Variations in genes regulating neuronal migration predict reduced prefrontal cognition in schizophrenia and bipolar subjects from mediterranean Spain: A preliminary study

Tabarés‐Seisdedos, Rafael; Escámez, Teresa; Martínez-Giménez, J.A.; Balanzá, Vicent; Salazar, José; Selva, Gabriel; Rubio, Claudia Grau; Vieta, Eduard; Geijo-Barrientos, Emilio; Martínez‐Arán, Anabel; Reiner, Orly; Martı́nez, Salvador

doi:10.1016/j.neuroscience.2006.01.054

Cited by 45 publications

(27 citation statements)

References 70 publications

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“…378 Independent genetic evidence for TP53 as a schizophrenia susceptibility gene is strong, with five of six studies reporting significant association. [379][380][381][382][383] Genotype and allele frequencies at MspI polymorphisms of TP53 are likewise significantly different between Korean schizophrenia and lung cancer subjects.…”

Section: Discussionmentioning

confidence: 95%

Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer

Tabarés‐Seisdedos

Rubenstein²

2009

Mol Psychiatry

213

157

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Section: Discussionmentioning

confidence: 95%

Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer

Tabarés‐Seisdedos

Rubenstein²

2009

Mol Psychiatry

213

157

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“…Additionally this selective-and relative-scale texture (using the ratio of different scales of textures is also likely to be generally robust across different centres using differen MR systems) quantification approach also benefits from the lack of a priori nature of the mathematical model and shape description of local structure boundaries. Speculatively, intensity differences and inhomogeneity in fine grey-matter texture may reflect the consequences of the cortical thickness of histological perturbations, for example abnormal pyramidal cell clustering [22,23], synaptic pruning [24] and cell migration [25], within cortical layers reported in the brains of schizophrenic patients. Similarly, textural measures over other distinct spatial frequencies may be tuned to abnormalities in myelination [26,27] and gyrification.…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional textural analysis of brain images reveals distributed grey-matter abnormalities in schizophrenia

et al. 2009

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“…Moreover, LIS1 is a well-known causative gene for human lissencephaly, a condition which may predispose the patient to autistic-spectrum disorders (Kato and Dobyns, 2003). Interestingly, Lis1 binds to the disrupted in schizophrenia 1 protein and it has been implicated in schizophrenia (Lipska et al, 2006;Tabares-Seisdedos et al, 2006). Hence, interactions of genes involved in reelin signaling may provide insights into etiologies not only for lissencephaly, but also for various neurodevelopmental disorders that include certain aspects of autism and schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Neuroanatomical phenotypes in the Reeler mouse

et al. 2007

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The reeler mouse (Reln) has been proposed as a neurodevelopmental model for certain neurological and psychiatric conditions and has been studied by qualitative histochemistry and electron microscopy. Using magnetic resonance microscopy (MRM), we have quantitated for the first time the neuromorphology of Reln mice at a resolution of 21.5 m. The neuroanatomical phenotypes of heterozygous and homozygous mutant Reln mice were compared to those of wild type (WT) littermates using morphometry and texture analysis. The cortical, hippocampal, and cerebellar phenotypes of the heterozygous and homozygous mutant Reln mice were confirmed, and new features were revealed. The Reln rl/rl mice possessed a smaller brain, and both Reln rl/+ and Reln rl/rl mice had increased ventricles compared to WT controls. Shape differences were found between WT and Reln rl/rl brains, specifically in cerebellum, olfactory bulbs, dorsomedial frontal and parietal cortex, certain regions of temporal and occipital lobes, as well as in the lateral ventricles and ventral hippocampus. These findings suggest that certain brain regions may be more severely impacted by the Reln mutation than others. Gadolinium-based active-staining demonstrated that layers of the hippocampus were disorganized in Reln rl/rl mice and differences in thickness of these layers were identified between WT and Reln rl/rl mice. The intensity distributions characteristic to the dorsal, middle, and ventral hippocampus were altered in the Reln rl/rl , especially in the ventral hippocampus. These differences were quantified using skewness and modeling the intensity distributions with a Gaussian mixture. Our results suggest that structural features of Reln rl/rl brain most closely phenocopy those of patients with Norman-Roberts lissencephaly.

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Variations in genes regulating neuronal migration predict reduced prefrontal cognition in schizophrenia and bipolar subjects from mediterranean Spain: A preliminary study

Cited by 45 publications

References 70 publications

Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer

Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer

Three-dimensional textural analysis of brain images reveals distributed grey-matter abnormalities in schizophrenia

Neuroanatomical phenotypes in the Reeler mouse

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