Variations in Respiratory Disease Morbidity Among Pulp and Paper Mill Town Residents

Deprez, Ronald D.; Oliver, L. Christine; Halteman, William A.

doi:10.1097/00043764-198607000-00007

Cited by 9 publications

(2 citation statements)

References 3 publications

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“…A cross-sectional study of occupational and community exposures to pulp and paper mill effluents (as measured by residential proximity to the source) was conducted by Deprez et al (110) for Maine mill towns. Hospitalization diagnoses included respiratory infections and inflammations, respiratory cancer, chronic obstructive pulmonary disease, bronchitis and asthma, respiratory signs and symptoms, all respiratory combined, myocardial infarction (controls), and total admissions.…”

Section: Cross-sectional Studies Of Hospitalizationmentioning

confidence: 99%

A Critical Review of Studies of the Association between Demands for Hospital Services and Air Pollution

Lipfert¹

1993

Environmental Health Perspectives

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Studies of the associations between air pollution and hospital admissions and emergency room use are reviewed, including studies of air pollution episodes, time-series analyses, and cross-sectional analyses. These studies encompass a variety of methods of analysis and levels of air quality. Findings from all three types of studies were generally consistent in that almost all of the studies reviewed found statistically significant associations between hospital use and air pollution; this unanimity may have resulted in part from publication bias. These associations were characterized by elasticities of the order of 0.20; i.e., a 100% change in air pollution was associated with a change in hospital use of about 20%, for specific diagnoses. Respiratory diagnoses were emphasized by most studies; cardiac diagnoses were included in five ofthem. The air pollutants most often associated with changes in hospital use were particulate matter, sulfur oxides, and oxidants. Apart from the major air pollution episodes, there was no obvious link between air pollution level and the significance or magnitudes of the associations. Long-term indicators of hospitalization appeared to also be influenced by medical care supply factors, including the numbers of beds and physicians per capita. These nonpathological causal factors could also have influenced the findings of the time-series studies by introducing extraneous factors in the patterns of admissions. Although consistent associations have been shown between hospital use and air pollution, further research is required to distinguish among potentially responsible pollutants and to deduce specific dose-response relationships of general utility.

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Section: Cross-sectional Studies Of Hospitalizationmentioning

confidence: 99%

A Critical Review of Studies of the Association between Demands for Hospital Services and Air Pollution

Lipfert¹

1993

Environmental Health Perspectives

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“…Thoren et al [31,32], Toren et al [33,34], and Deprez et al [8] reported that employment in paper mills was associated with an increased risk of bronchial asthma and chronic obstructive pulmonary disease. Ericsson et al [9] found a dose-dependent increase in upper respiratory symptoms among paper workers.…”

Section: Introductionmentioning

confidence: 99%

Effects of Recycled Paper Dust Extracts on Isolated Guinea Pig Trachea

Schachter

Zuśkin

Rienzi

et al. 1998

Lung

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The effect of paper dust collected at two different locations in a paper recycling plant (PD1 and PD2) on isolated nonsensitized guinea pig tracheal smooth muscle was studied in vitro. Dust extracts were prepared as a 1:10 w/v aqueous solution. Dose-related contractions of guinea pig tracheal rings were elicited with both PD1 and PD2. Pharmacologic studies were performed with atropine (10(-6) M), indometacin (10(-6) M), pyrilamine (10(-6) M), LY171883 (10(-5) M), nordihydroguaiaretic acid (10(-5) M), and TMB8 (10(-5) M). The possible role of endogenous neuropeptides in this constrictor process was studied by depleting neural mediators with capsaicin (5 x 10(-6) M) before challenge with dust extracts. Constrictor effects were partially inhibited by a wide variety of the mediator blocking agents. The effects of both extracts were almost totally inhibited by the anticholinergic agent atropine, suggesting that a principal pathway mediating this response may involve the parasympathetic nervous system. The intracellular calcium-blocking agent TMB8 also induced a reduction of the contractile responses to PD1 and PD2 consistent with the well established role of intracellular calcium in smooth muscle constriction. Pretreatment with capsaicin significantly increased the contractile activity of paper dust extracts but only at the higher doses of these extracts. This suggests that the effect of paper dust is not initiated by the release of mediators stored in sensory nerves but that the prerelease of these mediators may enhance the constrictor effects of these dusts. We suggest that paper dust extracts cause dose-related airway smooth muscle constriction possibly associated with the release of cholinergic as well as other mediators. The constrictor effect does not require tissue presensitization or the release of neuropeptides from sensory nerves.

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Air pollution impacts from a pulp and paper mill facility located in adjacent communities, Edmundston, New Brunswick, Canada and Madawaska, Maine, United States

Dionne

Walker

2021

Environmental Challenges

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Variations in Respiratory Disease Morbidity Among Pulp and Paper Mill Town Residents

Cited by 9 publications

References 3 publications

A Critical Review of Studies of the Association between Demands for Hospital Services and Air Pollution

A Critical Review of Studies of the Association between Demands for Hospital Services and Air Pollution

Effects of Recycled Paper Dust Extracts on Isolated Guinea Pig Trachea

Air pollution impacts from a pulp and paper mill facility located in adjacent communities, Edmundston, New Brunswick, Canada and Madawaska, Maine, United States

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