Variation within Variation: Comparison of 24-h Rhythm in Rodent Infarct Size between Ischemia Reperfusion and Permanent Ligation

Pré, Bastiaan Du; Veen, Toon van; Crnko, Sandra; Vos, Marc A.; Deddens, Janine C.; Doevendans, Pieter A.; Laake, Linda van

doi:10.3390/ijms18081670

Cited by 10 publications

(10 citation statements)

References 26 publications

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“…Studies in rodents have shown that the time of day at which an ischemia is triggered can influence the severity of a myocardial infarction [ 16 , 17 , 18 ]. Indeed, the infarct size in hearts subjected to ischemia at the sleep-to-wake transition was significantly increased compared to hearts subjected to ischemia at the wake-to-sleep transition.…”

Section: Resultsmentioning

confidence: 99%

Anaesthesia-Induced Transcriptomic Changes in the Context of Renal Ischemia Uncovered by the Use of a Novel Clamping Device

Verney

Legouis

Placier

et al. 2021

IJMS

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Ischemia is a common cause of acute kidney injury worldwide, frequently occurring in patients undergoing cardiac surgery or admitted to the intensive care unit (ICU). Thus, ischemia-reperfusion injury (IRI) remains one of the main experimental models for the study of kidney diseases. However, the classical technique, based on non-traumatic surgical clamps, suffers from several limitations. It does not allow the induction of multiple episodes of acute kidney injury (AKI) in the same animal, which would be relevant from a human perspective. It also requires a deep and long sedation, raising the question of potential anaesthesia-related biases. We designed a vascular occluding device that can be activated remotely in conscious mice. We first assessed the intensity and the reproducibility of the acute kidney injury induced by this new device. We finally investigated the role played by the anaesthesia in the IRI models at the histological, functional and transcriptomic levels. We showed that this technique allows the rapid induction of renal ischemia in a repeatable and reproducible manner, breaking several classical limitations. In addition, we used its unique specificities to highlight the renal protective effect conferred by the anaesthesia, related to the mitigation of the IRI transcriptomic program.

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Section: Resultsmentioning

confidence: 99%

Anaesthesia-Induced Transcriptomic Changes in the Context of Renal Ischemia Uncovered by the Use of a Novel Clamping Device

Verney

Legouis

Placier

et al. 2021

IJMS

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“…Myocardial infarction (MI) leading to heart failure (HF) was induced in 8-week-old mice by LAD ligation, as described [39,41]. All surgeries were performed between ZT01-ZT04, as this is consistent with prior studies and findings that MI tolerance is time-of-day dependent [18,39,41,72]. Briefly, mice were anesthetized with isoflurane, intubated, and ventilated (Harvard Apparatus model 687) throughout the surgery.…”

Section: Left Anterior Descending (Lad) Coronary Artery Ligationmentioning

confidence: 96%

“…(caption on next page) P. Mistry, et al Journal of Molecular and Cellular Cardiology 149 (2020) [54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72] also being developed to promote the transfer of a multi-species community to recipients [86,87].…”

Section: Tablementioning

confidence: 99%

Circadian influence on the microbiome improves heart failure outcomes

Mistry

Reitz

Khatua

et al. 2020

Journal of Molecular and Cellular Cardiology

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Myocardial infarction (MI) leading to heart failure (HF) is a major cause of death worldwide. Previous studies revealed that the circadian system markedly impacts cardiac repair post-MI, and that light is an important environmental factor modulating the circadian influence over healing. Recent studies suggest that gut physiology also affects the circadian system, but how it contributes to cardiac repair post-MI and in HF is not well understood. To address this question, we first used a murine coronary artery ligation MI model to reveal that an intact gut microbiome is important for cardiac repair. Specifically, gut microbiome disruption impairs normal inflammatory responses in infarcted myocardium, elevates adverse cardiac gene biomarkers, and leads to worse HF outcomes. Conversely, reconstituting the microbiome post-MI in mice with prior gut microbiome disruption improves healing, consistent with the notion that normal gut physiology contributes to cardiac repair. To investigate a role for the circadian system, we initially utilized circadian mutant Clock ∆19/∆19 mice, revealing that a functional circadian mechanism is necessary for gut microbiome benefits on post-MI cardiac repair and HF. Finally, we demonstrate that circadian-mediated gut responses that benefit cardiac repair can be conferred by time-restricted feeding, as wake time feeding of MI mice improves HF outcomes, but these benefits are not observed in MI mice fed during their sleep time. In summary, gut physiology is important for cardiac repair, and the circadian system influences the beneficial gut responses to improve post-MI and HF outcomes.

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“…Not only food intake but also numerous cardiac parameters have a peculiar daily rhythm: blood pressure and heart rate are characterized by daily fluctuations ( 71 – 73 ). Moreover, numerous epidemiological studies have revealed that various adverse cardiac events, i.e., myocardial ischemia, sudden cardiac death, and ventricular fibrillation, occur more frequently during the morning ( 74 – 76 ). At molecular levels, different components of the cardiovascular system express circadian genes from smooth muscle cells ( 77 , 78 ) to cardiomyocytes ( 79 , 80 ).…”

Section: The Circadian System: An Orchestra Of Signals Synchronizes F...mentioning

confidence: 99%

Chrono-communication and cardiometabolic health: The intrinsic relationship and therapeutic nutritional promises

Senesi

Ferrulli²,

Luzi³

et al. 2022

Front. Endocrinol.

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Circadian rhythm, an innate 24-h biological clock, regulates several mammalian physiological activities anticipating daily environmental variations and optimizing available energetic resources. The circadian machinery is a complex neuronal and endocrinological network primarily organized into a central clock, suprachiasmatic nucleus (SCN), and peripheral clocks. Several small molecules generate daily circadian fluctuations ensuring inter-organ communication and coordination between external stimuli, i.e., light, food, and exercise, and body metabolism. As an orchestra, this complex network can be out of tone. Circadian disruption is often associated with obesity development and, above all, with diabetes and cardiovascular disease onset. Moreover, accumulating data highlight a bidirectional relationship between circadian misalignment and cardiometabolic disease severity. Food intake abnormalities, especially timing and composition of meal, are crucial cause of circadian disruption, but evidence from preclinical and clinical studies has shown that food could represent a unique therapeutic approach to promote circadian resynchronization. In this review, we briefly summarize the structure of circadian system and discuss the role playing by different molecules [from leptin to ghrelin, incretins, fibroblast growth factor 21 (FGF-21), growth differentiation factor 15 (GDF15)] to guarantee circadian homeostasis. Based on the recent data, we discuss the innovative nutritional interventions aimed at circadian re-synchronization and, consequently, improvement of cardiometabolic health.

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Variation within Variation: Comparison of 24-h Rhythm in Rodent Infarct Size between Ischemia Reperfusion and Permanent Ligation

Cited by 10 publications

References 26 publications

Anaesthesia-Induced Transcriptomic Changes in the Context of Renal Ischemia Uncovered by the Use of a Novel Clamping Device

Anaesthesia-Induced Transcriptomic Changes in the Context of Renal Ischemia Uncovered by the Use of a Novel Clamping Device

Circadian influence on the microbiome improves heart failure outcomes

Chrono-communication and cardiometabolic health: The intrinsic relationship and therapeutic nutritional promises

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