Variations in Chemical Composition and Bioactive Compounds of <i>Thymus kotschyanus</i> Boiss<i>.</i> &amp; Hohen Populations Originated from Different Collection Sites

Tohidi, Behnaz; Rahimmalek, Mehdi; Arzani, Ahmad

doi:10.1080/0972060x.2018.1533435

Cited by 13 publications

(4 citation statements)

References 30 publications

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“…T. migricus is a perennial plant with pinkish blooms that belongs to the section Kotschyani and is one of the endemic species cultivated in Iran. It is a well-known fragrant plant in northwest Iran, where it is frequently used for herbal tea and as a flavoring ingredient [ 7 ]. Members of the genus Thymus L. are recognized for their therapeutic qualities, which include antibacterial, antimicrobial, antiviral ( T. vulgaris L.), and antifungal ( T. daenensis Celak.)…”

Section: Introductionmentioning

confidence: 99%

Effect of Methyl Jasmonate on Thymol, Carvacrol, Phytochemical Accumulation, and Expression of Key Genes Involved in Thymol/Carvacrol Biosynthetic Pathway in Some Iranian Thyme Species

Kianersi

Pour-Aboughadareh

Majdi

et al. 2021

IJMS

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Thyme species are a good source of thymol and carvacrol, which play a key role in controlling diseases. For the first time, the expression patterns of γ-terpinene synthase (TPS2), CYP71D178, and CYP71D180 genes and the amount of phenolics compounds were evaluated in T. migricus and T. daenensis after different methyl jasmonate (MeJA) treatments. The highest thymol and carvacrol contents were observed in T. migricus (86.27%) and T. daenensis (17.87%) at MeJA 100 µM, which was consistent with the expression patterns of the three investigated genes. All species treated showed high total phenolic and flavonoid content compared to control plants for which the highest amounts were observed in T. vulgaris treated with 100 µM and 10 µM MeJA. Furthermore, in the 100 µM MeJA treatment, the relative expression of TPS2 and CYP71D178 in T. migricus increased 7.47 and 9.86-fold compared with the control, respectively. The highest level of CYP71D180 transcripts (5.15-fold) was also observed for T. daenensis treated. This finding highlights the notion that thymol was known as the dominant component of the essential oil rather than carvacrol in diffident thyme species. This implies that MeJA at different concentrations influenced metabolic pathways and induced expression changes, resulting in a rise in essential oil levels.

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Section: Introductionmentioning

confidence: 99%

Effect of Methyl Jasmonate on Thymol, Carvacrol, Phytochemical Accumulation, and Expression of Key Genes Involved in Thymol/Carvacrol Biosynthetic Pathway in Some Iranian Thyme Species

Kianersi

Pour-Aboughadareh

Majdi

et al. 2021

IJMS

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“…The results of clustering of similar germplasm (19 Iranian populations (11 species including T. vulgaris )) were previously reported using phytochemical attributes [2,30] . Thus, a cluster analysis was carried out based on data of main EO components, obtained from GC/MS analysis by Tohidi et al [2] .…”

Section: Resultsmentioning

confidence: 82%

“…Thus, a cluster analysis was carried out based on data of main EO components, obtained from GC/MS analysis by Tohidi et al [2] . and Tohidi et al [30] . Accordingly, the resultant dendrogram divided the studied populations with different ploidy levels into three main clusters ( Figure 4).…”

Section: Resultsmentioning

confidence: 99%

Variation in Phytochemical, Morphological, and Ploidy Levels of Iranian Thymus Species

Tohidi

Rahimmalek

Arzani

2021

Chemistry & Biodiversity

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Thymus is one of the most important genera of the Lamiaceae family. This work was performed to assess inter and intra species variation, which is an indispensable prerequisite for the selection and the exploitation of the germplasm, using yield, secondary metabolites, and ploidy level criteria. Nineteen Iranian populations belonging to 11 Thymus species which includes T. vulgaris were used in this study. The results of cytological observations on the 19 populations revealed the three root‐tip chromosome numbers of 2n=2x=30, 2n=4x=56 or 60 (diploid and tetraploid). This study also presents the results of a two‐year field experiment that evaluates the agronomic and morphology of the 19 populations of Thymus spp. Cluster analysis grouped the populations into six groups and explained the relationships among ploidy levels, morphological traits, and essential oils (EOs). In general, diploid species belonged to the thymol chemotype, whilst carvacrol chemotype consistently dependent on the gene‐dosage effect. Thymus migricus, T. daenensis‐2, T. serpyllum, and T. trautvetteri populations with diverse thymol background were the best selection as the parents to improve thymol in a breeding program. Moreover, dry and fresh weight criteria can be used to improve EO content in thyme. Achieving this goal would be expected by crossing T. migricus and T. daenensis‐2. Finally, providing relevant information on the ploidy level of Thymus species, with emphasis on morphology and EO components variations, may be recommended for the selection of populations or species to improve bioactive components as well as morphological traits in future breeding programs.

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“…Oil components of Thymus kotschyanus are comprised of thymol, carvacrol, paracymene, linalool, and geraniol. (10)(11)(12)(13)(14) By comparison between the anti-in ammatory effect of Thymus kotschyanus and indomethacin, the paw`s edema in rats was decreased up to a greater extent after high dosages of the plant administration (15) Thymol and carvacrol, exert their anti-in ammatory effect by suppressing the transcription of Th1and Th2 cytokines and reducing the oxidative stress in in amed tissue. In addition, IL-10, the main anti-in ammatory cytokine, is enhanced by thymol administration (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the efficacy of Thymus kotschyanus extract as an additive treatment in patients with ulcerative colitis: a randomized double-blind placebo-controlled trial

et al. 2022

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Background: Ulcerative colitis (UC) is one of the chronic diseases which is increasing in prevalence and patients suffer from illness are-ups. UC standard regimen treatment has various side effects besides the e cacy, so there is an interest in administering complementary medicine to reduce adverse effects and increase the e cacy, as well. The aim of this study was to evaluate the e cacy and anti-in ammatory effect of Thymus kotschyanus as an additive treatment in a randomized double-blind placebo-controlled trial of UC patients.Methods: Thirty UC out-patients with mesalazine regimen treatment that ful lled the inclusion criteria were participated in a 12-week trial and were randomly chosen for the treatment and control group.Fifteen patients were administered a placebo as a control and 15 patients were administered received Thymus kotschyanus extract by a dose of 0.5 grams in a day in the treatment group. Laboratory tests were performed at baseline and week 12. The primary outcome was reduction in fecal calprotectin as the main intestine in ammatory marker. Likewise, reduction in SCCAI, SIDBQ, and SEO indices were considered as the secondary aims. The primary outcome was a reduction in SCCAI as the main intestine in ammatory marker. Likewise, reduction in fecal calprotectin, SIDBQ, and SEO indices were the secondary aims.Results: Fecal calprotectin Comparing the treatment and placebo groups at week 12 indicated a was decreased in fecal calprotectin by 54.74% in the treatment group, as compared with placebo group at week 12 (p=0.02). and alsoA signi cant difference reduction was shown in SCCAI was also shown between two study groups (p=0.01). Thymus kotschyanus extract was safe and no severe side effects were reported.Conclusion: Administration of Thymus kotschyanus revealed improvement in UC symptoms by the intestinal anti-in ammation effect of the plant and could be suggested as a potential additive treatment in UC patients. The study protocol has been registered under the identi cation code: IRCT20200406046965N2.

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Variations in Chemical Composition and Bioactive Compounds of Thymus kotschyanus Boiss. & Hohen Populations Originated from Different Collection Sites

Cited by 13 publications

References 30 publications

Effect of Methyl Jasmonate on Thymol, Carvacrol, Phytochemical Accumulation, and Expression of Key Genes Involved in Thymol/Carvacrol Biosynthetic Pathway in Some Iranian Thyme Species

Effect of Methyl Jasmonate on Thymol, Carvacrol, Phytochemical Accumulation, and Expression of Key Genes Involved in Thymol/Carvacrol Biosynthetic Pathway in Some Iranian Thyme Species

Variation in Phytochemical, Morphological, and Ploidy Levels of Iranian Thymus Species

Evaluation of the efficacy of Thymus kotschyanus extract as an additive treatment in patients with ulcerative colitis: a randomized double-blind placebo-controlled trial

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