Variations in pattern of pubertal changes in girls.

Marshall, W. A.; Tanner, J. M.

doi:10.1136/adc.44.235.291

Cited by 5,297 publications

(3,439 citation statements)

References 8 publications

(18 reference statements)

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“…Tanner stage was assessed by a physician according to the wellestablished criteria of Marshall and Tanner. 16,17 Consistent with our earlier reports, [9][10][11][12][13] Tanner stage was expressed based upon breast development in girls and pubic hair growth in boys, those aspects of pubertal development that reflect the biological activity of gonadal steroid exposure in each sex (testosterone in boys and estrogen in girls). Gonadal steroids were not measured in this study.…”

Section: Out-patient Visitsupporting

confidence: 88%

Insulin sensitivity, insulin secretion and β-cell function during puberty in overweight Hispanic children with a family history of type 2 diabetes

et al. 2005

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OBJECTIVE:To examine cross-sectional differences in insulin sensitivity, insulin secretion and b-cell function during puberty in overweight Hispanic boys and girls with a family history of type 2 diabetes. STUDY DESIGN AND PARTICIPANTS: This cross-sectional, observational study included 214 8-13-y-old Hispanic children with a BMI percentile Z85th percentile and family history of type 2 diabetes. METHODS AND ANALYSES: Participants underwent a physical examination, body composition measures, oral glucose tolerance test (OGTT), and frequently-sampled intravenous glucose tolerance test. Unadjusted and adjusted general linear models (GLM) tested whether insulin/glucose dynamics differed by Tanner stage and gender. RESULTS: Unadjusted group comparisons showed that fasting insulin increased whereas insulin sensitivity (SI) and the disposition index (DI) (a measure of pancreatic b-cell function) decreased across Tanner stage groups (all Po0.05). No differences in the acute insulin response to glucose (AIRg), fasting glucose or 2-h glucose were found. After adjusting for covariates, there was no independent effect of Tanner stage on SI (P ¼ 0.9) or AIRg (P ¼ 0.2), but DI was slightly lower in later Tanner stages suggesting decreased b-cell function in the more mature groups (P ¼ 0.10). CONCLUSIONS: Overweight Hispanic children with a family history of type 2 diabetes may represent a unique population given that pubertal insulin resistance was not evident once analyses controlled for body composition. Longitudinal analyses are required to determine whether the slightly diminished b-cell function in later Tanner stages plays a role in the development of type 2 diabetes.

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Section: Out-patient Visitsupporting

confidence: 88%

Insulin sensitivity, insulin secretion and β-cell function during puberty in overweight Hispanic children with a family history of type 2 diabetes

et al. 2005

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“…Adrenal maturation (adrenarche), which is associated with increasing levels of the adrenal hormones, precedes gonadarche by a couple of years. Sexual maturity was assessed using Tanner staging21, 22 at the first clinic visit following initial symptoms for MS cases, and at the enrollment visit for controls.…”

Section: Methodsmentioning

confidence: 99%

Distinct effects of obesity and puberty on risk and age at onset of pediatric MS

Chitnis

Graves

Weinstock‐Guttman

et al. 2016

Ann Clin Transl Neurol

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ObjectiveThe aim of this study was to examine the relative contributions of body mass index (BMI) and pubertal measures for risk and age of onset of pediatric MS.MethodsCase–control study of 254 (63% female) MS cases (onset<18 years of age) and 420 (49% female) controls conducted at 14 U.S. Pediatric MS Centers. Sex‐ and age‐stratified BMI percentiles were calculated using CDC growth charts from height and weight measured at enrollment for controls, and within 1 year of onset for MS cases. Sex‐stratified associations between MS risk and age at symptom onset with both BMI and pubertal factors were estimated controlling for race and ethnicity.ResultsOnly 11% of girls and 15% of boys were prepubertal (Tanner stage I) at MS onset. 80% of girls had onset of MS after menarche. BMI percentiles were higher in MS cases versus controls (girls: P < 0.001; boys: P = 0.018). BMI was associated with odds of MS in multivariate models in postpubertal girls (OR = 1.60, 95% confidence interval [CI]: 1.12, 2.27, P = 0.009) and boys (OR = 1.43, 95% CI: 1.08, 1.88, P = 0.011). In girls with MS onset after menarche, higher BMI was associated with younger age at first symptoms (P = 0.031). Younger menarche was associated with stronger effects of BMI through mediation and interaction analysis. In pubertal/postpubertal boys, 89% of whom were obese/overweight, earlier sexual maturity was associated with earlier onset of MS (P < 0.001).InterpretationHigher BMI in early adolescence is a risk factor for MS in girls and boys. Earlier age at sexual maturity contributes to earlier age at MS onset, particularly in association with obesity.

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“…A licensed paediatric health‐care provider performed a detailed physical examination where Tanner staging was determined using established guidelines 20, 21. Height and weight were measured using a beam medical scale and wall‐mounted stadiometer to the nearest 0.1 kg and 0.1 cm, respectively, and the average of the two measurements was used for analysis.…”

Section: Methodsmentioning

confidence: 99%

Consumption of artificial sweetened beverages associated with adiposity and increasing HbA1c in Hispanic youth

et al. 2018

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SummaryResearch examining the impact of artificial sweetened beverages (ASBs) on obesity and metabolic diseases in adolescents is limited. The overall goal is to examine the longitudinal effects of ASBs on changes in adiposity and metabolic parameters in Hispanic adolescents. Longitudinal cohort with 98 Hispanics (12–18 years) who were overweight or had obesity with the following data at baseline and 1‐year later: anthropometrics, diet (24‐h recalls), body composition (DXA), glucose and insulin dynamics (oral glucose tolerance and frequently sampled intravenous glucose tolerance test) and fasting lipids. Repeated measures analyses of covariance assessed changes over time between control (no ASBs at either visit), ASB initiators (no ASBs at baseline/ASBs at 1‐year) and chronic ASB consumers (ASBs at both visits). ASB initiators (n = 14) and chronic ASB consumers (n = 9) compared to control (n = 75) had higher total body fat at baseline and 1‐year (P = 0.05 for group effect). Chronic ASB consumers had a 6% increase in haemoglobin A1c, 34% increase in energy intake (kcal d−1) and 39% increase in carbohydrate intake (g d−1) over time, while control and ASB initiators maintained (P < 0.05 for group‐by‐time interactions). These results do not support promoting ASBs as a strategy for adiposity loss or to improve metabolic health.

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Variations in pattern of pubertal changes in girls.

Cited by 5,297 publications

References 8 publications

Insulin sensitivity, insulin secretion and β-cell function during puberty in overweight Hispanic children with a family history of type 2 diabetes

Insulin sensitivity, insulin secretion and β-cell function during puberty in overweight Hispanic children with a family history of type 2 diabetes

Distinct effects of obesity and puberty on risk and age at onset of pediatric MS

Consumption of artificial sweetened beverages associated with adiposity and increasing HbA1c in Hispanic youth

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