Variations in fibrinolytic activity of human whole saliva

Majerus, Patrick; Dalcette, Benoit; Hermans, Marh; Pourtois, Michel; Capel, Paul D.

doi:10.1111/j.1600-0722.1996.tb00089.x

Cited by 10 publications

(15 citation statements)

References 11 publications

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“…Thus, after surgery, fibrinolysis is triggered. 2 Some patients have a tendency to bleed excessively after trauma. Surgery is the main oral healthcare hazard to the patient with a bleeding tendency, but regional block local anesthetic injections also may be a hazard because bleeding into the fascial spaces of the neck can threaten airway patency.…”

mentioning

confidence: 99%

Oral surgery in patients on anticoagulant therapy

Scully¹,

Wolff²

2002

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

132

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mentioning

confidence: 99%

Oral surgery in patients on anticoagulant therapy

Scully¹,

Wolff²

2002

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

132

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“…Some authors suggest perioperative systemic use of antifibrinolytics with local topical use of these drugs either applied directly in the wound, or in the form of mouthwash solution. 9,12,14,16,17,[22][23][24][25]27,32,37 Saliva and gingival sulcus fluid contain plasminogen and plasminogen activators and do not contain plasminogen inhibitors, [42][43][44] and mouthwash is often used as a 5% solution for 5-7 days after the procedure. If used orally, the drug will show antifibrinolytic activity in the blood, but not in saliva.…”

Section: Discussionmentioning

confidence: 99%

Current state of play regarding dental extractions in patients with haemophilia: Consensus or evidence‐based practice? A review of the literature

Bajkin

Dougall

2020

Haemophilia

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Due to the global prevalence of oral disease, tooth extraction is the most common surgical procedure required in general population thus likely to be similarly common in patients with haemophilia, especially those in older age and those living in countries with restricted resources. There are little or no consensus about optimal level and duration of factor replacement (FRP) therapy required to prevent bleeding complication following surgery and low levels of evidence to inform protocols and guidelines. The goal of this article was to review the literature regarding haematological treatment protocols and to assess their effectiveness in prevention of bleeding complications during and after tooth extractions in people with haemophilia. A total number of 29 articles were identified. Only two of the studies were randomized controlled trials, and meta‐analysis was not possible. Significant heterogeneity regarding haematological regimes, dental surgical procedures, disease severity and sample size of published studies which are unable to reliably inform the provision of safe dental surgery was noted. Based on the haematological regimens, all studies were classified into one of three groups: pre‐ and postoperative FRP or DDAVP, single preoperative FRP or DDAVP, and no FRP treatment. The overall reported bleeding rate in case of both pre‐ and postoperative FRP and single dose FRP preoperative is similar, 11.9% and 11.4%, respectively, indicating that minimizing the use of clotting factor concentrate is possible if proper local haemostatic measures are provided. Strictly designed prospective studies with higher number of patients are necessary to get firm conclusions about optimal FRP treatment required to prevent bleeding complications during and after oral surgery in patients with haemophilia.

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“…The plasminogen activation system appears to be active in human saliva. Many studies have evaluated the effects Table 1 Tissue plasminogen activator (tPA) activity, inhibition, and plasminogen activator inhibitor 2 (PAI-2) antigen in human saliva ( of circadian rhythm, age, gender and stimulation on the flow rate and composition of saliva (11,17,18). The plasminogen activation system may be part of this, especially the balance between PAs and PAIs.…”

Section: Discussionmentioning

confidence: 99%

Plasminogen activators and their inhibitors in human saliva and salivary gland tissue

Virtanen

Sirén

Multanen

et al. 2006

European J Oral Sciences

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The purpose of this study was to identify plasminogen activators (PA) and their specific inhibitors in human cell-free saliva and to investigate their expression in salivary gland tissue. Saliva samples were obtained from 34 patients visiting a neurological out-patient department. The activities of tissue and urokinase plasminogen activators (tPA and uPA, respectively), the relative inhibition of tPA, and the amounts of plasminogen activator inhibitors 1 and 2 (PAI-1 and PAI-2, respectively) in cell-free saliva were studied. The activities of tPA and uPA, and tPA inhibition, were measured using in-house microtiter plate assays, and PAI-1 and PAI-2 levels were measured using commercial enzyme-linked immunosorbent assay (ELISA) kits. Immunohistochemistry was used to evaluate the expression of PAs and PAIs in the salivary gland. Tissue plasminogen activator activity was found in most samples, with a mean activity of 0.63 IU ml(-1). uPA was observed in only a few samples. PAI-1 was not detected, but PAI-2 was present in all samples (with a mean value of 11.1 ng ml(-1)). The mean PAI-2 level in women was 12.4 and in men was 7.6 ng ml(-1). The activity of tPA and the relative inhibition of tPA seemed to be inversely associated. Tissue plasminogen activator, PAI-1, and PAI-2 were evident in salivary gland tissue, whereas the expression of uPA was low. The tPA activity in saliva suggests an active proteolysis. Plasminogen activator inhibitor 2 was found to be the main inhibitor of PAs in saliva.

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Variations in fibrinolytic activity of human whole saliva

Cited by 10 publications

References 11 publications

Oral surgery in patients on anticoagulant therapy

Oral surgery in patients on anticoagulant therapy

Current state of play regarding dental extractions in patients with haemophilia: Consensus or evidence‐based practice? A review of the literature

Plasminogen activators and their inhibitors in human saliva and salivary gland tissue

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