Variations of disseminated choroid plexus papilloma: 2 case reports and a review of the literature

McCall, Todd D.; Binning, Mandy J.; Blumenthal, Deborah T.; Jensen, Randy L.

doi:10.1016/j.surneu.2005.09.023

Cited by 40 publications

(39 citation statements)

References 26 publications

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“…Multifocal CPPs are also extremely rare. They may be a result of dissemination along the CSF pathways by an intraventricular tumor (17,18). In one of our cases, although the tumor in the foramen of Luschka was extremely small, early dissemination to the cisterna magna and spinal subarachnoid space had occurred.…”

Section: Discussionmentioning

confidence: 60%

Imaging findings of extraventricular choroid plexus papillomas: A study of 10 cases

Shi

Chen

et al. 2016

Oncology Letters

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Abstract. Extraventricular choroid plexus papillomas (CPPs) are rare. In this study, we reveal the imaging findings of CPPs located in extraventricular sites. The imaging findings of 11 masses [10 masses on magnetic resonance imaging (MRI) and one mass on computed tomography (CT)] of extraventricular CPP in 10 patients were retrospectively observed. The mass site, size, contour, signal intensity, cystic or solid appearance, calcification, capsules, degree and pattern of enhancement, and hydrocephalus were evaluated based on CT or MRI. The misdiagnosis rate of CPPs in extraventricular sites was 80.0% (8/10). Solitary masses and multiple masses were observed in nine patients (90.0%, 9/10) and one patient (10%, 1/10), respectively. In addition to the typical imaging findings [a lobulated, cauliflower-like or mulberry-like mass that is homogeneous isointense or slightly hypointense on T1-weighted imaging (T1WI) and heterogeneous isointense or slightly hyperintense on T2WI], four masses had round or oval contours and three had cystic components; abnormal signal intensity (mixed hyperintense signals on T1WI and T2WI or slightly hyperintense signals on T1WI or hypo-/hyperintense on T2WI) and low or no enhancements were observed in three and six masses, respectively; absence of hydrocephalus and mild or local hydrocephalus were each observed in four subjects, respectively. Hemorrhage and psammomatous bodies and/or calcification were observed in four and three masses, respectively. In conclusion, in addition to the typical imaging findings, atypical imaging findings, including atypical contours, abnormal signal intensity, low enhancement and absence of hydrocephalus were also observed in extraventricular CPPs.

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Section: Discussionmentioning

confidence: 60%

Imaging findings of extraventricular choroid plexus papillomas: A study of 10 cases

Shi

Chen

et al. 2016

Oncology Letters

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“…Metastasis is more frequent in CPC and a significant factor affecting the survival time in CPT [1,23]. Dissemination is also detected postoperatively, as in the present case [7,18,27,28]. Because spine MR imaging was not performed before the initial surgery, it remains unclear whether surgery was responsible for tumor cell seeding, which is described as drop metastasis.…”

Section: Discussionmentioning

confidence: 81%

“…Although meta-analysis of CPC demonstrated that etoposide was the most effective drug, the response rate was only less than half of cases [33]. Several reports demonstrated efficacy of temozolomide for CPTs (Table 1) [7,12]. In two cases of recurrent CPP with craniospinal dissemination treated with temozolomide, one case showed radiographically stable disease for 17 months after surgery, whereas in the other case tumor control failed [7].…”

Section: Discussionmentioning

confidence: 99%

“…Choroid plexus carcinoma (CPC), which shows histological malignancy, represents between 8% and 25% of all CPTs [2,3,[6][7][8]. The outcome of benign choroid plexus papilloma (CPP) is usually excellent following gross total resection, whereas the more aggressive biological behavior of CPC necessitates postoperative adjuvant treatment [1,9].…”

Section: Introductionmentioning

confidence: 99%

“…Chemotherapy has led to remission of choroid plexus carcinoma but does not always improve survival or avert recurrence [1,[10][11][12]. The DNA-alkylating agent temozolomide is effective for malignant gliomas, whereas evidence for its efficacy for CPT remains unclear [7,[12][13][14]. Promoter methylation of the O 6 -methylguanine-DNA methyltransferase (MGMT) DNA-repair gene is a marker for the response to alkylating agents in malignant gliomas, although this has not been probed in CPT [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

MGMT promoter methylation and temozolomide response in choroid plexus carcinoma

et al. 2011

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Choroid plexus carcinoma (CPC) is a malignant tumor with a strong tendency to spread along the cerebrospinal fluid pathway. There is no standardized chemotherapy protocol for this rare tumor. We report a 38-year-old man with CPC in the lateral ventricle with obstructive hydrocephalus. Because of the poor demarcation between thalamus and fornix, subtotal tumor resection was performed. Postoperative spine magnetic resonance (MR) image revealed whole spinal axis dissemination. After diagnosis of CPC, the patient was treated with whole ventricular and spine radiation concomitant with temozolomide chemotherapy, although the O 6 -methylguanine-DNA methyltransferase (MGMT) promoter was found to be unmethylated. Although MR images revealed transient stable disease during adjuvant therapy, tumor progression was depicted after four cycles of temozolomide therapy. We discuss the ineffectiveness of adjuvant temozolomide therapy for CPC in connection with O 6 -methylguanine-DNA methyltransferase promoter methylation.

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Management of disseminated choroid plexus papilloma: A case study

Zachary

George

Jaishri

et al. 2013

Pediatr Blood Cancer

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Choroid plexus papilloma (CPP) is a low-grade neoplasm of the choroid plexus that typically occurs in childhood and comprises under 1% of adult brain tumors. In this article, we report our experience delivering craniospinal irradiation (CSI) to a highly unusual case of disseminated CPP in an adult patient 8 years after an initial near total resection. The patient remains free of disease progression 3 years after completing radiation.

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Variations of disseminated choroid plexus papilloma: 2 case reports and a review of the literature

Cited by 40 publications

References 26 publications

Imaging findings of extraventricular choroid plexus papillomas: A study of 10 cases

Imaging findings of extraventricular choroid plexus papillomas: A study of 10 cases

MGMT promoter methylation and temozolomide response in choroid plexus carcinoma

Management of disseminated choroid plexus papilloma: A case study

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