In 2016, a tobacco product commonly referred to as nicotine pouches entered the US market. These prefilled, microfiber pouches contain nicotine powder that dissolves in the mouth without requiring spitting. Nicotine pouches contain nicotine salts that deliver high levels of nicotine with less irritation than the free-base nicotine in most smokeless tobacco products. 1,2 Nicotine is highly addictive, harms fetal development, and can harm brain development through age 25 years. 3 Leading smokeless tobacco manufacturers sell nicotine pouches in varying strengths and flavors as the brands on! (Altria), Velo (British American Tobacco [BAT]), and ZYN (Swedish Match). Marketing materials describe the products as "tobacco-free," "all white," and more discreet and convenient than electronic and conventional cigarettes. 2,4 The extent of nicotine pouch consumption is unknown. We assessed US nicotine pouch sales using retail scanner data.Methods | Data for all US sales of nicotine pouches from March 27, 2016, through June 13, 2020, were licensed from the Nielsen Company for convenience, club, discount, and dollar stores; mass merchandisers; supermarkets; pharmacies; and military commissaries in the contiguous 48 states and Washington, DC. National-level unit and dollar sales for each universal product code (UPC) were provided in 4-week aggregates.