are more frequently observed in regions of the skin drained by the superior vena cava, neck, throat, face (around the eyes), upper chest, arms and hands.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Physiological Skin Changes in Pregnancy in a Public Maternity in Southern Brazil

Nunes¹,

Ribeiro²,

Gabriela³

et al. 2022

J Dermatol Res Ther

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Objective:To analyze the characteristics of physiological dermatological changes during pregnancy.Methods: This is a descriptive study, carried out in a public maternity hospital in southern Brazil, from June to August 2021 through a randomized sample of puerperal women. Through a self-reported interview, maternal-fetal data, sun exposure, photoprotection and skin changes were analyzed. Results: A total of 439 postpartum women were evaluated, 415 (94.5%) of whom presented some dermatological alteration. 237 (54.0) felt uncomfortable, affecting the selfesteem of 182 (41.5) and social interaction of 82 (18.7). However, only 64 (14.5) received medical advice and only 62 (14.1) underwent treatment. Hyperpigmentation affected 345 patients (78.6), starting mainly in the 2 nd trimester. The most affected regions were linea alba (68.7), nipples (77.4) and axillae (57.7). Melasma affected 144 women (32.8), and the 2 nd trimester was also the most prevalent. Of these, 92 (63.9) had Centrofacial Melasma, 19 (13.2) Peripheral and 33 (22.9) Mixed. Stretch marks occurred in 253 postpartum women (57.6), starting in the 3 rd trimester. The main regions affected were the abdomen (77.9), hips (49.8) and breasts (28.0). Vascular changes occurred in 123 patients (28.0), starting in the 3 rd trimester. The most common presentations were varicosities (86.2) and vascular spiders (22.8). Erythema Palmar affected 77 women (17.5), with onset prevalent in the 2 nd trimester. Conclusion:94.5% of the patients had some dermatological alteration, with Hyperpigmentation (78.6) and Stretch Marks (57.6) being the most prevalent.

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“…VV denotes vein tortuosity and expansion due to venous factors and blood-related issues ( Atkins et al, 2020 ; Bohler, 2023 ). Comparison of VV pathological tissues with normal surrounding tissues unveiled upregulation of tRF-36-F900BY4D-84KRIME and tRF-23-87R8WP9IY, alongside downregulation of tRF-40-86J8WPMN1E8Y7Z2R.…”

Section: Exploring Mapk-related Tsrnas In Disease: Identification Exp...mentioning

confidence: 99%

Unveiling the role of tRNA-derived small RNAs in MAPK signaling pathway: implications for cancer and beyond

Wang,

Huang,

Ying

et al. 2024

Front. Genet.

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tRNA-derived small RNAs (tsRNAs) are novel small non-coding RNAs originating from mature or precursor tRNAs (pre-tRNA), typically spanning 14 to 30 nt. The Mitogen-activated protein kinases (MAPK) pathway orchestrates cellular responses, influencing proliferation, differentiation, apoptosis, and transformation. tsRNAs influence the expression of the MAPK signaling pathway by targeting specific proteins within the pathway. Presently, four MAPK-linked tsRNAs have implications in gastric cancer (GC) and high-grade serous ovarian cancer (HGSOC). Notably, tRF-Glu-TTC-027 and tRF-Val-CAC-016 modulate MAPK-related protein expression, encompassing p38, Myc, ERK, CyclinD1, CyclinB, and c-Myc, hindering GC progression via MAPK pathway inhibition. Moreover, tRF-24-V29K9UV3IU and tRF-03357 remain unexplored in specific mechanisms. KEGG analysis posits varied tsRNAs in MAPK pathway modulation for diverse non-cancer maladies. Notably, high tRF-36-F900BY4D84KRIME and tRF-23-87R8WP9IY expression relates to varicose vein (VV) risk. Elevated tiRNA-Gly-GCC-001, tRF-Gly-GCC-012, tRF-Gly-GCC-013, and tRF-Gly-GCC-016 target spinal cord injury (SCI)-related brain-derived neurotrophic factor (BDNF), influencing MAPK expression. tRF-Gly-CCC-039 associates with diabetes foot sustained healing, while tRF-5014a inhibits autophagy-linked ATG5 in diabetic cardiomyopathy (DCM). Additionally, tsRNA-14783 influences keloid formation by regulating M2 macrophage polarization. Upregulation of tRF-Arg-ACG-007 and downregulation of tRF-Ser-GCT-008 are associated with diabetes. tsRNA-04002 alleviates Intervertebral disk degeneration (IDD) by targeting PRKCA. tsRNA-21109 alleviates Systemic lupus erythematosus (SLE) by inhibiting macrophage M1 polarization. The upregulated tiNA-Gly-GCC-002 and the downregulated tRF-Ala-AGC-010, tRF-Gln-CTG-005 and tRF-Leu-AAG-001 may be involved in the pathogenesis of Lupus nephritis (LN) by affecting the expression of MAPK pathway. Downregulation of tsRNA-1018, tsRNA-3045b, tsRNA-5021a and tsRNA-1020 affected the expression of MAPK pathway, thereby improving Acute lung injury (ALI). This review comprehensively dissects tsRNA roles in MAPK signaling across cancers and other diseases, illuminating a novel avenue for translational medical exploration.

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Varicose veins in primary care

Cited by 9 publications

References 23 publications

The Application Effect of Jiawei Sanyu Shengjing Decoction Combined with High Ligation of the Spermatic Vein in Varicocele Male Infertility Patients

The Application Effect of Jiawei Sanyu Shengjing Decoction Combined with High Ligation of the Spermatic Vein in Varicocele Male Infertility Patients

Characteristics of Physiological Skin Changes in Pregnancy in a Public Maternity in Southern Brazil

Unveiling the role of tRNA-derived small RNAs in MAPK signaling pathway: implications for cancer and beyond

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