Variations in Systemic and Pulmonary Endothelin-1 in Horses with Recurrent Airway Obstruction (Heaves)

Benamou, A. E.; Art, Tatiana; Marlin, D. J.; Roberts, C. A.; Lekeux, Pierre

doi:10.1006/pupt.1998.0144

Cited by 24 publications

(33 citation statements)

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“…In the present study, the concentrations of ET‐1 were significantly greater in BALF and PELF from affected horses during exacerbation, compared with remission, and nonaffected controls during the summer. Our results resemble the findings in horses affected with barn‐associated RAO, whereby, despite the great variation of ET‐1 concentration in affected horses during crisis, the controls have significantly lower ET concentrations 7 . Similarly, our results also resemble those reported in human asthmatic patients where immunoreactive ET‐1 concentrations are found to be greater in BALF samples of asthmatic patients compared with normal subjects 13,14,21 .…”

Section: Discussionsupporting

confidence: 88%

“…In contrast, no difference between ET‐1 concentrations in plasma samples from asthmatics and control subjects is reported by others 22 . The circulating venous concentration of ET‐1 was greater in barn‐associated RAO‐affected horses during crisis compared with remission and control samples 7 …”

Section: Discussionmentioning

confidence: 70%

“…The lung is the major site of ET‐1 and ET‐3 expression, as well as ET clearance 5 . The most studied isoform, ET‐1, has been implicated in the pathogenesis of airway inflammatory diseases such as human asthma and equine barn‐associated RAO 6,7 …”

mentioning

confidence: 99%

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Plasma and Pulmonary Fluid Endothelin in Horses with Seasonal Recurrent Airway Obstruction

Costa

Eades

Venugopal

et al. 2009

Veterinary Internal Medicne

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Background: Summer pasture-associated recurrent airway obstruction (SPA-RAO), a seasonal airway obstructive disease of horses, is characterized by clinical exacerbation after exposure to pasture during warm months of the year. Endothelin (ET)-1, potent bronchoconstrictor, mitogen, secretagogue, and proinflammatory mediator, has been implicated in the pathogenesis of asthma and equine heaves.Hypothesis: Immunoreactive ET-1 concentrations increase during clinical exacerbation and return to basal values during periods of disease remission.Animals: Twelve horses, 6 affected with SPA-RAO and 6 nonaffected. Methods: Prospective, observational study. Bronchoalveolar lavage fluid (BALF), arterial and venous plasma samples, and clinical variables were obtained from affected horses during clinical exacerbation and remission. Samples and data of nonaffected horses were collected during the summer and winter on dates similar to affected horses. Immunoreactive ET-1 was determined using a commercial ELISA.Results: The median and range ET-1 concentrations (pg/ml) in arterial (1.3, 0.7-1.8) and venous (1.3, 1.2-1.7) plasma and in BALF (0.3, 0.2-0.4), and pulmonary epithelial lining fluid (PELF) (25.5, 21-50) were greater in affected horses during clinical exacerbation compared with remission (P o .01). The concentrations of immunoreactive ET-1 were greater in affected horses during clinical exacerbation compared with nonaffected horses (P o .05).Conclusions and Clinical Importance: During clinical exacerbation of SPA-RAO, ET-1 is increased in circulation and pulmonary secretions. Intervention with ET receptor antagonists should provide further information on the role of ET-1 in SPA-RAO.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 70%

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Plasma and Pulmonary Fluid Endothelin in Horses with Seasonal Recurrent Airway Obstruction

Costa

Eades

Venugopal

et al. 2009

Veterinary Internal Medicne

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“…In horses with obstructive pulmonary diseases, bronchoalveolar lavage fluid ET-1 concentrations are strongly correlated with severity of disease. 16 Thus, the high plasma concentrations of ET-like immunoreactivity in horses with large-intestinal strangulating obstructions, enterocolitis, and peritonitis may also correlate with the severity of endothelial damage and tissue injury and may indicate involvement of ET in the etiopathogenesis of these disorders. Alternatively, high ET-like immunoreactivity concentrations may have simply reflected a more severe systemic illness in these horses.…”

Section: Discussionmentioning

confidence: 94%

“…Plasma ET-like immunoreactivity in 29 healthy horses ranged from 1.09 to 3.2 pg/ml, which is in agreement with values reported previously for horses. 16 Within the affected group, median plasma concentration of ET-like immunoreactivity was greatest in horses with large-intestinal strangulating obstructions, enterocolitis, and peritonitis. Logistic regression analysis revealed an association between ET-like immunoreactivity and outcome, whereas regression analysis revealed an association between plasma ET-like immunoreactivity, PCV, and duration of signs of pain.…”

Section: Discussionmentioning

confidence: 97%