Variations in the response of interleukins in neurosurgical intensive care patients monitored using intracerebral microdialysis

Hillman, Jan; Åneman, Oscar; Persson, Mikael; Andersson, Chris; Dabrosin, Charlotte; Mellergård, Pekka

doi:10.3171/jns.2007.106.5.820

Cited by 71 publications

(52 citation statements)

References 16 publications

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“…Cerebral microdialysis provides information on the metabolic state of the injured brain and allows determination of a variety of markers for immunocompetence in the cerebral extracellular fluid together with markers for metabolic derangement [12]. This is of relevance since both the blood-brain and blood-CSF barriers may be variably disrupted following aSAH, rendering blood and CSF levels of such markers less reliable [13].…”

Section: Introductionmentioning

confidence: 99%

Relevance of Cerebral Interleukin-6 After Aneurysmal Subarachnoid Hemorrhage

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Relevance of Cerebral Interleukin-6 After Aneurysmal Subarachnoid Hemorrhage

et al. 2010

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“…29,30 In this context, the particularity of the present study is the unique spectrum of immune markers and functional tests performed. aSAH is a heterogeneous disease and WFNS grade was high in symptomatic patients, which limits generalizability of the results.…”

Section: Limitations and Perspectivesmentioning

confidence: 99%

Immunodepression After Aneurysmal Subarachnoid Hemorrhage

Sarrafzadeh

Schlenk

Meisel

et al. 2011

Stroke

124

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Background and Purpose-Immunodepression after stroke is associated with complications like high infection rate, but its role in aneurysmal subarachnoid hemorrhage (aSAH) is unclear. This pilot study aimed to assess the presence of immunodepression and its association with infections after aSAH. Methods-Sixteen aSAH patients were enrolled in a prospective study on immune function in a single institution. Detailed immune monitoring (peripheral blood leukocyte subsets, monocyte human leukocyte antigen-DR expression, ex vivo lipopolysaccharide-induced monocytic, Concanavalin A-induced lymphocytic cytokine secretion) was performed until day 10 after aSAH. Occurrence of infection was assessed within 14 days after aSAH. Results-Sixteen consecutive aSAH patients (53.1Ϯ10.2 years; meanϮSD) met the inclusion criteria, classified as asymptomatic (World Federation of Neurological Surgeons; median, 1; quartile, 1-1; nϭ7) and symptomatic (median, 4; quartile, 3-5; nϭ9), all presenting with acute neurological deficits, and 5 of these had additional delayed cerebral ischemia. T-lymphopenia, impaired ex vivo lymphocytic/monocytic cytokine secretion, and decreased monocyte human leukocyte antigen-DR expression occurred over all World Federation of Neurological Surgeons grades but persisted beyond day 3 only in symptomatic patients. Pneumonia (67%; Pϭ0.011) was more frequent in symptomatic patients. Already at day 1, patients with pneumonia showed significantly lower T-cell counts and mitogen-induced interferon-␥ production compared to patients without infections. Conclusions-A pronounced SAH-induced immunodepression was observed early after aSAH but persisted only in symptomatic patients. Immunodepression was associated with a high incidence of pneumonia. Early diagnosis of immunodepression might allow targeted treatment to prevent infectious complications after aSAH. (Stroke. 2011;42:53-58.)

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“…The method uses a catheter, mimicking a blood capillary, which can be inserted into a variety of tissues. Cerebral microdialysis is used for bedside monitoring in neuro-intensive care [2] as well as a research tool within areas such as drug delivery and neuro-oncology [3].…”

Section: Introductionmentioning

confidence: 99%