Variations in Levels of Intercellular Adhesion Molecule-1 with Disease Course, in Rheumatoid Arthritis Patients

Sarithala, Vijaya; Koroy, Pavel; Yagoda, Alexander

doi:10.7860/jcdr/2018/35302.12044

Cited by 3 publications

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“…ICAM-1 was measured using an enzyme-linked immunosorbent assay (ELISA) in all but one study, which did not provide relevant details regarding the analytical method used [ 100 ]. Eighteen studies measured ICAM-1 in serum [ 81 – 86 , 88 , 89 , 91 , 92 , 94 , 105 , 107 , 109 , 111 , 114 , 116 , 118 ], 2 in plasma [ 104 , 115 ], while the remaining 4 did not provide relevant information [ 97 , 101 , 103 , 113 ]. RA duration was reported in 18 studies and ranged between 0.25 and 23 years [ 81 , 82 , 84 , 85 , 88 , 89 , 92 , 94 , 97 , 100 , 101 , 103 , 105 , 109 , 111 , 114 , 115 , 118 ], whereas DAS-28, reported in six studies, ranged between 2.8 and 6.23 [ 103 , 105 , 109 , 114 , 116 , 118 ].…”

Section: Resultsmentioning

confidence: 99%

“…Eighteen studies measured ICAM-1 in serum [ 81 – 86 , 88 , 89 , 91 , 92 , 94 , 105 , 107 , 109 , 111 , 114 , 116 , 118 ], 2 in plasma [ 104 , 115 ], while the remaining 4 did not provide relevant information [ 97 , 101 , 103 , 113 ]. RA duration was reported in 18 studies and ranged between 0.25 and 23 years [ 81 , 82 , 84 , 85 , 88 , 89 , 92 , 94 , 97 , 100 , 101 , 103 , 105 , 109 , 111 , 114 , 115 , 118 ], whereas DAS-28, reported in six studies, ranged between 2.8 and 6.23 [ 103 , 105 , 109 , 114 , 116 , 118 ]. Eleven studies reported data on methotrexate treatment [ 85 , 86 , 88 , 91 , 92 , 94 , 104 , 111 , 114 , 116 , 118 ], 18 on glucocorticoid treatment [ 81 , 84 , 86 , 88 , 91 , 92 , 94 , 97 ,…”

Section: Resultsmentioning

confidence: 99%

“…Eleven studies reported data on methotrexate treatment [ 85 , 86 , 88 , 91 , 92 , 94 , 104 , 111 , 114 , 116 , 118 ], 18 on glucocorticoid treatment [ 81 , 84 , 86 , 88 , 91 , 92 , 94 , 97 , 100 , 101 , 103 – 105 , 109 , 114 , 116 , 118 ], and 14 on DMARDs treatment [ 81 , 84 , 86 , 88 , 89 , 91 , 94 , 97 , 100 , 103 , 105 , 109 , 116 , 118 ]. The risk of bias was low in 11 studies [ 89 , 97 , 100 , 101 , 104 , 105 , 107 , 109 , 111 , 114 , 116 ], moderate in 12 [ 81 – 86 , 88 , 91 , 92 , 94 , 115 , 118 ], and high in the remaining 1 [ 103 ] (Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

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A systematic review and meta-analysis of circulating adhesion molecules in rheumatoid arthritis

Mangoni,

Zinellu

2024

Inflamm. Res.

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Background The availability of robust biomarkers of endothelial activation might enhance the identification of subclinical atherosclerosis in rheumatoid arthritis (RA). We investigated this issue by conducting a systematic review and meta-analysis of cell adhesion molecules in RA patients. Methods We searched electronic databases from inception to 31 July 2023 for case–control studies assessing the circulating concentrations of immunoglobulin-like adhesion molecules (vascular cell, VCAM-1, intercellular, ICAM-1, and platelet endothelial cell, PECAM-1, adhesion molecule-1) and selectins (E, L, and P selectin) in RA patients and healthy controls. Risk of bias and certainty of evidence were assessed using the JBI checklist and GRADE, respectively. Results In 39 studies, compared to controls, RA patients had significantly higher concentrations of ICAM-1 (standard mean difference, SMD = 0.81, 95% CI 0.62–1.00, p < 0.001; I2 = 83.0%, p < 0.001), VCAM-1 (SMD = 1.17, 95% CI 0.73–1.61, p < 0.001; I2 = 95.8%, p < 0.001), PECAM-1 (SMD = 0.82, 95% CI 0.57–1.08, p < 0.001; I2 = 0.0%, p = 0.90), E-selectin (SMD = 0.64, 95% CI 0.42–0.86, p < 0.001; I2 = 75.0%, p < 0.001), and P-selectin (SMD = 1.06, 95% CI 0.50–1.60, p < 0.001; I2 = 84.8%, p < 0.001), but not L-selectin. In meta-regression and subgroup analysis, significant associations were observed between the effect size and use of glucocorticoids (ICAM-1), erythrocyte sedimentation rate (VCAM-1), study continent (VCAM-1, E-selectin, and P-selectin), and matrix assessed (P-selectin). Conclusions The results of our study support a significant role of cell adhesion molecules in mediating the interplay between RA and atherosclerosis. Further studies are warranted to determine whether the routine use of these biomarkers can facilitate the detection and management of early atherosclerosis in this patient group. PROSPERO Registration Number: CRD42023466662.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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A systematic review and meta-analysis of circulating adhesion molecules in rheumatoid arthritis

Mangoni,

Zinellu

2024

Inflamm. Res.

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“…Activation/dysfunction of endothelium plays key role in the pathogenesis of RA, its manifestation, including the hyperproduction of adhesion molecules [6][7][8], responsible for the cellular migration, accumulation of immune cells and fibroblasts involved in the processes of destruction and proliferation of synovial membrane. Thus, in patients with RA increased plasma concentrations of molecules of immunoglobulin superfamily and selectins in severe course of disease was noticed, including with systemic (hematological) manifestations [6,7,9,10], which was not shared by other researchers [8].…”

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confidence: 87%

Biological therapy of rheumatoid arthritis: is it a real prediction of efficacy?

Vladimirovich¹,

Jawahar²,

Valentinovich³

2018

Medical news of the North Caucasus

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БИоЛоГИЧЕСКая ТЕраПИя рЕвмаТоИдНоГо арТрИТа: рЕаЛЬНа ЛИ ПрЕдИКЦИя ЭФФЕКТИвНоСТИ? П. в. Корой, в. д. Саритхала, а. в. ягода Ставропольский государственный медицинский университет, российская Федерация Relationship of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), plateletendothelial cell adhesion molecule-1 (PECAM-1), E-, P-and L-selectins blood levels with results of three-monthly combination treatment by biological agents and methotrexate was studied in 35 patients with rheumatoid arthritis (29 women, 6 men) at age from 40 to 66 with previous noneffective methotrexate treatment. Tocilizumab was applied in 20 patients, in 15 cases etanercept was used. The moderate effect of treatment was observed in 74.3 % of cases, remission or low activity of rheumatoid arthritis were reached in 22.9 % of patients, 9 patients were non-responders. Increase of blood concentration of all immunoglobulins superfamily molecules and of P-selectin was observed in rheumatoid arthritis. After 3 months of therapy decrease in VCAM-1, PECAM-1 blood levels and normalization of ICAM-1, P-selectin values were observed, especially in cases of effective treatment, in non-responders there was reduction only of ICAM-1 levels. The favorable response to treatment was associated with high initial levels of ICAM-1, РЕСАМ-1 and low levels of P-selectin in blood that opens new possibilities of use of adhesion molecules in prediction of successful therapy of RA.

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“…integrins, selectins, laminins, and fibronectins) and immunoglobulins. Gene expression of inflammatory cytokines is also increased, leading to neoangiogenesis in tissue [4,5]. These changes, together with activation of regional fibroblasts, cause the formation of inflammatory structural changes similar to those seen in RA [6].…”

Section: Introduction____________________________mentioning

confidence: 96%

Comparison of serum and synovial fluid markers of Herpes simplex virus and Helicobacter pylori infection between rheumatoid arthritis and osteoarthritis patients: A Retrospective Case-Control Study

et al. 2021

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43Recently, several infectious agents including Epstein-Barr virus and Escherichia coli have been suggested as possible contributing factors to the pathogenesis of rheumatoid arthritis (RA). This study was designed to compare serum and synovial fluid markers of herpes simplex virus (HSV) and Helicobacter pylori of RA and osteoarthritis (OA) patients. This comparative study was conducted on two hundred OA and RA patients who referred to the Rheumatic Diseases Research Center (RDRC) affiliated with Mashhad University of Medical Sciences, Mashhad, Iran, from March 2015 to 2016. Synovial fluid was obtained from all individuals. Two years later, participants attended a follow-up session to collect blood samples for serum markers of these two infectious agents. Twenty-five patients (96.15%) in the RA group and 23 individuals (92%) in the OA group had positive serum IgG antibodies for HSV. As for Helicobacter pylori, 13 individuals (50%) in RA and 12 individuals (48%) had positive serum IgG antibodies (p value = 0.66). In addition, 9 (34.6%) and 8 (30.8%) in the RA group and 10 (40%) and 3 (12%) in the OA group had positive serum IgA and IgM antibodies for Helicobacter pylori, respectively (p value = 0.89 and p value = 0.13, respectively). Collected fluid samples were negative for both Helicobacter pylori and HSV1 and 2 DNA particles in all individuals. Based on the results of the current study, there is no difference between RA and OA patients in terms of Herpes simplex virus and Helicobacter pylori infection.

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Variations in Levels of Intercellular Adhesion Molecule-1 with Disease Course, in Rheumatoid Arthritis Patients

Cited by 3 publications

References 0 publications

A systematic review and meta-analysis of circulating adhesion molecules in rheumatoid arthritis

A systematic review and meta-analysis of circulating adhesion molecules in rheumatoid arthritis

Biological therapy of rheumatoid arthritis: is it a real prediction of efficacy?

Comparison of serum and synovial fluid markers of Herpes simplex virus and Helicobacter pylori infection between rheumatoid arthritis and osteoarthritis patients: A Retrospective Case-Control Study

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