Variations in tissue electropotentials and their possible significance

Schauble, Muriel K.; Gullick, Herbert D.; Habal, Mutaz B.

doi:10.1016/0022-4804(72)90114-x

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…The cell death observed in tumour treated with LIDC is caused by apoptosis and/or necrosis induced on that disease [45,46]. The subject has been tried to be explained by different anticancer mechanisms of LIDC, such as: induction of bioelectric forces in the tumour [16,19]; changes in bioelectric potential [47]; modifications of pH and temperature in the tumour [48,49]; changes in transmembrane potential of tumour cells [50,51]; ionization of tumour tissue [52]; production of toxic substances from the electrochemical reactions [22]; deposition of electrode material into tumour [53]; stimulation of immune system [54]; extraction of water tissue by electroosmosis [22,49]; and electrochemical reactions mainly referred to those involving reactive oxygen species. These possible anticancer mechanisms of LIDC are proposed from different experimental conditions established by each author.…”

Section: Introduction *mentioning

confidence: 99%

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Electrotherapy, a recent mode for anticancer treatment

Sequeira

Cardoso

2014

Ciência & Tecnologia dos Materiais

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Section: Introduction *mentioning

confidence: 99%

“…In the decade of 60-70, Schauble proposed the first scientific and technological fundamentals of electrotherapy in cancer [19]. In 1978, Nordenström applies for the first time electrotherapy in patients with lung cancer [20].…”

Section: Introduction *mentioning

confidence: 99%

Electrotherapy, a recent mode for anticancer treatment

Sequeira

Cardoso

2014

Ciência & Tecnologia dos Materiais

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Surface charge in foreign body carcinogenesis

Andrews

Todd

Kukulinsky

1979

J. Biomed. Mater. Res.

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The importance of surface charge in foreign body carcinogenesis was evaluated by implanting in C3H/HeJ male mice, bipolar polystyrene thermoelectrets formed in variously charged electrical fields. Charged electrets had tumor rates similar to control groups. The cumulative probability of tumor development was highest in the charged electret group being 0.58 at 133 weeks after implantation. The tumor rate for all charged electrets was 27% as compared to 17% and 6% for the control groups. The latent period of tumor induction varied little between groups and averaged approximately 700 days. No conclusions regarding the tumorigenic effect of electropositive versus electronegative sides of the electret were made although the majority of tumors arose on the electronegative (body) side of the electrets. An occasional tumor (2/25) arose on both sides of a single electret. The antigenicities of tumors tested by excise and challenge techniques were weak. The immunologic relationship between top and bottom growing tumors on a single electret could not be adequately determined because of the weak antigenicity.

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Effect of applied dc currents on experimental tumor growth in rats

Habal

1980

J. Biomed. Mater. Res.

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Morris Hepatoma experimental tumor in ACI rats is treated with small anodal direct current via an implantable power pack unit. There was major retardation in tumor growth when the treatment was started early. There was enhancement of tumor growth when the treatment was started early and then was discontinued. There was no statistical difference in growth control of the experimental tumor when the electrotherapy was given after the half-life of the tumor was achieved. This last point will be the most important to the clinician scientist, for it simulates the clinical situation that faces the treating physician.

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Variations in tissue electropotentials and their possible significance

Cited by 5 publications

References 6 publications

Electrotherapy, a recent mode for anticancer treatment

Electrotherapy, a recent mode for anticancer treatment

Surface charge in foreign body carcinogenesis

Effect of applied dc currents on experimental tumor growth in rats

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