The revolution in cardiac care over the past two decades, characterized by emergent revascularization, drug eluting stents, anti-platelet medications, and advanced imaging has had little impact on overall ACS recurrence, or ACS prevention. The "Perfect Storm" refers to a confluence of events and processes, including atherosclerotic plaque, coronary flow dynamics, hemostatic and fibrinolytic function, metabolic and inflammatory conditions, neurohormonal dysregulation, and environmental events that give rise to, and result in an ACS event. In this article we illustrate the limits of the traditional main effect research model, giving a brief description of the current state of knowledge regarding the development of atherosclerotic plaque and the rupturing of these plaques that defines an ACS event. We then apply the Perfect Storm conceptualization to describe a program of research concerning a psychosocial vulnerability factor that contributes to increased risk of recurrent ACS and early mortality, and that has defied our efforts to identify underlying pathophysiology and successfully mount efforts to fully mitigate this risk.There is a "Perfect Storm" coming. Although this metaphor has been used to warn us about the ongoing U.S. fiscal crisis and about impending weather events, it is also a potentially useful metaphor when applied to the occurrence of an acute coronary syndrome (ACS). 1,2 The "Perfect Storm" as a conceptual model applied to ACS proposes to us that ACS events are not caused by the presence of a single, or even a number of specific coronary heart disease (CHD) risk factors, but rather results from an unfortunate confluence involving any of several stable underlying CHD vulnerability factors and the co-occurrence of any of several situational or environmental events that acutely activate critical physiological processes, thereby contributing overall to a period of increased risk. 3 Thus the "Perfect" ACS storm is defined as the joint presence of many co-occurring pathophysiologic processes that lead to a clinical event. This Perfect Storm will happen for more than 1 million American adults each year. Many of these individuals will join the more than 17 million living American adults who have survived an ACS but continue to suffer from the cardiovascular damage remaining after the ACS event. 4 Understanding how the Perfect Storm model aids in the investigation of this large public health problem is an exciting © 2013 Elsevier Inc. All rights reserved.Correspondence should be addressed to: Karina W. Davidson, Center for Behavioral Cardiovascular Health, Department of Medicine, Columbia University Medical Center, PH9, Room 9-319, 622 W. 168th Street, New York, NY 10032, kd2124@columbia.edu.
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