Variations in comorbidity burden in people with type 2 diabetes over disease duration: A population-based analysis of real world evidence

Pearson‐Stuttard, Jonathan; Holloway, Sara; Polya, Rosie; Sloan, Richard G.; Zhang, Linxuan; Gregg, Edward W.; Harrison, Katy; Elvidge, Jamie; Jónsson, Páll; Porter, Thomas R.

doi:10.1016/j.eclinm.2022.101584

Cited by 39 publications

(25 citation statements)

References 23 publications

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“…However, existing therapeutic agents are not effective in alleviating the development of diabetes and depression comorbidity. Although there have been several findings suggesting that chronic inflammation is a common link between diabetes and depression [ 7 , 31 ], few studies have attempted anti-inflammation approaches for the treatment of diabetes with depression [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Glucagon-like Peptide 1 Receptor Activation Inhibits Microglial Pyroptosis via Promoting Mitophagy to Alleviate Depression-like Behaviors in Diabetic Mice

Yang

Wang

et al. 2022

Nutrients

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Depression is a frequent and serious comorbidity associated with diabetes which adversely affects prognosis and quality of life. Glucagon-like peptide-1 receptor (GLP-1R) agonists, widely used in the treatment of diabetes, are reported to exert neuroprotective effects in the central nervous system. Thus, we aim to evaluate whether GLP-1R agonist exendin-4 (EX-4) could alleviate depression-like behaviors in diabetic mice and to explore its underlying mechanism. The antidepressant effects of EX-4 were evaluated using behavioral tests in db/db mice. The effects of EX-4 on microglial pyroptosis and neuroinflammation were assessed in N9 microglial cells. EX-4 administration alleviated depression-like behaviors in diabetic db/db mice. GLP-1R activation by EX-4 significantly suppressed microglial pyroptosis and neuroinflammation by downregulation of gasdermin D (GSDMD) and interleukin (IL)-1β in diabetic mice and lipopolysaccharide (LPS)-primed N9 microglia. Mechanistically, GLP-1R activation improved mitochondrial function and promoted mitophagy by decreasing the accumulation of mitochondrial reactive oxygen species (mtROS) and intracellular ROS production. EX-4 exhibits antidepressant effects in depression associated with diabetes in diabetic mice, which may be mediated by inhibiting microglial pyroptisis via promoting mitophagy. It is supposed that GLP-1R agonists may be a promising therapy in depression associated with diabetes.

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Section: Discussionmentioning

confidence: 99%

Glucagon-like Peptide 1 Receptor Activation Inhibits Microglial Pyroptosis via Promoting Mitophagy to Alleviate Depression-like Behaviors in Diabetic Mice

Yang

Wang

et al. 2022

Nutrients

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“…T2DM is a chronic disease [39] and often presents at least one comorbidity in patients [40][41][42][43]. Demographic data shows the prevalence of T2DM in male adults over 65 years [39,[44][45][46]. This may suggest the presence of a differential behavior which may be explained at molecular level.…”

Section: Using Noma-db For Studying Gene Changes With Agementioning

confidence: 99%

Sex Age Annotated Omics Data: Enabling Powerful Omics Studies

Guzzi¹,

Cortese²,

Giancotti³

et al. 2023

Preprint

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There is increasing evidence that many molecular processes exhibit differences with age 1 and sex. Such differences produces also differences in the insurgence and progression of many 2 complex diseases. For instances, demographic data on insurgence of comorbidities of mellitus 3 diabetes, on lethality of COVID-19, and on some cancers, shows differences between sex and age 4 groups. Therefore, the growing interest on such area requires the management of related data as 5 well as the development of algorithms and tool for the analysis. The availability of omics data 6 annotated with metadata related to age and sex is mandatory for building pipeline of the analysis. 7 The number of databases containing data related to age and sex is hencefort growing. We here show 8 some databases and tools storing such data. Finally, future research direction are highlighte

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“…The most common comorbidities experienced by geriatrics patients in this study were hypertension (n = 56; 22.86%), then dyslipidemia (n = 52; 21.22%), myalgia (n = 13; 5.31%) and osteoarthritis (n = 12; 4.9%) (Table 1). Previous studies have shown that people with T2DM have two or more comorbidities, even though the comorbidity profiles varies [13]. The regular use of five or more medicines is a common definition of polypharmacy [14].…”

Section: Patient Characteristicsmentioning

confidence: 99%

Drug-related problems in elderly patients with diabetes: A study in primary health care setting

Cahyaningsih¹,

Maziyyah²

2023

J Adv Pharm Educ Res

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Variations in comorbidity burden in people with type 2 diabetes over disease duration: A population-based analysis of real world evidence

Cited by 39 publications

References 23 publications

Glucagon-like Peptide 1 Receptor Activation Inhibits Microglial Pyroptosis via Promoting Mitophagy to Alleviate Depression-like Behaviors in Diabetic Mice

Glucagon-like Peptide 1 Receptor Activation Inhibits Microglial Pyroptosis via Promoting Mitophagy to Alleviate Depression-like Behaviors in Diabetic Mice

Sex Age Annotated Omics Data: Enabling Powerful Omics Studies

Drug-related problems in elderly patients with diabetes: A study in primary health care setting

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