Variations in the Light-induced Suppression of Nocturnal Melatonin with Special Reference to Variations in the Pupillary Light Reflex in Humans

Yasukouchi, Akira; Hazama, Tadaaki; Kozaki, Tomoaki

doi:10.2114/jpa2.26.113

Cited by 16 publications

(10 citation statements)

References 32 publications

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“…In a previous study by Yasukouchi et al, there was no linear relationship between the PLR and melatonin suppression levels (in response to different light intensities, ranging from 1-30 lux for the PLR, and from 30-600 lux for melatonin suppression). 35 We also did not find any significant association between baseline dim light pupil size and salivary melatonin concentrations.…”

Section: Discussioncontrasting

confidence: 57%

“…32 These and other studies lend support to the notion that there is a circadian modulation of the sensitivity of the nonvisual light photoreception system to light as already has been shown for the visual photoreceptive system. [33][34][35] Given that melanopsin is the primary circadian photoreceptor, we hypothesize that the intrinsic melanopsin-mediated pupil response may show a 24-hour variation that is influenced by the circadian clock and, therefore, will persist under constant dim lighting conditions. In our study, we addressed the question of whether the PLR varies with time of day.…”

mentioning

confidence: 99%

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Circadian and Wake-Dependent Effects on the Pupil Light Reflex in Response to Narrow-Bandwidth Light Pulses

Münch

Léon

Crippa

et al. 2012

Invest. Ophthalmol. Vis. Sci.

109

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Section: Discussioncontrasting

confidence: 57%

mentioning

confidence: 99%

Circadian and Wake-Dependent Effects on the Pupil Light Reflex in Response to Narrow-Bandwidth Light Pulses

Münch

Léon

Crippa

et al. 2012

Invest. Ophthalmol. Vis. Sci.

109

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“…The second is that the high potential of melatonin synthesis based on the high serotonin synthesis in the pineal during daytime might be available due to the night exposure to the “low temperature light” emitted from incandescent bulbs. Although many reports have shown that melatonin secretion is suppressed by light emitted from fluorescent lamps including short wave length (with around 460 nm of wave length) components [25-27], and especially short wave length light [27-30], this study newly implies that the combined behaviors of modifying breakfast content, receiving sunlight exposure and receiving exposure to low color temperature lighting at night can facilitate achievement of high plasma melatonin at night in humans.…”

Section: Discussionmentioning

confidence: 86%

A tryptophan-rich breakfast and exposure to light with low color temperature at night improve sleep and salivary melatonin level in Japanese students

Wada¹,

Yata²,

Akimitsu³

et al. 2013

J Circadian Rhythms

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BackgroundEpidemiological studies in Japan have documented an association between morning type and a tryptophan-rich breakfast followed by exposure to sunlight in children. The association may be mediated by enhanced melatonin synthesis, which facilitates sleep at night. However, melatonin is inhibited by artificial light levels with high color-temperature common in Japanese homes at night. In this study, we investigated whether a combination of tryptophan-rich breakfast and light with low color-temperature at night could enhance melatonin secretion and encourage earlier sleep times.MethodsThe intervention included having breakfast with protein- and vitamin B6 - rich foods and exposure to sunlight after breakfast plus exposure to incandescent light (low temperature light) at night (October-November, 2010). The participants were 94 members of a university soccer club, who were divided into 3 groups for the intervention (G1: no intervention; G2: asked to have protein-rich foods such as fermented soybeans and vitamin B6-rich foods such as bananas at breakfast and sunlight exposure after breakfast; G3: the same contents as G2 and incandescent light exposure at night). Salivary melatonin was measured around 11:00 p.m. on the day before the beginning, a mid-point and on the day before the last day a mid-point and on the last day of the 1 month intervention.ResultsIn G3, there was a significantly positive correlation between total hours the participants spent under incandescent light at night and the frequency of feeling sleepy during the last week (p = 0.034). The salivary melatonin concentration of G3 was significantly higher than that of G1 and G2 in combined salivary samplings at the mid-point and on the day before the last day of the 1 month intervention (p = 0.018), whereas no such significant differences were shown on the day just before the start of the intervention (p = 0.63).ConclusionThe combined intervention on breakfast, morning sunlight and evening-lighting seems to be effective for students including athletes to keep higher melatonin secretion at night which seems to induce easy onset of the night sleep and higher quality of sleep.

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“…The second component is that the high potential of melatonin synthesis based on the high serotonin synthesis in the pineal during daytime might be available due to the night exposure to the "low-temperature light" emitted from incandescent bulbs. Many reports have shown that melatonin secretion is suppressed by evening or night light emitted from fluorescent lamps including shortwave length (with around 460 nm of wave length) components [10,33,35,[54][55][56]. Moreover, this study newly implies that the combined behaviors of (1) modifying breakfast content, (2) receiving sunlight exposure, and (3) receiving exposure to low color temperature lighting at night can facilitate achievement of high plasma melatonin at night in humans.…”

Section: Discussionmentioning

confidence: 62%

Salivary Melatonin at Night: Responding to the Night Lighting and Cow’s Milk Consumption at Breakfast in Japanese Junior High and University Students

Takeuchi¹,

Harada²

2018

Melatonin - Molecular Biology, Clinical and Pharmaceutical Approaches

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(1) In junior high school students aged 14-15 years old, the salivary melatonin level increased rapidly from 3.00 pg/ml at 21:45 to 9.18 pg/ml at 23:40 under orange light from light bulb, whereas it remained at less than 1.3 pg/ml under white light from fluorescent lamp. (2) In 3 weeks of intervention on university athlete students, the salivary melatonin concentration at 23:00 of G3 (protein-rich breakfast and following sunlight exposure and orange light from the light bulb at night) after intervention was significantly higher than that of G1 (protein-poor breakfast and not following exposure to sunlight and white light from the fluorescent lamp at night) and G2 (protein-rich breakfast and following exposure to sunlight and white lights from the fluorescent lamp at night). (3) This study evaluates the effects of cow's milk intake (Group 1: G1) for 20 days at breakfast on saliva melatonin concentration at 22:00 and 23:00 on 0, 10, and 21 days of the intervention period in Japanese university male athletes attending a university soccer club. In the intervention group (G1), salivary melatonin concentration increased at 22:00 in comparison with that before intervention, but there was no significant change in the control group (Group 2: G2). On the other hand, there were no significant differences in the melatonin at 23:00 between the both groups just after 21 days of intervention. Intake of cow's milk at breakfast might make the circadian phase in advance in the soccer athletes.

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Variations in the Light-induced Suppression of Nocturnal Melatonin with Special Reference to Variations in the Pupillary Light Reflex in Humans

Abstract: The purpose of the present study was to elucidate

Cited by 16 publications

References 32 publications

Circadian and Wake-Dependent Effects on the Pupil Light Reflex in Response to Narrow-Bandwidth Light Pulses

Circadian and Wake-Dependent Effects on the Pupil Light Reflex in Response to Narrow-Bandwidth Light Pulses

A tryptophan-rich breakfast and exposure to light with low color temperature at night improve sleep and salivary melatonin level in Japanese students

Salivary Melatonin at Night: Responding to the Night Lighting and Cow’s Milk Consumption at Breakfast in Japanese Junior High and University Students

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