Varicella-like Infection Due to Herpes Simplex

Infecciones en pacientes reumatológicos asociadas a corticosteroides y antagonistas del factor de necrosis tumoral α

“…Las infecciones por virus herpes simplex pueden generar cuadros de glositis o ulceraciones perianales recurrentes, hepatitis aguda o infecciones crónicas cutá-neas en pacientes bajo terapia con glucocorticoides 6,[26][27][28] . En ocasiones, formas diseminadas de infección por virus herpes simplex pueden simular un cuadro de varicela en pacientes con corticosteroides.…”

Dermatologic Problems in the Intensive Care Unit: Part I

“…fection is most common in children and young adults [145,149]. Lesions begin as crops of 2 to 5 mm umbilicated vesicles or pustules on an erythematous base, appearing over 3 to 7 days.…”

“…Lesions begin as crops of 2 to 5 mm umbilicated vesicles or pustules on an erythematous base, appearing over 3 to 7 days. The usual sites involved are the head, neck, and upper trunk, and sometimes the extremities [145,149]. Affected areas may be painful or pruritic with prominent edema and regional lymphadenopathy.…”

“…Primary infections with herpes simplex virus are usually asymptomatic or manifested as gingivostomatitis or vulvovaginitis; recrudescence of the virus commonly occurs at one site producing a small number of rapidly healing grouped vesicles. In two principal settings, however, either primary or recurrent infection with herpes simplex virus can produce large numbers of scattered cutaneous lesions: (1) with certain underlying skin disorders, especially atopic dermatitis (where the infection is known as eczema herpeticum or Kaposi's varicelliform eruption; Fig 7), and (2) with immunosuppression, especially with lymphoreticular malignancies (Fig 8, Table 5) [141][142][143][144][145][146][147][148][149]. Either Type 1 or Type 2 Herpesl'Írus hominis may be responsible [149], and similar eruptions can also result from vaccinia [ 148,150] or Coxsackie A16 [151].…”

“…The ex-. act nature of the immunologic problem that allows dissemination has not been defined [145,152]. Although herpetic lesions may localize to areas of active dermatitis in patients suffering from atopic dermatitis [152], cutaneous dissemination can occur both in these patients [150] and in those suffering from Darier's disease [148] when the skin appears to be normal.…”